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维基百科

11β-甲氧基雌二醇

11β-甲氧基雌二醇(英語:11β-Methoxyestradiol,缩写11β-MeOE2,开发代号RU-2504)是一种人工合成雌激素甾体化合物,分子式C19H26O3,从未上市[1][2][3],结构上与莫克雌醇(11β-甲氧基-17α-乙炔基雌二醇)类似[3][2],其对雌激素受体的亲和力约为雌二醇的 86%[1][2]

11β-甲氧基雌二醇
臨床資料
其他名稱11β-MeOE2; 11βOMeEST; RU-2504; 11β-Methoxyestra-1,3,5(10)-triene-3,17β-diol
藥物類別英语Drug classEstrogen
识别信息
  • (8S,9S,11S,13S,14S,17S)-11-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CAS号21507-14-2  
PubChem CID
  • 68568
ChemSpider
  • 61838
UNII
  • R3M9HHJ34D
ChEMBL
  • ChEMBL368703
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
  • DTXSID80878441
化学信息
化学式C19H26O3
摩尔质量302.41 g·mol−1
3D模型(JSmol英语JSmol
  • 交互式图像
  • C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O)OC
  • InChI=1S/C19H26O3/c1-19-10-16(22-2)18-13-6-4-12(20)9-11(13)3-5-14(18)15(19)7-8-17(19)21/h4,6,9,14-18,20-21H,3,5,7-8,10H2,1-2H3/t14-,15-,16-,17-,18+,19-/m0/s1
  • Key:OAHDOJSNKCCHJM-VIUKOLAESA-N

参考资料 编辑

  1. ^ 1.0 1.1 Wolohan P, Reichert DE. CoMSIA and docking study of rhenium based estrogen receptor ligand analogs. Steroids. March 2007, 72 (3): 247–260. PMC 1964785 . PMID 17280694. doi:10.1016/j.steroids.2006.11.011. 
  2. ^ 2.0 2.1 2.2 Katzenellenbogen JA, Muthyala R. Interactions of exogenous endocrine active substances with nuclear receptors. Pure and Applied Chemistry. 2003, 75 (11–12): 1797–1817. ISSN 1365-3075. S2CID 86680540. doi:10.1351/pac200375111797. 
  3. ^ 3.0 3.1 Azadian-Boulanger G, Bertin D. Synthèse et activité utérotrophique des 11β-méthoxy estradiol 11β-méthoxy estriol et 11β-méthoxy 17α-éthynyl estradiol [Synthesis and uterotropic activity of 11β-methoxyestradiol, 11β-methoxyestriol, and 11β-methoxy-17α-ethynylestradiol]. Chimica Therapeutica. 1973, 8 (4): 451–454. ISSN 0009-4374. The prepn. and estrogenic activity of the 11β-methoxylated derivs. of estradiol, estriol, and 17α-ethynylestradiol were described. When administered orally to mice, the 3 compds. were from 10 to 1000 times more active than the corresponding nonmethoxylated estrogens. 

外部链接 编辑

11β, 甲氧基雌二醇, 英語, 11β, methoxyestradiol, 缩写11β, meoe2, 开发代号ru, 2504, 是一种人工合成的雌激素类甾体化合物, 分子式c19h26o3, 从未上市, 结构上与莫克雌醇, 11β, 甲氧基, 17α, 乙炔基雌二醇, 类似, 其对雌激素受体的亲和力约为雌二醇的, 臨床資料其他名稱11β, meoe2, 11βomeest, 2504, 11β, methoxyestra, triene, 17β, diol藥物類別, 英语, drug, class, es. 11b 甲氧基雌二醇 英語 11b Methoxyestradiol 缩写11b MeOE2 开发代号RU 2504 是一种人工合成的雌激素类甾体化合物 分子式C19H26O3 从未上市 1 2 3 结构上与莫克雌醇 11b 甲氧基 17a 乙炔基雌二醇 类似 3 2 其对雌激素受体的亲和力约为雌二醇的 86 1 2 11b 甲氧基雌二醇臨床資料其他名稱11b MeOE2 11bOMeEST RU 2504 11b Methoxyestra 1 3 5 10 triene 3 17b diol藥物類別 英语 Drug class Estrogen识别信息IUPAC命名法 8S 9S 11S 13S 14S 17S 11 methoxy 13 methyl 6 7 8 9 11 12 14 15 16 17 decahydrocyclopenta a phenanthrene 3 17 diolCAS号21507 14 2 PubChem CID68568ChemSpider61838UNIIR3M9HHJ34DChEMBLChEMBL368703CompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID80878441化学信息化学式C 19H 26O 3摩尔质量302 41 g mol 13D模型 JSmol 英语 JSmol 交互式图像SMILES C C 12C C H C H 3 C H C H 1CC C H 2O CCC4 C3C CC C4 O OCInChI InChI 1S C19H26O3 c1 19 10 16 22 2 18 13 6 4 12 20 9 11 13 3 5 14 18 15 19 7 8 17 19 21 h4 6 9 14 18 20 21H 3 5 7 8 10H2 1 2H3 t14 15 16 17 18 19 m0 s1Key OAHDOJSNKCCHJM VIUKOLAESA N参考资料 编辑 1 0 1 1 Wolohan P Reichert DE CoMSIA and docking study of rhenium based estrogen receptor ligand analogs Steroids March 2007 72 3 247 260 PMC 1964785 nbsp PMID 17280694 doi 10 1016 j steroids 2006 11 011 2 0 2 1 2 2 Katzenellenbogen JA Muthyala R Interactions of exogenous endocrine active substances with nuclear receptors Pure and Applied Chemistry 2003 75 11 12 1797 1817 ISSN 1365 3075 S2CID 86680540 doi 10 1351 pac200375111797 3 0 3 1 Azadian Boulanger G Bertin D Synthese et activite uterotrophique des 11b methoxy estradiol 11b methoxy estriol et 11b methoxy 17a ethynyl estradiol Synthesis and uterotropic activity of 11b methoxyestradiol 11b methoxyestriol and 11b methoxy 17a ethynylestradiol Chimica Therapeutica 1973 8 4 451 454 ISSN 0009 4374 The prepn and estrogenic activity of the 11b methoxylated derivs of estradiol estriol and 17a ethynylestradiol were described When administered orally to mice the 3 compds were from 10 to 1000 times more active than the corresponding nonmethoxylated estrogens 外部链接 编辑 取自 https zh wikipedia org w index php title 11b 甲氧基雌二醇 amp oldid 78006761, 维基百科,wiki,书籍,书籍,图书馆,

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