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南天竹啡碱

南天竹啡碱(英语:Nantenine)是一种在南天竹[1]和一些紫堇属植物中发现的生物碱[2]它是α1-肾上腺素能受体[3]血清素5-HT2A受体的拮抗剂[4]可阻断MDMA对动物的行为和生理作用。[5]

南天竹啡碱
臨床資料
ATC碼
  • 未分配
识别信息
  • (S)-1,2-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinoline
CAS号2565-01-7  Y
PubChem CID
  • 197001
ChemSpider
  • 170619 N
UNII
  • XE0AU8C122
ChEMBL
  • ChEMBL467094 N
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
  • DTXSID70180343
化学信息
化学式C20H21NO4
摩尔质量339.39 g·mol−1
3D模型(JSmol英语JSmol
  • 交互式图像
  • CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=CC5=C(C=C43)OCO5)OC)OC
  • InChI=1S/C20H21NO4/c1-21-5-4-11-7-17(22-2)20(23-3)19-13-9-16-15(24-10-25-16)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m0/s1 N
  • Key:WSVWKHTVFGTTKJ-AWEZNQCLSA-N N

参见 编辑

参考资料 编辑

  1. ^ Shoji N, Umeyama A, Takemoto T, Ohizumi Y. Serotonergic receptor antagonist from Nandina domestica Thunberg. Journal of Pharmaceutical Sciences. April 1984, 73 (4): 568–70. PMID 6726648. doi:10.1002/jps.2600730435. 
  2. ^ Kiryakov HG, Iskrenova E, Daskalova E, Kuzmanov B, Evstatieva L. Alkaloids of Corydalis slivenensis. Planta Medica. March 1982, 44 (3): 168–70. PMID 17402105. doi:10.1055/s-2007-971432. 
  3. ^ Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Ohizumi Y. Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity. European Journal of Pharmacology. February 2002, 437 (3): 173–8. PMID 11890906. doi:10.1016/S0014-2999(02)01303-1. 
  4. ^ Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW. (+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners. Bioorganic & Medicinal Chemistry Letters. May 2009, 19 (9): 2530–2. PMC 2677726 . PMID 19328689. doi:10.1016/j.bmcl.2009.03.048. 
  5. ^ Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH. Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. Psychopharmacology. May 2004, 173 (3–4): 270–7. PMID 14740148. S2CID 8425621. doi:10.1007/s00213-003-1741-2. hdl:2027.42/46360 . 

Template:Navbox with collapsible groups

南天竹啡碱, 英语, nantenine, 是一种在南天竹, 和一些紫堇属植物中发现的生物碱, 它是α1, 肾上腺素能受体, 和血清素5, ht2a受体的拮抗剂, 可阻断mdma对动物的行为和生理作用, 臨床資料atc碼未分配识别信息iupac命名法, dimethoxy, methyl, tetrahydro, benzo, benzodioxolo, quinolinecas号2565, ypubchem, cid197001chemspider170619, nuniixe0au8c122chemblchem. 南天竹啡碱 英语 Nantenine 是一种在南天竹 1 和一些紫堇属植物中发现的生物碱 2 它是a1 肾上腺素能受体 3 和血清素5 HT2A受体的拮抗剂 4 可阻断MDMA对动物的行为和生理作用 5 南天竹啡碱臨床資料ATC碼未分配识别信息IUPAC命名法 S 1 2 Dimethoxy 6 methyl 5 6 6a 7 tetrahydro 4H benzo de 1 3 benzodioxolo 5 6 g quinolineCAS号2565 01 7 YPubChem CID197001ChemSpider170619 NUNIIXE0AU8C122ChEMBLChEMBL467094 NCompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID70180343化学信息化学式C 20H 21N O 4摩尔质量339 39 g mol 13D模型 JSmol 英语 JSmol 交互式图像SMILES CN1CCC2 CC C C3 C2 C H 1CC4 CC5 C C C43 OCO5 OC OCInChI InChI 1S C20H21NO4 c1 21 5 4 11 7 17 22 2 20 23 3 19 13 9 16 15 24 10 25 16 8 12 13 6 14 21 18 11 19 h7 9 14H 4 6 10H2 1 3H3 t14 m0 s1 NKey WSVWKHTVFGTTKJ AWEZNQCLSA N N参见 编辑阿朴吗啡 空褐麟碱 海罂粟碱 荷叶碱 Pukateine 千金藤啶碱 四氢黄藤素参考资料 编辑 Shoji N Umeyama A Takemoto T Ohizumi Y Serotonergic receptor antagonist from Nandina domestica Thunberg Journal of Pharmaceutical Sciences April 1984 73 4 568 70 PMID 6726648 doi 10 1002 jps 2600730435 Kiryakov HG Iskrenova E Daskalova E Kuzmanov B Evstatieva L Alkaloids of Corydalis slivenensis Planta Medica March 1982 44 3 168 70 PMID 17402105 doi 10 1055 s 2007 971432 Indra B Matsunaga K Hoshino O Suzuki M Ogasawara H Ohizumi Y Structure activity relationship studies with nantenine derivatives for alpha1 adrenoceptor antagonist activity European Journal of Pharmacology February 2002 437 3 173 8 PMID 11890906 doi 10 1016 S0014 2999 02 01303 1 Chaudhary S Pecic S Legendre O Navarro HA Harding WW Nantenine analogs as antagonists at human 5 HT 2A receptors C1 and flexible congeners Bioorganic amp Medicinal Chemistry Letters May 2009 19 9 2530 2 PMC 2677726 nbsp PMID 19328689 doi 10 1016 j bmcl 2009 03 048 Fantegrossi WE Kiessel CL Leach PT Van Martin C Karabenick RL Chen X Ohizumi Y Ullrich T Rice KC Woods JH Nantenine an antagonist of the behavioral and physiological effects of MDMA in mice Psychopharmacology May 2004 173 3 4 270 7 PMID 14740148 S2CID 8425621 doi 10 1007 s00213 003 1741 2 hdl 2027 42 46360 nbsp Template Navbox with collapsible groups nbsp 这是一篇作用於神经系统的藥品小作品 你可以通过编辑或修订扩充其内容 查论编 取自 https zh wikipedia org w index php title 南天竹啡碱 amp oldid 80544893, 维基百科,wiki,书籍,书籍,图书馆,

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