SIB-1757

SIB-1757是一种有机化合物，分子式C₁₂H₁₁N₃O，带有偶氮基团，可作为代谢型谷氨酸受体亚型mGluR₅的受体拮抗剂^[1]，在动物实验中存在抗痛觉过敏作用^[2]。

SIB-1757

识别信息
IUPAC命名法 6-methyl-2-(phenylazo)-3-pyridinol
CAS号	31993-01-8 ^Y
PubChem CID	6849066
ChemSpider	10654582
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID00425754
ECHA InfoCard	100.164.315
化学信息
化学式	C12H11N3O
摩尔质量	213.24 g·mol^−1
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES Oc1ccc(C)nc1\N=N\c2ccccc2
InChI InChI=1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+ Key:LOCPVWIREQIGNQ-CCEZHUSRSA-N

参考文献

1. Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veliçelebi G, Johnson EC. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. The Journal of Pharmacology and Experimental Therapeutics. July 1999, 290 (1): 170–81. PMID 10381773. 
2. Dogrul A, Ossipov MH, Lai J, Malan TP, Porreca F. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neuroscience Letters. October 2000, 292 (2): 115–8. PMID 10998562. doi:10.1016/S0304-3940(00)01458-0. 

外部链接