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维基百科

痛觉过敏

十二月 26, 2023

痛觉过敏是一种对痛过度敏感的异常状态，原因可能是伤害感受器或末梢神经受损，其中起到关键作用的化学物质为前列腺素E和F[1]。鸭嘴兽毒[2]、长期服用鸦片类药物[3]都会造成痛觉过敏。依照痛感发生部位的不同，它可分为原发性痛觉过敏和继发性痛觉过敏两种。

和神经性疼痛、触模痛等神经障碍引发的疼痛一样，痛觉过敏可以通过SSRI、三环抗抑郁药[4][5]、非甾体类抗炎药[6]、糖皮质激素[7]、加巴喷丁[8]、普瑞巴林[9]、NMDA受体拮抗剂[10][11][12] 来治疗。换用非典型鸦片类药物如曲马朵也有利于减缓病情[13]。

参考文献 编辑

  1. ^ Clinical Pharmacology. www.clinicalpharmacology-ip.com. [2017-06-25]. （原始内容于2019-12-10）. 
  2. ^ de Plater GM, Milburn PJ, Martin RL. Venom from the platypus, Ornithorhynchus anatinus, induces a calcium-dependent current in cultured dorsal root ganglion cells. J. Neurophysiol. March 2001, 85 (3): 1340–45 [2021-06-01]. PMID 11248005. doi:10.1152/jn.2001.85.3.1340. （原始内容于2021-07-21）. 
  3. ^ Chu LF, Angst MS, Clark D. Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin J Pain. 2008, 24 (6): 479–96. PMID 18574358. doi:10.1097/AJP.0b013e31816b2f43. 
  4. ^ Sindrup SH, Otto M, Finnerup NB, Jensen TS. Antidepressants in the treatment of neuropathic pain. Basic Clin. Pharmacol. Toxicol. June 2005, 96 (6): 399–409. PMID 15910402. doi:10.1111/j.1742-7843.2005.pto_96696601.x  . 
  5. ^ Matsuzawa-Yanagida K, Narita M, Nakajima M, et al. Usefulness of antidepressants for improving the neuropathic pain-like state and pain-induced anxiety through actions at different brain sites. Neuropsychopharmacology. July 2008, 33 (8): 1952–65. PMID 17957217. doi:10.1038/sj.npp.1301590. 
  6. ^ Koppert W, Wehrfritz A, Körber N, et al. The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans. Pain. March 2004, 108 (1–2): 148–53. PMID 15109518. doi:10.1016/j.pain.2003.12.017. 
  7. ^ Stubhaug A, Romundstad L, Kaasa T, Breivik H. Methylprednisolone and Ketorolac rapidly reduce hyperalgesia around a skin burn injury and increase pressure pain thresholds. Acta Anaesthesiol Scand. October 2007, 51 (9): 1138–46. PMID 17714578. doi:10.1111/j.1399-6576.2007.01415.x. 
  8. ^ Gottrup H, Juhl G, Kristensen AD, et al. Chronic oral Gabapentin reduces elements of central sensitization in human experimental Hyperalgesia.. Anesthesiology. December 2004, 101 (6): 1400–08. PMID 15564948. doi:10.1097/00000542-200412000-00021. 
  9. ^ Chizh BA, Göhring M, Tröster A, Quartey GK, Schmelz M, Koppert W. Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers. Br J Anaesth. February 2007, 98 (2): 246–54. PMID 17251214. doi:10.1093/bja/ael344  . 
  10. ^ Warncke T, Stubhaug A, Jørum E. Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary Hyperalgesia in man: a double-blind, cross-over comparison with morphine and placebo.. Pain. August 1997, 72 (1–2): 99–106. PMID 9272793. doi:10.1016/S0304-3959(97)00006-7. 
  11. ^ De Kock MF, Lavand'homme PM. The clinical role of NMDA receptor antagonists for the treatment of postoperative pain. Best Pract Res Clin Anaesthesiol. March 2007, 21 (1): 85–98. PMID 17489221. doi:10.1016/j.bpa.2006.12.006. 
  12. ^ Klein T, Magerl W, Hanschmann A, Althaus M, Treede RD. Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic Hyperalgesia.. Eur J Pain. January 2008, 12 (1): 17–29. PMID 17449306. doi:10.1016/j.ejpain.2007.02.002. 
  13. ^ Christoph T, Kögel B, Strassburger W, Schug SA. Tramadol has a better potency ratio relative to morphine in neuropathic than in nociceptive pain models. Drugs in R&D. 2007, 8 (1): 51–57. PMID 17249849. doi:10.2165/00126839-200708010-00005. 

外部链接 编辑

十二月 26, 2023
痛觉过敏, 是一种对痛过度敏感的异常状态, 原因可能是伤害感受器或末梢神经受损, 其中起到关键作用的化学物质为前列腺素e和f, 鸭嘴兽毒, 长期服用鸦片类药物, 都会造成, 依照痛感发生部位的不同, 它可分为原发性和继发性两种, 和神经性疼痛, 触模痛等神经障碍引发的疼痛一样, 可以通过ssri, 三环抗抑郁药, 非甾体类抗炎药, 糖皮质激素, 加巴喷丁, 普瑞巴林, nmda受体拮抗剂, 来治疗, 换用非典型鸦片类药物如曲马朵也有利于减缓病情, 参考文献, 编辑, clinical, pharmacology, . 痛觉过敏是一种对痛过度敏感的异常状态 原因可能是伤害感受器或末梢神经受损 其中起到关键作用的化学物质为前列腺素E和F 1 鸭嘴兽毒 2 长期服用鸦片类药物 3 都会造成痛觉过敏 依照痛感发生部位的不同 它可分为原发性痛觉过敏和继发性痛觉过敏两种 和神经性疼痛 触模痛等神经障碍引发的疼痛一样 痛觉过敏可以通过SSRI 三环抗抑郁药 4 5 非甾体类抗炎药 6 糖皮质激素 7 加巴喷丁 8 普瑞巴林 9 NMDA受体拮抗剂 10 11 12 来治疗 换用非典型鸦片类药物如曲马朵也有利于减缓病情 13 参考文献 编辑 Clinical Pharmacology www clinicalpharmacology ip com 2017 06 25 原始内容存档于2019 12 10 de Plater GM Milburn PJ Martin RL Venom from the platypus Ornithorhynchus anatinus induces a calcium dependent current in cultured dorsal root ganglion cells J Neurophysiol March 2001 85 3 1340 45 2021 06 01 PMID 11248005 doi 10 1152 jn 2001 85 3 1340 原始内容存档于2021 07 21 Chu LF Angst MS Clark D Opioid induced hyperalgesia in humans molecular mechanisms and clinical considerations Clin J Pain 2008 24 6 479 96 PMID 18574358 doi 10 1097 AJP 0b013e31816b2f43 Sindrup SH Otto M Finnerup NB Jensen TS Antidepressants in the treatment of neuropathic pain Basic Clin Pharmacol Toxicol June 2005 96 6 399 409 PMID 15910402 doi 10 1111 j 1742 7843 2005 pto 96696601 x nbsp Matsuzawa Yanagida K Narita M Nakajima M et al Usefulness of antidepressants for improving the neuropathic pain like state and pain induced anxiety through actions at different brain sites Neuropsychopharmacology July 2008 33 8 1952 65 PMID 17957217 doi 10 1038 sj npp 1301590 Koppert W Wehrfritz A Korber N et al The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans Pain March 2004 108 1 2 148 53 PMID 15109518 doi 10 1016 j pain 2003 12 017 Stubhaug A Romundstad L Kaasa T Breivik H Methylprednisolone and Ketorolac rapidly reduce hyperalgesia around a skin burn injury and increase pressure pain thresholds Acta Anaesthesiol Scand October 2007 51 9 1138 46 PMID 17714578 doi 10 1111 j 1399 6576 2007 01415 x Gottrup H Juhl G Kristensen AD et al Chronic oral Gabapentin reduces elements of central sensitization in human experimental Hyperalgesia Anesthesiology December 2004 101 6 1400 08 PMID 15564948 doi 10 1097 00000542 200412000 00021 Chizh BA Gohring M Troster A Quartey GK Schmelz M Koppert W Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers Br J Anaesth February 2007 98 2 246 54 PMID 17251214 doi 10 1093 bja ael344 nbsp Warncke T Stubhaug A Jorum E Ketamine an NMDA receptor antagonist suppresses spatial and temporal properties of burn induced secondary Hyperalgesia in man a double blind cross over comparison with morphine and placebo Pain August 1997 72 1 2 99 106 PMID 9272793 doi 10 1016 S0304 3959 97 00006 7 De Kock MF Lavand homme PM The clinical role of NMDA receptor antagonists for the treatment of postoperative pain Best Pract Res Clin Anaesthesiol March 2007 21 1 85 98 PMID 17489221 doi 10 1016 j bpa 2006 12 006 Klein T Magerl W Hanschmann A Althaus M Treede RD Antihyperalgesic and analgesic properties of the N methyl D aspartate NMDA receptor antagonist neramexane in a human surrogate model of neurogenic Hyperalgesia Eur J Pain January 2008 12 1 17 29 PMID 17449306 doi 10 1016 j ejpain 2007 02 002 Christoph T Kogel B Strassburger W Schug SA Tramadol has a better potency ratio relative to morphine in neuropathic than in nociceptive pain models Drugs in R amp D 2007 8 1 51 57 PMID 17249849 doi 10 2165 00126839 200708010 00005 外部链接 编辑 取自 https zh wikipedia org w index php title 痛觉过敏 amp oldid 69719815, 维基百科，wiki，书籍，书籍，图书馆，

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