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维基百科

組蛋白修飾酶

八月 18, 2023

組蛋白修飾酶（Histone-modifying enzymes）泛指真核生物細胞中修飾包裹DNA的組蛋白之酵素。組蛋白上的許多位點可被酵素修飾[1]，共同組成組蛋白密碼[2]。已知的修飾種類包括乙醯化[3]、甲基化[4]、磷酸化[5]、泛素化[6]、GlcNAc糖基化（英语：GlcNAc）[7]、二磷酸腺苷核糖基化[8]、瓜氨酸化[9]、脯胺酸異構化（英语：Proline isomerization in epigenetics）[10]與SUMO修飾（英语：SUMO protein）等[11]，這些修飾可能改變染色體結構或與其他蛋白結合的能力，進而促進或抑制基因的轉錄[2]。

組蛋白修飾酶種類與位點一覽

參見

參考文獻

  1. ^ Kouzarides T. Chromatin modifications and their function. Cell. February 2007, 128 (4): 693–705. PMID 17320507. doi:10.1016/j.cell.2007.02.005. 
  2. ^ 2.0 2.1 Jenuwein T, Allis C. Translating the histone code. Science. 2001, 293 (5532): 1074–80. PMID 11498575. doi:10.1126/science.1063127. 
  3. ^ Sterner DE, Berger SL. Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. June 2000, 64 (2): 435–59. PMC 98999  . PMID 10839822. doi:10.1128/MMBR.64.2.435-459.2000. 
  4. ^ Zhang Y, Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev. 2001, 15 (18): 2343–60. PMID 11562345. doi:10.1101/gad.927301. 
  5. ^ Nowak SJ, Corces VG. Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet. April 2004, 20 (4): 214–20. PMID 15041176. doi:10.1016/j.tig.2004.02.007. 
  6. ^ Shilatifard A. Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu. Rev. Biochem. 2006, 75: 243–69. PMID 16756492. doi:10.1146/annurev.biochem.75.103004.142422. 
  7. ^ K, Sakabe; Z, Wang; Gw, Hart. Beta-N-acetylglucosamine (O-GlcNAc) Is Part of the Histone Code. Proceedings of the National Academy of Sciences of the United States of America. 2010-11-16, 107 (46): 19915–20. Bibcode:2010PNAS..10719915S. PMC 2993388  . PMID 21045127. doi:10.1073/pnas.1009023107. 
  8. ^ Hassa PO, Haenni SS, Elser M, Hottiger MO. Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?. Microbiol. Mol. Biol. Rev. September 2006, 70 (3): 789–829. PMC 1594587  . PMID 16959969. doi:10.1128/MMBR.00040-05. 
  9. ^ Cuthbert GL, Daujat S, Snowden AW, et al. Histone deimination antagonizes arginine methylation. Cell. September 2004, 118 (5): 545–53. PMID 15339660. doi:10.1016/j.cell.2004.08.020. 
  10. ^ Nelson CJ, Santos-Rosa H, Kouzarides T. Proline isomerization of histone H3 regulates lysine methylation and gene expression. Cell. September 2006, 126 (5): 905–16. PMID 16959570. doi:10.1016/j.cell.2006.07.026. 
  11. ^ Nathan D, Ingvarsdottir K, Sterner DE, et al. Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev. April 2006, 20 (8): 966–76. PMC 1472304  . PMID 16598039. doi:10.1101/gad.1404206. 

八月 18, 2023
組蛋白修飾酶, histone, modifying, enzymes, 泛指真核生物細胞中修飾包裹dna的組蛋白之酵素, 組蛋白上的許多位點可被酵素修飾, 共同組成組蛋白密碼, 已知的修飾種類包括乙醯化, 甲基化, 磷酸化, 泛素化, glcnac糖基化, 英语, glcnac, 二磷酸腺苷核糖基化, 瓜氨酸化, 脯胺酸異構化, 英语, proline, isomerization, epigenetics, 與sumo修飾, 英语, sumo, protein, 這些修飾可能改變染色體結構或與其他蛋白結合的能力. 組蛋白修飾酶 Histone modifying enzymes 泛指真核生物細胞中修飾包裹DNA的組蛋白之酵素 組蛋白上的許多位點可被酵素修飾 1 共同組成組蛋白密碼 2 已知的修飾種類包括乙醯化 3 甲基化 4 磷酸化 5 泛素化 6 GlcNAc糖基化 英语 GlcNAc 7 二磷酸腺苷核糖基化 8 瓜氨酸化 9 脯胺酸異構化 英语 Proline isomerization in epigenetics 10 與SUMO修飾 英语 SUMO protein 等 11 這些修飾可能改變染色體結構或與其他蛋白結合的能力 進而促進或抑制基因的轉錄 2 組蛋白修飾酶種類與位點一覽參見 编辑組蛋白乙醯轉移酶 HAT 組蛋白脫乙醯酶 HDAC 组蛋白甲基转移酶 HMT 參考文獻 编辑 分子与细胞生物学主题 Kouzarides T Chromatin modifications and their function Cell February 2007 128 4 693 705 PMID 17320507 doi 10 1016 j cell 2007 02 005 2 0 2 1 Jenuwein T Allis C Translating the histone code Science 2001 293 5532 1074 80 PMID 11498575 doi 10 1126 science 1063127 Sterner DE Berger SL Acetylation of histones and transcription related factors Microbiol Mol Biol Rev June 2000 64 2 435 59 PMC 98999 PMID 10839822 doi 10 1128 MMBR 64 2 435 459 2000 Zhang Y Reinberg D Transcription regulation by histone methylation interplay between different covalent modifications of the core histone tails Genes Dev 2001 15 18 2343 60 PMID 11562345 doi 10 1101 gad 927301 Nowak SJ Corces VG Phosphorylation of histone H3 a balancing act between chromosome condensation and transcriptional activation Trends Genet April 2004 20 4 214 20 PMID 15041176 doi 10 1016 j tig 2004 02 007 Shilatifard A Chromatin modifications by methylation and ubiquitination implications in the regulation of gene expression Annu Rev Biochem 2006 75 243 69 PMID 16756492 doi 10 1146 annurev biochem 75 103004 142422 K Sakabe Z Wang Gw Hart Beta N acetylglucosamine O GlcNAc Is Part of the Histone Code Proceedings of the National Academy of Sciences of the United States of America 2010 11 16 107 46 19915 20 Bibcode 2010PNAS 10719915S PMC 2993388 PMID 21045127 doi 10 1073 pnas 1009023107 Hassa PO Haenni SS Elser M Hottiger MO Nuclear ADP ribosylation reactions in mammalian cells where are we today and where are we going Microbiol Mol Biol Rev September 2006 70 3 789 829 PMC 1594587 PMID 16959969 doi 10 1128 MMBR 00040 05 Cuthbert GL Daujat S Snowden AW et al Histone deimination antagonizes arginine methylation Cell September 2004 118 5 545 53 PMID 15339660 doi 10 1016 j cell 2004 08 020 Nelson CJ Santos Rosa H Kouzarides T Proline isomerization of histone H3 regulates lysine methylation and gene expression Cell September 2006 126 5 905 16 PMID 16959570 doi 10 1016 j cell 2006 07 026 Nathan D Ingvarsdottir K Sterner DE et al Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive acting histone modifications Genes Dev April 2006 20 8 966 76 PMC 1472304 PMID 16598039 doi 10 1101 gad 1404206 取自 https zh wikipedia org w index php title 組蛋白修飾酶 amp oldid 71676996, 维基百科，wiki，书籍，书籍，图书馆，

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