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维基百科

白花丹素

白花丹素Plumbagin5-hydroxy-2-methyl-1,4-naphthoquinone)为萘醌衍生物,为黄色染料。[1]其得名于植物白花丹Plumbago[2]白花丹素常见于茅膏菜猪笼草体内。[3]

白花丹素
IUPAC名
5-hydroxy-2-methyl-naphthalene-1,4-dione
识别
CAS号 481-42-5  
PubChem 10205
ChemSpider 9790
SMILES
InChI
InChIKey VCMMXZQDRFWYSE-UHFFFAOYAB
ChEBI 8273
KEGG C10387
性质
化学式 C11H8O3
摩尔质量 188.17942 g/mol g·mol⁻¹
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

药理性质

各种细胞和动物模型试验中得出了以下药理学特性:

参考文献

  1. ^ Black Walnut (页面存档备份,存于互联网档案馆). Drugs.com.
  2. ^ Van der Vijver, L.M. 1972. Distribution of plumbagin in the Plumbaginaceae. Phytochemistry 11: 3247–3248.
  3. ^ Wang, W., X. Luo, & H. Li 2010. Terahertz and infrared spectra of plumbagin, juglone, and menadione. Carnivorous Plant Newsletter 39(3): 82–88.
  4. ^ Didry, N., L. Dubrevil & M. Pinkas 1994. Activity of anthraquinonic and naphthoquinonic compounds on oral bacteria. Die Pharmazie 49(9): 681–683.
  5. ^ Paiva, S.R.d., M.R. Figueiredo, T. V. Aragão, M.A.C. Kaplan 2003. Antimicrobial Activity in Vitro of Plumbagin Isolated from Plumbago Species.PDF (511 KiB) Mem Inst Oswaldo Cruz 98(7): 959–961.
  6. ^ Likhitwitayawuid, K., R. Kaewamatawong, N. Ruangrungsi & J. Krungkrai 1998. Antimalarial naphthoquinones from Nepenthes thorelii. Planta Medica 64(3): 237–241.
  7. ^ Checker R., Sharma D., Sandur S.K., Subrahmanyam G., Krishnan S., Poduval T.B., Sainis K.B. "Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols" Journal of Cellular Biochemistry 2010 110:5 (1082-1093)
  8. ^ Parimala, R. & P. Sachdanandam 1993. Effect of plumbagin on some glucose metabolizing enzymes studied in rats in experimental hepatoma. Molecular and Cellular Biochemistry 12(1): 59–63.
  9. ^ Hsu, Y.-L., C.-Y. Cho, P.-L. Kuo, Y.-T. Huang & C.-C. Lin 2006. Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH2-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo. Journal of Pharmacology and Experimental Therapeutics 318(2): 484–494. doi:10.1124/jpet.105.098863 PMID 16632641
  10. ^ Itoigawa, M., K. Takeya & H. Furukawa 1991. Cardiotonic action of plumbagin on guinea-pig papillary muscle. Planta Medica 57(4): 317–319.
  11. ^ McKallip, Robert J. Lombard, Catherine. Sun, Jingping. Ramakrishnan, Rupal. "Plumbagin-induced apoptosis in lymphocytes is mediated through increased reactive oxygen species production, upregulation of Fas, and activation of the caspase cascade."Toxicology & Applied Pharmacology. 247(1):41-52, 2010 Aug 15.
  12. ^ Bhargava, S.K. 1984. Effects of plumbagin on reproductive function of male dog. Indian Journal of Experimental Biology 22(3): 153–156.
  13. ^ Son TG. Camandola S. Arumugam TV. Cutler RG. Telljohann RS. Mughal MR. Moore TA. Luo W. Yu QS. Johnson DA. Johnson JA. Greig NH. Mattson MP. Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia.
  14. ^ Ding, Y., Z.-J. Chen, S. Liu, D. Che, M. Vetter, C.-H. Chang 2005. Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone. Journal of Pharmacy and Pharmacology 57(1): 111.

白花丹素, plumbagin, hydroxy, methyl, naphthoquinone, 为萘醌衍生物, 为黄色染料, 其得名于植物白花丹, plumbago, 常见于茅膏菜和猪笼草体内, iupac名5, hydroxy, methyl, naphthalene, dione识别cas号, pubchem, 10205chemspider, 9790smiles, 2c1c, cccc1c, cinchi, c11h8o3, 1h3inchikey, vcmmxzqdrfwyse, uhfffaoyab. 白花丹素 Plumbagin 5 hydroxy 2 methyl 1 4 naphthoquinone 为萘醌衍生物 为黄色染料 1 其得名于植物白花丹 Plumbago 2 白花丹素常见于茅膏菜和猪笼草体内 3 白花丹素IUPAC名5 hydroxy 2 methyl naphthalene 1 4 dione识别CAS号 481 42 5 PubChem 10205ChemSpider 9790SMILES O C 2c1c O cccc1C O C C 2 CInChI 1 C11H8O3 c1 6 5 9 13 10 7 11 6 14 3 2 4 8 10 12 h2 5 12H 1H3InChIKey VCMMXZQDRFWYSE UHFFFAOYABChEBI 8273KEGG C10387性质化学式 C11H8O3摩尔质量 188 17942 g mol g mol 若非注明 所有数据均出自标准状态 25 100 kPa 下 药理性质 编辑各种细胞和动物模型试验中得出了以下药理学特性 抗菌 4 5 抗疟疾 6 抗炎 7 抗癌 8 9 强心 10 免疫抑制 11 抗生育 12 神经保护 13 抗动脉粥样硬化 14 参考文献 编辑 Black Walnut 页面存档备份 存于互联网档案馆 Drugs com Van der Vijver L M 1972 Distribution of plumbagin in the Plumbaginaceae Phytochemistry 11 3247 3248 Wang W X Luo amp H Li 2010 Terahertz and infrared spectra of plumbagin juglone and menadione Carnivorous Plant Newsletter 39 3 82 88 Didry N L Dubrevil amp M Pinkas 1994 Activity of anthraquinonic and naphthoquinonic compounds on oral bacteria Die Pharmazie 49 9 681 683 Paiva S R d M R Figueiredo T V Aragao M A C Kaplan 2003 Antimicrobial Activity in Vitro of Plumbagin Isolated from Plumbago Species PDF 511 KiB Mem Inst Oswaldo Cruz 98 7 959 961 Likhitwitayawuid K R Kaewamatawong N Ruangrungsi amp J Krungkrai 1998 Antimalarial naphthoquinones from Nepenthes thorelii Planta Medica 64 3 237 241 Checker R Sharma D Sandur S K Subrahmanyam G Krishnan S Poduval T B Sainis K B Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols Journal of Cellular Biochemistry 2010 110 5 1082 1093 Parimala R amp P Sachdanandam 1993 Effect of plumbagin on some glucose metabolizing enzymes studied in rats in experimental hepatoma Molecular and Cellular Biochemistry 12 1 59 63 Hsu Y L C Y Cho P L Kuo Y T Huang amp C C Lin 2006 Plumbagin 5 Hydroxy 2 methyl 1 4 naphthoquinone Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c Jun NH2 Terminal Kinase Mediated Phosphorylation at Serine 15 in Vitro and in Vivo Journal of Pharmacology and Experimental Therapeutics 318 2 484 494 doi 10 1124 jpet 105 098863 PMID 16632641 Itoigawa M K Takeya amp H Furukawa 1991 Cardiotonic action of plumbagin on guinea pig papillary muscle Planta Medica 57 4 317 319 McKallip Robert J Lombard Catherine Sun Jingping Ramakrishnan Rupal Plumbagin induced apoptosis in lymphocytes is mediated through increased reactive oxygen species production upregulation of Fas and activation of the caspase cascade Toxicology amp Applied Pharmacology 247 1 41 52 2010 Aug 15 Bhargava S K 1984 Effects of plumbagin on reproductive function of male dog Indian Journal of Experimental Biology 22 3 153 156 Son TG Camandola S Arumugam TV Cutler RG Telljohann RS Mughal MR Moore TA Luo W Yu QS Johnson DA Johnson JA Greig NH Mattson MP Plumbagin a novel Nrf2 ARE activator protects against cerebral ischemia Ding Y Z J Chen S Liu D Che M Vetter C H Chang 2005 Inhibition of Nox 4 activity by plumbagin a plant derived bioactive naphthoquinone Journal of Pharmacy and Pharmacology 57 1 111 取自 https zh wikipedia org w index php title 白花丹素 amp oldid 69731075, 维基百科,wiki,书籍,书籍,图书馆,

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