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维基百科

一叶萩碱

一叶萩碱(浅黄色晶体,化学式:C13H15NO2)是一种发现于一叶萩[1]珠子草[2]的生物碱。它具有促惊厥作用,[3][4]且具有强烈的痉挛作用,类似于士的宁[5]它是一种GABA-A拮抗剂。[6][7]

一叶萩碱
识别信息
  • (1S,2R,8S)-14-Oxa-7-azatetracyclo[6.6.1.01,11.02,7]pentadeca-9,11-dien-13-one
CAS号5610-40-2
PubChem CID
  • 442872
ChemSpider
  • 391181
UNII
  • G4VS580P5E
KEGG
  • C10614
ChEBI
  • CHEBI:9079
ChEMBL
  • ChEMBL303062
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
  • DTXSID7045944
ECHA InfoCard100.222.962
化学信息
化学式C13H15NO2
摩尔质量217.27 g·mol−1
3D模型(JSmol英语JSmol
  • 交互式图像
  • C1CCN2[C@H](C1)[C@]34C[C@H]2C=CC3=CC(=O)O4
  • InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1
  • Key:SWZMSZQQJRKFBP-WZRBSPASSA-N

参考文献 编辑

  1. ^ Wang DS, Fang LH, Du GH. Securinine. Natural small molecule drugs from plants. Springer Singapore. 2018: 325–330. ISBN 978-981-10-8021-0. doi:10.1007/978-981-10-8022-7_54. 
  2. ^ Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK. Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review. Journal of Ethnopharmacology. November 2011, 138 (2): 286–313. PMID 21982793. doi:10.1016/j.jep.2011.09.040. 
  3. ^ Tao, S. C.; Peng, J. Z.; Lu, M. W. Central convulsive action of l-securinine. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica. 1986, 7 (1): 9–12. PMID 2876581. 
  4. ^ Zhang, S. C.; Li, S. Z.; Gao, X. C.; Qian, L. H.; Yang, M. Z.; Yuan, H. N.; Tan, D. J. The adverse effects of the preparations of the active principles of Chinese herbal drugs. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 1993, 18 (7): 387–391. PMID 8267848. 
  5. ^ Klochkov, Sergey; Neganova, Margarita. Unique indolizidine alkaloid securinine is a promising scaffold for the development of neuroprotective and antitumor drugs. RSC Advances. 2021, 11 (31): 19185–19195. Bibcode:2021RSCAd..1119185K. PMC 9033663 . PMID 35478659. doi:10.1039/D1RA02558A . 
  6. ^ Securinine. PubChem, US National Library of Medicine. 2020-07-04 [2022-12-27]. (原始内容于2022-12-27). 
  7. ^ Beutler, J. A.; Karbon, E. W.; Brubaker, A. N.; Malik, R.; Curtis, D. R.; Enna, S. J. Securinine alkaloids: A new class of GABA receptor antagonist. Brain Research. 1985, 330 (1): 135–140. PMID 2985189. S2CID 21138482. doi:10.1016/0006-8993(85)90014-9. 

一叶萩碱, 浅黄色晶体, 化学式, c13h15no2, 是一种发现于一叶萩, 和珠子草, 的生物碱, 它具有促惊厥作用, 且具有强烈的痉挛作用, 类似于士的宁, 它是一种gaba, a拮抗剂, 识别信息iupac命名法, azatetracyclo, pentadeca, dien, onecas号5610, 2pubchem, cid442872chemspider391181uniig4vs580p5ekeggc10614chebichebi, 9079chemblchembl303062comptox, d. 一叶萩碱 浅黄色晶体 化学式 C13H15NO2 是一种发现于一叶萩 1 和珠子草 2 的生物碱 它具有促惊厥作用 3 4 且具有强烈的痉挛作用 类似于士的宁 5 它是一种GABA A拮抗剂 6 7 一叶萩碱识别信息IUPAC命名法 1S 2R 8S 14 Oxa 7 azatetracyclo 6 6 1 01 11 02 7 pentadeca 9 11 dien 13 oneCAS号5610 40 2PubChem CID442872ChemSpider391181UNIIG4VS580P5EKEGGC10614ChEBICHEBI 9079ChEMBLChEMBL303062CompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID7045944ECHA InfoCard100 222 962化学信息化学式C 13H 15N O 2摩尔质量217 27 g mol 13D模型 JSmol 英语 JSmol 交互式图像SMILES C1CCN2 C H C1 C 34C C H 2C CC3 CC O O4InChI InChI 1S C13H15NO2 c15 12 7 9 4 5 10 8 13 9 16 12 11 3 1 2 6 14 10 11 h4 5 7 10 11H 1 3 6 8H2 t10 11 13 m1 s1Key SWZMSZQQJRKFBP WZRBSPASSA N参考文献 编辑 Wang DS Fang LH Du GH Securinine Natural small molecule drugs from plants Springer Singapore 2018 325 330 ISBN 978 981 10 8021 0 doi 10 1007 978 981 10 8022 7 54 Patel JR Tripathi P Sharma V Chauhan NS Dixit VK Phyllanthus amarus ethnomedicinal uses phytochemistry and pharmacology a review Journal of Ethnopharmacology November 2011 138 2 286 313 PMID 21982793 doi 10 1016 j jep 2011 09 040 Tao S C Peng J Z Lu M W Central convulsive action of l securinine Zhongguo Yao Li Xue Bao Acta Pharmacologica Sinica 1986 7 1 9 12 PMID 2876581 Zhang S C Li S Z Gao X C Qian L H Yang M Z Yuan H N Tan D J The adverse effects of the preparations of the active principles of Chinese herbal drugs Zhongguo Zhong Yao Za Zhi Zhongguo Zhongyao Zazhi China Journal of Chinese Materia Medica 1993 18 7 387 391 PMID 8267848 Klochkov Sergey Neganova Margarita Unique indolizidine alkaloid securinine is a promising scaffold for the development of neuroprotective and antitumor drugs RSC Advances 2021 11 31 19185 19195 Bibcode 2021RSCAd 1119185K PMC 9033663 nbsp PMID 35478659 doi 10 1039 D1RA02558A nbsp Securinine PubChem US National Library of Medicine 2020 07 04 2022 12 27 原始内容存档于2022 12 27 Beutler J A Karbon E W Brubaker A N Malik R Curtis D R Enna S J Securinine alkaloids A new class of GABA receptor antagonist Brain Research 1985 330 1 135 140 PMID 2985189 S2CID 21138482 doi 10 1016 0006 8993 85 90014 9 取自 https zh wikipedia org w index php title 一叶萩碱 amp oldid 75667687, 维基百科,wiki,书籍,书籍,图书馆,

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