^Yin Z, Chen YL, Schul W, Wang QY, Gu F, Duraiswamy J, et al. An adenosine nucleoside inhibitor of dengue virus. Proceedings of the National Academy of Sciences of the United States of America. December 2009, 106 (48): 20435–9. Bibcode:2009PNAS..10620435Y. PMC 2787148. PMID 19918064. doi:10.1073/pnas.0907010106.
^Lo MK, Shi PY, Chen YL, Flint M, Spiropoulou CF. In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. Antiviral Research. June 2016, 130: 46–9. PMC 5096641. PMID 27016316. doi:10.1016/j.antiviral.2016.03.013.
^Deng YQ, Zhang NN, Li CF, Tian M, Hao JN, Xie XP, et al. Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus. Open Forum Infectious Diseases. October 2016, 3 (4): ofw175. PMC 5063548. PMID 27747251. doi:10.1093/ofid/ofw175.
^Nelson J, Roe K, Orillo B, Shi PY, Verma S. Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection. Antiviral Research. October 2015, 122: 39–45. PMC 4853296. PMID 26225754. doi:10.1016/j.antiviral.2015.07.008.
四月 07, 2024
nitd008, 是一种抗病毒药物, 属于腺苷类似物, 一种核苷类似物, 英语, nucleoside, analog, 它作为治疗黄病毒, 英语, flavivirus, 感染的潜在药物被开发, 并显示出对很多相关病毒的广谱活性, 如骨痛热症病毒, 西尼羅河病毒, 黄热病病毒, 波瓦桑病毒, 英语, powassan, virus, 丙肝病毒, 克亚萨努尔森林病病毒, 英语, 克亚萨努尔森林病病毒, 鄂木斯克出血热病毒, 英语, omsk, hemorrhagic, fever, virus, 和茲卡病毒, 然而. NITD008是一种抗病毒药物 属于腺苷类似物 一种核苷类似物 英语 nucleoside analog 它作为治疗黄病毒 英语 flavivirus 感染的潜在药物被开发 并显示出对很多相关病毒的广谱活性 如骨痛热症病毒 西尼羅河病毒 黄热病病毒 波瓦桑病毒 英语 Powassan virus 丙肝病毒 克亚萨努尔森林病病毒 英语 克亚萨努尔森林病病毒 鄂木斯克出血热病毒 英语 Omsk hemorrhagic fever virus 和茲卡病毒 1 2 3 然而 虽然NITD008在临床前的动物试验中显示出较大毒性 不适合人体试验 但是它仍被用于新型病毒性疾病治疗的研究中 4 NITD008臨床資料商品名 英语 Drug nomenclature NITD008识别信息IUPAC命名法 2R 3R 4R 5R 2 4 Amino 7H pyrrolo 2 3 d pyrimidin 7 yl 3 ethynyl 5 hydroxymethyl tetrahydrofuran 3 4 diolCAS号1044589 82 3 YPubChem CID44633776ChemSpider26376187UNIILKI7T3WQ2EChEMBLChEMBL1630221化学信息化学式C 13H 14N 4O 4摩尔质量290 28 g mol 13D模型 JSmol 英语 JSmol 交互式图像SMILES C C C 1 C H C H O C H 1N2C CC3 C2N CN C3N CO O OInChI InChI 1S C13H14N4O4 c1 2 13 20 9 19 8 5 18 21 12 13 17 4 3 7 10 14 15 6 16 11 7 17 h1 3 4 6 8 9 12 18 20H 5H2 H2 14 15 16 t8 9 12 13 m1 s1Key NKRAIOQPSBRMOV NRMKKVEVSA N参考文献 编辑 Yin Z Chen YL Schul W Wang QY Gu F Duraiswamy J et al An adenosine nucleoside inhibitor of dengue virus Proceedings of the National Academy of Sciences of the United States of America December 2009 106 48 20435 9 Bibcode 2009PNAS 10620435Y PMC 2787148 nbsp PMID 19918064 doi 10 1073 pnas 0907010106 nbsp Lo MK Shi PY Chen YL Flint M Spiropoulou CF In vitro antiviral activity of adenosine analog NITD008 against tick borne flaviviruses Antiviral Research June 2016 130 46 9 PMC 5096641 nbsp PMID 27016316 doi 10 1016 j antiviral 2016 03 013 Deng YQ Zhang NN Li CF Tian M Hao JN Xie XP et al Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus Open Forum Infectious Diseases October 2016 3 4 ofw175 PMC 5063548 nbsp PMID 27747251 doi 10 1093 ofid ofw175 nbsp Nelson J Roe K Orillo B Shi PY Verma S Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection Antiviral Research October 2015 122 39 45 PMC 4853296 nbsp PMID 26225754 doi 10 1016 j antiviral 2015 07 008 取自 https zh wikipedia org w index php title NITD008 amp oldid 68333387, 维基百科，wiki，书籍，书籍，图书馆，
