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维基百科

S100蛋白

行進 26, 2023

S100蛋白（英語：S100 proteins）是一种脊椎动物的低分子量蛋白质家族，具有两个碱性螺旋-环-螺旋的钙结合位点（EF手型）。已知有21种不同的S100蛋白[1]。编码这些蛋白的基因家族的基因以S100为前缀，如S100A1, S100A2, S100A3等。 这一家族的蛋白也被视为是损伤相关分子模式（Damage-associated molecular pattern，DAMP）的分子。

S100/ICaBP type calcium binding domain
Structure of the S100B protein. Based on PyMOL rendering of PDB 1b4c.
鑑定
標誌S_100
PfamPF01023（旧版）
InterPro（英语：InterPro）IPR013787
PROSITE（英语：PROSITE）PDOC00275
SCOP（英语：Structural Classification of Proteins）1cnp / SUPFAM
現有可用的蛋白結構：
Pfam結構（旧版） / ECOD
PDBRCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）結構概要
PDB1yutB:9-52 1yuuA:9-52 1yusB:9-52

1yurA:9-52 1k8uA:5-50 1k9pA:5-50 1k96A:5-50 1k9kA:5-50 1cnpB:5-50 1a03A:5-50 2cnpB:5-50 1jwdB:5-50 1m31A:5-48 1k2hB:5-48 1cfpB:4-47 1psbA:4-47 1mho :4-47 1uwoA:4-47 1mq1B:4-47 1b4cB:4-47 1symA:4-47 1qlkB:4-47 1xydB:4-47 1dt7B:4-47 1mwnA:4-47 1j55A:4-47 1ozoA:4-47 1ksoA:5-48 1irjH:8-51 1xk4K:8-51 1gqmI:4-47 1odbD:4-47 1e8aB:4-47 1clb :5-46 1ig5A:5-46 2bca :5-46 1qx2B:5-46 1bod :5-46 1b1gA:5-46 1kcyA:5-46 1ht9A:5-46 2bcb :5-46 1n65A:5-46 1boc :5-46 3icb :5-46 1kqvA:5-46 1ksmA:5-46 1cdn :5-46 4icb :5-46 1igvA:5-46 1d1oA:5-46 1cb1 :4-46 1a4pB:5-45 1bt6A:5-45 1nshB:7-50 1v4zA:10-19 1v50A:10-19 1qlsA:8-51 1mr8B:5-48 1psrB:6-46

2psr :6-46 3psrA:6-46

相关的人类基因

  • S100A1，S100A2，S100A3，S100A4，S100A5，S100A6，S100A7（银屑病素）， S100A8，S100A9（8和9的异二聚体称为钙卫蛋白），S100A10，S100A11，S100A12（钙粒蛋白C），S100A13，S100A14，S100A15（koebnerisin），S100A16
  • S100B
  • S100P[2][3]


参考文献

  1. ^ Marenholz I, Heizmann CW, Fritz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem. Biophys. Res. Commun. October 2004, 322 (4): 1111–22. PMID 15336958. doi:10.1016/j.bbrc.2004.07.096. 
  2. ^ Penumutchu, Srinivasa R.; Chou, Ruey-Hwang; Yu, Chin. Structural Insights into Calcium-Bound S100P and the V Domain of the RAGE Complex. PLOS ONE. 2014-08-01, 9 (8): e103947 [2020-09-26]. ISSN 1932-6203. PMC 4118983  . PMID 25084534. doi:10.1371/journal.pone.0103947. （原始内容于2017-01-12）. 
  3. ^ Penumutchu, Srinivasa R.; Chou, Ruey-Hwang; Yu, Chin. Interaction between S100P and the anti-allergy drug cromolyn. Biochemical and Biophysical Research Communications. 2014-10-17, 454 (3): 404–409. ISSN 1090-2104. PMID 25450399. doi:10.1016/j.bbrc.2014.10.048. 

延伸阅读

  • Wolf R, Voscopoulos CJ, FitzGerald PC, et al. The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation. J. Invest. Dermatol. 2006, 126 (7): 1600–8. PMID 16528363. doi:10.1038/sj.jid.5700210. 
  • Ronald Wolf, O. M. Zack Howard, Hui-Fang Dong, Christopher Voscopoulos, Karen Boeshans, Jason Winston, Rao Divi, Michele Gunsior, Paul Goldsmith, Bijan Ahvazi, Triantafyllos Chavakis, Joost J. Oppenheim and Stuart H. Yuspa. Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A15.. The Journal of Immunology. 2010, 181 (2): 1499–1506. 
  • Ronald Wolf, Christopher Voscopoulos, Jason Winston, Alif Dharamsi, Paul Goldsmith Michele Gunsior, Barbara K. Vonderhaar, Melanie Olson, Peter H. Watson, and Stuart H. Yuspa. Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer.. J. Cancer Lett. 2008, 277 (1): 101–107. PMC 2680177  . PMID 19136201. doi:10.1016/j.canlet.2008.11.032. 
  • Ronald Wolf, Francesca Mascia, Alif Dharamsi, O. M. Zack Howard, Christophe Cataisson, Val Bliskovski, Jason Winston, Lionel Feigenbaum, Ulrike Lichti, Thomas Ruzicka Triantafyllos Chavakis, and Stuart H. Yuspa. Gene from a Psoriasis Susceptibility Locus Primes the Skin for Inflammation.. Science Translational Medicine. 2010, 2 (61): 61ra90. PMID 21148126. doi:10.1126/scitranslmed.3001108. 

外部链接

Template:Nerve tissue protein Template:Tumor markers

行進 26, 2023
s100蛋白, 英語, s100, proteins, 是一种脊椎动物的低分子量蛋白质家族, 具有两个碱性螺旋, 螺旋的钙结合位点, ef手型, 已知有21种不同的, 编码这些蛋白的基因家族的基因以s100为前缀, 如s100a1, s100a2, s100a3等, 这一家族的蛋白也被视为是损伤相关分子模式, damage, associated, molecular, pattern, damp, 的分子, s100, icabp, type, calcium, binding, domainstructure,. S100蛋白 英語 S100 proteins 是一种脊椎动物的低分子量蛋白质家族 具有两个碱性螺旋 环 螺旋的钙结合位点 EF手型 已知有21种不同的S100蛋白 1 编码这些蛋白的基因家族的基因以S100为前缀 如S100A1 S100A2 S100A3等 这一家族的蛋白也被视为是损伤相关分子模式 Damage associated molecular pattern DAMP 的分子 S100 ICaBP type calcium binding domainStructure of the S100B protein Based on PyMOL rendering of PDB 1b4c 鑑定標誌S 100PfamPF01023 旧版 InterPro 英语 InterPro IPR013787PROSITE 英语 PROSITE PDOC00275SCOP 英语 Structural Classification of Proteins 1cnp SUPFAM現有可用的蛋白結構 Pfam結構 旧版 ECODPDBRCSB PDB PDBe PDBjPDBsum 英语 PDBsum 結構概要PDB1yut B 9 52 1yuu A 9 52 1yus B 9 52 1yur A 9 52 1k8u A 5 50 1k9p A 5 50 1k96 A 5 50 1k9k A 5 50 1cnp B 5 50 1a03 A 5 50 2cnp B 5 50 1jwd B 5 50 1m31 A 5 48 1k2h B 5 48 1cfp B 4 47 1psb A 4 47 1mho 4 47 1uwo A 4 47 1mq1 B 4 47 1b4c B 4 47 1sym A 4 47 1qlk B 4 47 1xyd B 4 47 1dt7 B 4 47 1mwn A 4 47 1j55 A 4 47 1ozo A 4 47 1kso A 5 48 1irj H 8 51 1xk4 K 8 51 1gqm I 4 47 1odb D 4 47 1e8a B 4 47 1clb 5 46 1ig5 A 5 46 2bca 5 46 1qx2 B 5 46 1bod 5 46 1b1g A 5 46 1kcy A 5 46 1ht9 A 5 46 2bcb 5 46 1n65 A 5 46 1boc 5 46 3icb 5 46 1kqv A 5 46 1ksm A 5 46 1cdn 5 46 4icb 5 46 1igv A 5 46 1d1o A 5 46 1cb1 4 46 1a4p B 5 45 1bt6 A 5 45 1nsh B 7 50 1v4z A 10 19 1v50 A 10 19 1qls A 8 51 1mr8 B 5 48 1psr B 6 46 2psr 6 46 3psr A 6 46 目录 1 相关的人类基因 2 参考文献 3 延伸阅读 4 外部链接相关的人类基因 编辑S100A1 S100A2 S100A3 S100A4 S100A5 S100A6 S100A7 银屑病素 S100A8 S100A9 8和9的异二聚体称为钙卫蛋白 S100A10 S100A11 S100A12 钙粒蛋白C S100A13 S100A14 S100A15 koebnerisin S100A16 S100B S100P 2 3 参考文献 编辑 Marenholz I Heizmann CW Fritz G S100 proteins in mouse and man from evolution to function and pathology including an update of the nomenclature Biochem Biophys Res Commun October 2004 322 4 1111 22 PMID 15336958 doi 10 1016 j bbrc 2004 07 096 Penumutchu Srinivasa R Chou Ruey Hwang Yu Chin Structural Insights into Calcium Bound S100P and the V Domain of the RAGE Complex PLOS ONE 2014 08 01 9 8 e103947 2020 09 26 ISSN 1932 6203 PMC 4118983 PMID 25084534 doi 10 1371 journal pone 0103947 原始内容存档于2017 01 12 Penumutchu Srinivasa R Chou Ruey Hwang Yu Chin Interaction between S100P and the anti allergy drug cromolyn Biochemical and Biophysical Research Communications 2014 10 17 454 3 404 409 ISSN 1090 2104 PMID 25450399 doi 10 1016 j bbrc 2014 10 048 延伸阅读 编辑Wolf R Voscopoulos CJ FitzGerald PC et al The mouse S100A15 ortholog parallels genomic organization structure gene expression and protein processing pattern of the human S100A7 A15 subfamily during epidermal maturation J Invest Dermatol 2006 126 7 1600 8 PMID 16528363 doi 10 1038 sj jid 5700210 Ronald Wolf O M Zack Howard Hui Fang Dong Christopher Voscopoulos Karen Boeshans Jason Winston Rao Divi Michele Gunsior Paul Goldsmith Bijan Ahvazi Triantafyllos Chavakis Joost J Oppenheim and Stuart H Yuspa Chemotactic Activity of S100A7 Psoriasin Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A15 The Journal of Immunology 2010 181 2 1499 1506 Ronald Wolf Christopher Voscopoulos Jason Winston Alif Dharamsi Paul Goldsmith Michele Gunsior Barbara K Vonderhaar Melanie Olson Peter H Watson and Stuart H Yuspa Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer J Cancer Lett 2008 277 1 101 107 PMC 2680177 PMID 19136201 doi 10 1016 j canlet 2008 11 032 Ronald Wolf Francesca Mascia Alif Dharamsi O M Zack Howard Christophe Cataisson Val Bliskovski Jason Winston Lionel Feigenbaum Ulrike Lichti Thomas Ruzicka Triantafyllos Chavakis and Stuart H Yuspa Gene from a Psoriasis Susceptibility Locus Primes the Skin for Inflammation Science Translational Medicine 2010 2 61 61ra90 PMID 21148126 doi 10 1126 scitranslmed 3001108 外部链接 编辑醫學主題詞表 MeSH S100 ProteinsTemplate Nerve tissue protein Template Tumor markers 取自 https zh wikipedia org w index php title S100蛋白 amp oldid 68867169, 维基百科，wiki，书籍，书籍，图书馆，

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