敌百虫

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敌百虫（英語：trichlorfon，也称为美曲磷酯，Metrifonate）是一种有机磷酸酯杀虫剂和乙酰胆碱酯酶抑制剂（英语：acetylcholinesterase inhibitor）^[3]，是一种前体药物，可在非酶促情况下转化为敌敌畏， 可用于治疗血吸虫病^[4]，但没有商业化应用^[5]，也有提议用于治疗阿茲海默症，但并未通过^[6]。

敌百虫

臨床資料
商品名（英语：Drug nomenclature）	Chlorophos (and many others)^[1]Trichlorfon; Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl) dimethylphosphonate; Agroforotox; Anthon; Chlorofos; Chloroftalm; Chlorophos; Chlorophthalm; Chloroxyphos; Combot; Dimethyl (trichlorohydroxyethyl)phosphonate; Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; Dipterax; Dipterex; Dipterex 50; Diptevur; Ditrifon; Dylox; Dyrex; Dyvon; DEP; DEP (Pesticide); DETF; ENT 19,763; Flibol E; Fliegenteller; Forotox; Foschlor; Foschlor R; Foschlor R 50; Hypodermacid; Loisol; Masoten; Mazoten; Methyl Chlorophos; Metifonate; Metriphonate; Neguron; Neguvon; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; O,O-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; O,O-Dimethyl (2,2,2-trichlorohydroxyethyl)phosphonate; Phoschlor; Phoschlor R50; Polfoschlor; Ricifon; Ritsifon; Soldep; Sotipox; Trichlorphon; Trichlorphon FN; Tugon; Volfartol; Votexit; Wotexit; WEC 50; (1-Hydroxy-2,2,2-trichloroethyl)phosphonic acid, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl)phosphonate, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl)phosphonic acid dimethyl ester; Bayer L 1359; Bilarcil; Bovinox; Briton; BAY 15922; Cekufon; Chlorophosciclosom; Clorofos; Danex; Dimethoxy-(2,2,2-trichloro-1-hydroxyethyl)phosphine oxide; Equino-Aid; Foschlorem; Khloroftalm; NCI-C54831; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphate; O,O-Dimethyl-(1-hydroxy-2,2,2-trichloraethyl)phosphosaeure ester; O,O-Dimethyl-(1-hydroxy-2,2,2-trichlorathyl)-phosphat; O,O-Dimethyl-(2,2,2-trichloor-1-hydroxy-ethyl)-fosfonaat; O,O-Dimethyl-(2,2,2-trichlor-1-hydroxy-aethyl)phosphonat; O,O-Dimetil-(2,2,2-tricloro-1-idrossi-etil)-fosfonato; Phosphonic acid, (1-hydroxy-2,2,2-trichloroethyl)-, dimethyl ester; Proxol; Trichloorfon; Trichlorofon; Trichlorophon; Trinex; 1-Hydroxy-2,2,2-trichloro-ethyle phosphonate de dimethyle; Bay-L 1359; Briten; Denkaphon; Dipterex WP 80; Ertefon; OMS 800; Zeltivar; Onefon; O,O-Dimethyl-1-oxy-2,2,2-trichloroethyl phosphonate;Trichlorfon; 1-Hydroxy-2,2,2-trichloroethylphosphonate-O,O-dimethyl ester; Phosphonic acid, P-(2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; Chlorak; Dimetox; Dioxaphos^[2]
其他名稱	Trichlorphon
AHFS（英语：American Society of Health-System Pharmacists）/Drugs.com	国际药品名称
ATC碼	P02BB01 (WHO) QP52（英语：ATCvet code QP52）AB01 QP53（英语：ATCvet code QP53）AF02
藥物動力學數據
生物半衰期	3 hours
识别信息
IUPAC命名法 (RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
CAS号	52-68-6
PubChem CID	5853
ChemSpider	5644^N
UNII	DBF2DG4G2K
KEGG	C07971
ChEBI	CHEBI:6908^N
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID0021389
ECHA InfoCard	100.000.137
化学信息
化学式	C4H8Cl3O4P
摩尔质量	257.436 g/mol
3D模型（JSmol（英语：JSmol））	交互式图像
手性	Racemic mixture
SMILES COP(=O)(C(C(Cl)(Cl)Cl)O)OC
InChI InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3^N Key:NFACJZMKEDPNKN-UHFFFAOYSA-N^N

参考文献

1. . Haz-Map. U.S. National Library of Medicine. August 2015 [2015-10-13]. （原始内容存档于2015-09-20）. 
2. Metrifonate. U.S. National Institute of Standards and Technology. [2016-09-04]. （原始内容于2020-04-03）. 
3. . （原始内容存档于2009-07-19）. 
4. Monographs: Pharmaceutical substances: Metrifonate (Metrifonatum). The International Pharmacopoeia Fourth Edition. WHO. [2015-10-20]. （原始内容于2016-06-03）.  (dead link 31 January 2019)
5. Ross AG, Bartley PB, Sleigh AC, Olds GR, Li Y, Williams GM, McManus DP. Schistosomiasis. The New England Journal of Medicine. April 2002, 346 (16): 1212–20. PMID 11961151. doi:10.1056/NEJMra012396. 
6. López-Arrieta JM, Schneider L. López-Arrieta J , 编. Metrifonate for Alzheimer's disease. The Cochrane Database of Systematic Reviews. April 2006, (2): CD003155. PMID 16625573. doi:10.1002/14651858.CD003155.pub3.