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维基百科

猪笼草蛋白酶

行進 26, 2023

猪笼草蛋白酶（Nepenthesin，Nepenthacin[1][2]，Nepenthasin[3]），又称猪笼草酸性蛋白酶，猪笼草天冬氨酸蛋白酶[3]是猪笼草捕虫笼及盾叶茅膏菜（Drosera peltata）分泌的天冬氨酸蛋白酶。[4][5][6][7][8][9]其与胃蛋白酶类似，但其也能酶切两侧的天冬氨酸残基及赖氨酸┼精氨酸。[3]其对pH值及温度的稳定性高于猪胃蛋白酶A，对尿素及盐酸胍的稳定性大大降低。[10]

猪笼草蛋白酶
识别码
EC編號 3.4.23.12
CAS号 9073-80-7
数据库
IntEnz IntEnz浏览
BRENDA（英语：BRENDA） BRENDA入口
ExPASy（英语：ExPASy） NiceZyme浏览
KEGG KEGG入口
MetaCyc（英语：MetaCyc） 代谢路径
PRIAM（英语：PRIAM_enzyme-specific_profiles） 概述
PDB RCSB PDB PDBj PDBe PDBsum

1968年，Shigeru Nakayama和Shizuko Amagase以“nepenthesin”命名猪笼草蛋白酶。[11]在猪笼草属中已确定了2个同工酶：猪笼草蛋白酶I与猪笼草蛋白酶II。[12]

参考文献

  1. ^ Jentsch J. Enzymes from carnivorous plants (nepenthes). Isolation of the protease nepenthacin. FEBS Lett. April 1972, 21 (3): 273–276. PMID 11946525. doi:10.1016/0014-5793(72)80181-9. 
  2. ^ Jentsch J, Meierkord S, Hammer M. The enzymes from carnivorous plants (Nepenthes): Properties and characterization of the acid protease nepenthacin. Planta Medica. 1989, 55: 227. doi:10.1055/s-2006-961979. 
  3. ^ 3.0 3.1 3.2 EC 3.4.23.12 - Nepenthesin （页面存档备份，存于互联网档案馆）. Integrated Enzyme Database (IntEnz).
  4. ^ Amagase S, Nakayama S, Tsugita A. Acid protease in Nepenthes. II. Study on the specificity of nepenthesin. J. Biochem. October 1969, 66 (4): 431–9. PMID 5354017. 
  5. ^ Amagase S. Digestive enzymes in insectivorous plants. 3. Acid proteases in the genus Nepenthes and Drosera peltata. J. Biochem. July 1972, 72 (1): 73–81. PMID 5069751. 
  6. ^ Amagase S, Mori M, Nakayama S. Digestive enzymes in insectivorous plants. IV. Enzymatic digestion of insects by Nepenthes secretion and Drosera peltata extract: proteolytic and chitinolytic activities. J. Biochem. September 1972, 72 (3): 765–7. PMID 4634982. 
  7. ^ Tökés ZA, Woon WC, Chambers SM. Digestive enzymes secreted by the carnivorous plant Nepenthes macferlanei L. Planta. March 1974, 119 (1): 39–46. doi:10.1007/BF00390820. 
  8. ^ Athauda SBP, Inoue H, Iwamatsu A, Takahashi K. Acid Proteinase from Nepenthes distillatoria (Badura). James, Michael (编). Aspartic proteinases: retroviral and cellular enzymes. New York: Plenum. 1998: 453–458. ISBN 0-306-45809-8. 
  9. ^ Takahashi K, Tanji M, Shibata C. Variations in the content and isozymic composition of nepenthesin in the pitcher fluids among Nepenthes species (PDF). Carnivorous Plant News Letter. 2007, 36 (3): 73–76 [2011-12-10]. （原始内容 (PDF)于2012-02-27）. 
  10. ^ Kubota K, Metoki Y, Athauda SBP, Shibata C, Takahashi K. Stability Profiles of Nepenthesin in Urea and Guanidine Hydrochloride: Comparison with Porcine Pepsin A. Bioscience, Biotechnology, and Biochemistry. 2010, 74 (11): 2323–2326. doi:10.1271/bbb.100391. 
  11. ^ Nakayama S, Amagase S. Acid Protease in Nepenthes: Partial Purification and Properties of the Enzyme. Proceedings of the Japan Academy. 1968, 44 (5): 358–362. [永久失效連結]
  12. ^ Athauda SB, Matsumoto K, Rajapakshe S, Kuribayashi M, Kojima M, Kubomura-Yoshida N, Iwamatsu A, Shibata C, Inoue H, Takahashi K. Enzymic and structural characterization of nepenthesin, a unique member of a novel subfamily of aspartic proteinases. Biochem. J. July 2004, 381 (Pt 1): 295–306. PMC 1133788  . PMID 15035659. doi:10.1042/BJ20031575. 

扩展阅读

  • The MEROPS online database for peptidases and their inhibitors: A01.040

行進 26, 2023
猪笼草蛋白酶, nepenthesin, nepenthacin, nepenthasin, 又称猪笼草酸性蛋白酶, 猪笼草天冬氨酸蛋白酶, 是猪笼草捕虫笼及盾叶茅膏菜, drosera, peltata, 分泌的天冬氨酸蛋白酶, 其与胃蛋白酶类似, 但其也能酶切两侧的天冬氨酸残基及赖氨酸, 精氨酸, 其对ph值及温度的稳定性高于猪胃蛋白酶a, 对尿素及盐酸胍的稳定性大大降低, 命名系统命名缩写识别码ec編號, 12cas号, 9073, 7数据库intenz, intenz浏览brenda, 英语, brenda. 猪笼草蛋白酶 Nepenthesin Nepenthacin 1 2 Nepenthasin 3 又称猪笼草酸性蛋白酶 猪笼草天冬氨酸蛋白酶 3 是猪笼草捕虫笼及盾叶茅膏菜 Drosera peltata 分泌的天冬氨酸蛋白酶 4 5 6 7 8 9 其与胃蛋白酶类似 但其也能酶切两侧的天冬氨酸残基及赖氨酸 精氨酸 3 其对pH值及温度的稳定性高于猪胃蛋白酶A 对尿素及盐酸胍的稳定性大大降低 10 猪笼草蛋白酶命名系统命名缩写识别码EC編號 3 4 23 12CAS号 9073 80 7数据库IntEnz IntEnz浏览BRENDA 英语 BRENDA BRENDA入口ExPASy 英语 ExPASy NiceZyme浏览KEGG KEGG入口MetaCyc 英语 MetaCyc 代谢路径PRIAM 英语 PRIAM enzyme specific profiles 概述PDB RCSB PDB PDBj PDBe PDBsum搜索PMC 相关文献PubMed 相关文献1968年 Shigeru Nakayama和Shizuko Amagase以 nepenthesin 命名猪笼草蛋白酶 11 在猪笼草属中已确定了2个同工酶 猪笼草蛋白酶I与猪笼草蛋白酶II 12 参考文献 编辑 Jentsch J Enzymes from carnivorous plants nepenthes Isolation of the protease nepenthacin FEBS Lett April 1972 21 3 273 276 PMID 11946525 doi 10 1016 0014 5793 72 80181 9 Jentsch J Meierkord S Hammer M The enzymes from carnivorous plants Nepenthes Properties and characterization of the acid protease nepenthacin Planta Medica 1989 55 227 doi 10 1055 s 2006 961979 3 0 3 1 3 2 EC 3 4 23 12 Nepenthesin 页面存档备份 存于互联网档案馆 Integrated Enzyme Database IntEnz Amagase S Nakayama S Tsugita A Acid protease in Nepenthes II Study on the specificity of nepenthesin J Biochem October 1969 66 4 431 9 PMID 5354017 Amagase S Digestive enzymes in insectivorous plants 3 Acid proteases in the genus Nepenthes and Drosera peltata J Biochem July 1972 72 1 73 81 PMID 5069751 Amagase S Mori M Nakayama S Digestive enzymes in insectivorous plants IV Enzymatic digestion of insects by Nepenthes secretion and Drosera peltata extract proteolytic and chitinolytic activities J Biochem September 1972 72 3 765 7 PMID 4634982 Tokes ZA Woon WC Chambers SM Digestive enzymes secreted by the carnivorous plant Nepenthes macferlanei L Planta March 1974 119 1 39 46 doi 10 1007 BF00390820 Athauda SBP Inoue H Iwamatsu A Takahashi K Acid Proteinase from Nepenthes distillatoria Badura James Michael 编 Aspartic proteinases retroviral and cellular enzymes New York Plenum 1998 453 458 ISBN 0 306 45809 8 Takahashi K Tanji M Shibata C Variations in the content and isozymic composition of nepenthesin in the pitcher fluids among Nepenthes species PDF Carnivorous Plant News Letter 2007 36 3 73 76 2011 12 10 原始内容存档 PDF 于2012 02 27 Kubota K Metoki Y Athauda SBP Shibata C Takahashi K Stability Profiles of Nepenthesin in Urea and Guanidine Hydrochloride Comparison with Porcine Pepsin A Bioscience Biotechnology and Biochemistry 2010 74 11 2323 2326 doi 10 1271 bbb 100391 Nakayama S Amagase S Acid Protease in Nepenthes Partial Purification and Properties of the Enzyme Proceedings of the Japan Academy 1968 44 5 358 362 永久失效連結 Athauda SB Matsumoto K Rajapakshe S Kuribayashi M Kojima M Kubomura Yoshida N Iwamatsu A Shibata C Inoue H Takahashi K Enzymic and structural characterization of nepenthesin a unique member of a novel subfamily of aspartic proteinases Biochem J July 2004 381 Pt 1 295 306 PMC 1133788 PMID 15035659 doi 10 1042 BJ20031575 扩展阅读 编辑The MEROPS online database for peptidases and their inhibitors A01 040 取自 https zh wikipedia org w index php title 猪笼草蛋白酶 amp oldid 69651478, 维基百科，wiki，书籍，书籍，图书馆，

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