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维基百科

芦平曲韦

四月 02, 2023

维基百科中的醫學内容仅供参考，並不能視作專業意見。如需獲取醫療幫助或意見，请咨询专业人士。詳見醫學聲明。

芦平曲韦（英語：Rupintrivir，也叫AG-7088、Rupinavir）是一种拟肽抗病毒药物，可作为小核糖核酸病毒3C蛋白酶和3C样蛋白酶抑制剂。[1][2][3]它是为治疗鼻病毒而开发的，[4][5]随后被研究用于治疗其他病毒性疾病，包括由小核糖核酸病毒引起的疾病、[6][7]诺如病毒、[8]和冠状病毒，例如SARS和COVID-19。[9][10]

芦平曲韦
臨床資料
商品名（英语：Drug nomenclature）Rupintrivir
法律規範狀態
法律規範
  • 美: Investigational drug
识别信息
CAS号223537-30-2
PubChem CID
  • 6440352
DrugBank
  • 05102
ChemSpider
  • 4944627
UNII
  • RGE5K1Q5QW
KEGG
  • D05776
ChEMBL
  • ChEMBL20210
化学信息
化学式C31H39FN4O7
摩尔质量598.7
3D模型（JSmol（英语：JSmol））
  • 交互式图像

参见

参考文献

  1. ^ Dragovich PS, Prins TJ, Zhou R, Webber SE, Marakovits JT, Fuhrman SA, et al. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. Journal of Medicinal Chemistry. April 1999, 42 (7): 1213–24. PMID 10197965. doi:10.1021/jm9805384. 
  2. ^ Santos MM, Moreira R. Michael acceptors as cysteine protease inhibitors. Mini Reviews in Medicinal Chemistry. October 2007, 7 (10): 1040–50. PMID 17979807. doi:10.2174/138955707782110105. 
  3. ^ Yuan S, Fan K, Chen Z, Sun Y, Hou H, Zhu L. Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design. Virologica Sinica. February 2020, 35 (4): 445–454. PMC 7462945  . PMID 32103448. doi:10.1007/s12250-020-00196-4. 
  4. ^ Patick AK, Binford SL, Brothers MA, Jackson RL, Ford CE, Diem MD, et al. In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrobial Agents and Chemotherapy. October 1999, 43 (10): 2444–50. PMC 89498  . PMID 10508022. doi:10.1128/AAC.43.10.2444. 
  5. ^ Jensen LM, Walker EJ, Jans DA, Ghildyal R. Proteases of human rhinovirus: role in infection. Rhinoviruses. Methods in Molecular Biology 1221. 2015: 129–41. ISBN 978-1-4939-1570-5. PMID 25261311. doi:10.1007/978-1-4939-1571-2_10. 
  6. ^ Barnard DL. Current status of anti-picornavirus therapies. Current Pharmaceutical Design. 2006, 12 (11): 1379–90. PMID 16611122. doi:10.2174/138161206776361129. 
  7. ^ De Palma AM, Vliegen I, De Clercq E, Neyts J. Selective inhibitors of picornavirus replication. Medicinal Research Reviews. November 2008, 28 (6): 823–84. PMID 18381747. S2CID 1575335. doi:10.1002/med.20125. 
  8. ^ Rocha-Pereira J, Nascimento MS, Ma Q, Hilgenfeld R, Neyts J, Jochmans D. The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon. Antimicrobial Agents and Chemotherapy. August 2014, 58 (8): 4675–81. PMC 4136040  . PMID 24890597. doi:10.1128/AAC.02546-13. 
  9. ^ Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science. June 2003, 300 (5626): 1763–7. Bibcode:2003Sci...300.1763A. PMID 12746549. doi:10.1126/science.1085658  . 
  10. ^ Liu C, Zhou Q, Li Y, Garner LV, Watkins SP, Carter LJ, et al. Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases. ACS Central Science. 2020, 6 (3): 315–331. PMC 7094090  . PMID 32226821. doi:10.1021/acscentsci.0c00272  . 

四月 02, 2023
芦平曲韦, 维基百科中的醫學内容仅供参考, 並不能視作專業意見, 如需獲取醫療幫助或意見, 请咨询专业人士, 詳見醫學聲明, 英語, rupintrivir, 也叫ag, 7088, rupinavir, 是一种拟肽抗病毒药物, 可作为小核糖核酸病毒3c蛋白酶和3c样蛋白酶抑制剂, 它是为治疗鼻病毒而开发的, 随后被研究用于治疗其他病毒性疾病, 包括由小核糖核酸病毒引起的疾病, 诺如病毒, 和冠状病毒, 例如sars和covid, 臨床資料商品名, 英语, drug, nomenclature, rupintriv. 维基百科中的醫學内容仅供参考 並不能視作專業意見 如需獲取醫療幫助或意見 请咨询专业人士 詳見醫學聲明 芦平曲韦 英語 Rupintrivir 也叫AG 7088 Rupinavir 是一种拟肽抗病毒药物 可作为小核糖核酸病毒3C蛋白酶和3C样蛋白酶抑制剂 1 2 3 它是为治疗鼻病毒而开发的 4 5 随后被研究用于治疗其他病毒性疾病 包括由小核糖核酸病毒引起的疾病 6 7 诺如病毒 8 和冠状病毒 例如SARS和COVID 19 9 10 芦平曲韦臨床資料商品名 英语 Drug nomenclature Rupintrivir法律規範狀態法律規範美 Investigational drug识别信息IUPAC命名法 ethyl E 4S 4 2R 5S 2 4 fluorophenyl methyl 6 methyl 5 5 methyl 1 2 oxazole 3 carbonyl amino 4 oxoheptanoyl amino 5 3S 2 oxopyrrolidin 3 yl pent 2 enoateCAS号223537 30 2PubChem CID6440352DrugBank05102ChemSpider4944627UNIIRGE5K1Q5QWKEGGD05776ChEMBLChEMBL20210化学信息化学式C 31H 39F N 4O 7摩尔质量598 73D模型 JSmol 英语 JSmol 交互式图像SMILES CCOC O C C C H C C H 1CCNC1 O NC O C H CC2 CC C C C2 F CC O C H C C C NC O C3 NOC C3 CInChI InChI 1S C31H39FN4O7 c1 5 42 27 38 11 10 24 16 21 12 13 33 29 21 39 34 30 40 22 15 20 6 8 23 32 9 7 20 17 26 37 28 18 2 3 35 31 41 25 14 19 4 43 36 25 h6 11 14 18 21 22 24 28H 5 12 13 15 17H2 1 4H3 H 33 39 H 34 40 H 35 41 b11 10 t21 22 24 28 m0 s1Key CAYJBRBGZBCZKO BHGBQCOSSA N参见 编辑3CLpro 1 卡莫氟 依布硒 GC376 茶黄素双没食子酸酯参考文献 编辑 Dragovich PS Prins TJ Zhou R Webber SE Marakovits JT Fuhrman SA et al Structure based design synthesis and biological evaluation of irreversible human rhinovirus 3C protease inhibitors 4 Incorporation of P1 lactam moieties as L glutamine replacements Journal of Medicinal Chemistry April 1999 42 7 1213 24 PMID 10197965 doi 10 1021 jm9805384 Santos MM Moreira R Michael acceptors as cysteine protease inhibitors Mini Reviews in Medicinal Chemistry October 2007 7 10 1040 50 PMID 17979807 doi 10 2174 138955707782110105 Yuan S Fan K Chen Z Sun Y Hou H Zhu L Structure of the HRV C 3C Rupintrivir Complex Provides New Insights for Inhibitor Design Virologica Sinica February 2020 35 4 445 454 PMC 7462945 PMID 32103448 doi 10 1007 s12250 020 00196 4 Patick AK Binford SL Brothers MA Jackson RL Ford CE Diem MD et al In vitro antiviral activity of AG7088 a potent inhibitor of human rhinovirus 3C protease Antimicrobial Agents and Chemotherapy October 1999 43 10 2444 50 PMC 89498 PMID 10508022 doi 10 1128 AAC 43 10 2444 Jensen LM Walker EJ Jans DA Ghildyal R Proteases of human rhinovirus role in infection Rhinoviruses Methods in Molecular Biology 1221 2015 129 41 ISBN 978 1 4939 1570 5 PMID 25261311 doi 10 1007 978 1 4939 1571 2 10 Barnard DL Current status of anti picornavirus therapies Current Pharmaceutical Design 2006 12 11 1379 90 PMID 16611122 doi 10 2174 138161206776361129 De Palma AM Vliegen I De Clercq E Neyts J Selective inhibitors of picornavirus replication Medicinal Research Reviews November 2008 28 6 823 84 PMID 18381747 S2CID 1575335 doi 10 1002 med 20125 Rocha Pereira J Nascimento MS Ma Q Hilgenfeld R Neyts J Jochmans D The enterovirus protease inhibitor rupintrivir exerts cross genotypic anti norovirus activity and clears cells from the norovirus replicon Antimicrobial Agents and Chemotherapy August 2014 58 8 4675 81 PMC 4136040 PMID 24890597 doi 10 1128 AAC 02546 13 Anand K Ziebuhr J Wadhwani P Mesters JR Hilgenfeld R Coronavirus main proteinase 3CLpro structure basis for design of anti SARS drugs Science June 2003 300 5626 1763 7 Bibcode 2003Sci 300 1763A PMID 12746549 doi 10 1126 science 1085658 Liu C Zhou Q Li Y Garner LV Watkins SP Carter LJ et al Research and Development on Therapeutic Agents and Vaccines for COVID 19 and Related Human Coronavirus Diseases ACS Central Science 2020 6 3 315 331 PMC 7094090 PMID 32226821 doi 10 1021 acscentsci 0c00272 取自 https zh wikipedia org w index php title 芦平曲韦 amp oldid 75103641, 维基百科，wiki，书籍，书籍，图书馆，

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