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维基百科

COS-7

十二月 12, 2023

COS-7 (亦稱ATCC CRL-1651、CV-1 in Origin Simian-7) 是在1980年代初期發現的非洲綠猴腎細胞系，最初是經帶有編碼野生型T抗原的起始失活突變的猿猴空泡病毒40轉染而建立[1][2]，具有成纖維細胞樣和病毒敏感性的獨特特徵[1][2]。穩定的細胞系是轉運體相互作用研究及體外評價藥物候選物的理想模型，其中常用的其中一個宿主細胞系就是COS-7細胞。COS-7細胞也會應用在細胞基因轉錄的研究及DNA質體轉染實驗[3]，從而分析類固醇生成基因[4]、類固醇受體的功能[5]及類固醇對功能分子的作用[6]。COS-7是源自非類固醇生成器官的非類固醇生成細胞[7][8]，然而有研究表明COS-7細胞可將3H-睪酮代謝為3H-雄烯二酮[9]。

COS-7細胞

參考資料 编辑

  1. ^ 1.0 1.1 Gluzman, Y. SV40-transformed simian cells support the replication of early SV40 mutants.. Cell. 1981-01, 23 (1): 175–82 [2019-12-08]. PMID 6260373. doi:10.1016/0092-8674(81)90282-8. 
  2. ^ 2.0 2.1 Mellon, P; Parker, V; Gluzman, Y; Maniatis, T. Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system.. Cell. 1981-12, 27 (2 Pt 1): 279–88 [2019-12-08]. PMID 6277501. doi:10.1016/0092-8674(81)90411-6. 
  3. ^ Smale, ST; Baltimore, D. The "initiator" as a transcription control element.. Cell. 1989-04-07, 57 (1): 103–13 [2019-12-08]. PMID 2467742. doi:10.1016/0092-8674(89)90176-1. 
  4. ^ Kawamoto, T; Mitsuuchi, Y; Toda, K; Yokoyama, Y; Miyahara, K; Miura, S; Ohnishi, T; Ichikawa, Y; Nakao, K; Imura, H. Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.. Proceedings of the National Academy of Sciences of the United States of America. 1992-02-15, 89 (4): 1458–62 [2019-12-08]. PMID 1741400. doi:10.1073/pnas.89.4.1458. 
  5. ^ Simental, JA; Sar, M; Lane, MV; French, FS; Wilson, EM. Transcriptional activation and nuclear targeting signals of the human androgen receptor.. The Journal of biological chemistry. 1991-01-05, 266 (1): 510–8 [2019-12-08]. PMID 1985913. 
  6. ^ Topor, LS; Asai, M; Dunn, J; Majzoub, JA. Cortisol stimulates secretion of dehydroepiandrosterone in human adrenocortical cells through inhibition of 3betaHSD2.. The Journal of clinical endocrinology and metabolism. 2011-01, 96 (1): E31–9 [2019-12-08]. PMID 20943790. doi:10.1210/jc.2010-0692. 
  7. ^ West, LA; Horvat, RD; Roess, DA; Barisas, BG; Juengel, JL; Niswender, GD. Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane.. Endocrinology. 2001-01, 142 (1): 502–5 [2019-12-08]. PMID 11145616. doi:10.1210/endo.142.1.8052. 
  8. ^ Rasheeda, MK; Kagawa, H; Kirubagaran, R; Dutta-Gupta, A; Senthilkumaran, B. Cloning, expression and enzyme activity analysis of testicular 11beta-hydroxysteroid dehydrogenase during seasonal cycle and after hCG induction in air-breathing catfish Clarias gariepinus.. The Journal of steroid biochemistry and molecular biology. 2010-05, 120 (1): 1–10 [2019-12-08]. PMID 20219674. doi:10.1016/j.jsbmb.2010.02.014. 
  9. ^ Nozaki, M; Haraguchi, S; Miyazaki, T; Shigeta, D; Kano, N; Lei, XF; Kim-Kaneyama, JR; Minakata, H; Miyazaki, A; Tsutsui, K. Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells.. Scientific reports. 2018-02-01, 8 (1): 2167 [2019-12-08]. PMID 29391479. doi:10.1038/s41598-018-20226-2. 

外部連結 编辑

十二月 12, 2023
亦稱atcc, 1651, origin, simian, 是在1980年代初期發現的非洲綠猴腎細胞系, 最初是經帶有編碼野生型t抗原的起始失活突變的猿猴空泡病毒40轉染而建立, 具有成纖維細胞樣和病毒敏感性的獨特特徵, 穩定的細胞系是轉運體相互作用研究及體外評價藥物候選物的理想模型, 其中常用的其中一個宿主細胞系就是細胞, 細胞也會應用在細胞基因轉錄的研究及dna質體轉染實驗, 從而分析類固醇生成基因, 類固醇受體的功能, 及類固醇對功能分子的作用, 是源自非類固醇生成器官的非類固醇生成細胞, 然而有研究表明細胞. COS 7 亦稱ATCC CRL 1651 CV 1 in Origin Simian 7 是在1980年代初期發現的非洲綠猴腎細胞系 最初是經帶有編碼野生型T抗原的起始失活突變的猿猴空泡病毒40轉染而建立 1 2 具有成纖維細胞樣和病毒敏感性的獨特特徵 1 2 穩定的細胞系是轉運體相互作用研究及體外評價藥物候選物的理想模型 其中常用的其中一個宿主細胞系就是COS 7細胞 COS 7細胞也會應用在細胞基因轉錄的研究及DNA質體轉染實驗 3 從而分析類固醇生成基因 4 類固醇受體的功能 5 及類固醇對功能分子的作用 6 COS 7是源自非類固醇生成器官的非類固醇生成細胞 7 8 然而有研究表明COS 7細胞可將3H 睪酮代謝為3H 雄烯二酮 9 COS 7細胞參考資料 编辑 1 0 1 1 Gluzman Y SV40 transformed simian cells support the replication of early SV40 mutants Cell 1981 01 23 1 175 82 2019 12 08 PMID 6260373 doi 10 1016 0092 8674 81 90282 8 2 0 2 1 Mellon P Parker V Gluzman Y Maniatis T Identification of DNA sequences required for transcription of the human alpha 1 globin gene in a new SV40 host vector system Cell 1981 12 27 2 Pt 1 279 88 2019 12 08 PMID 6277501 doi 10 1016 0092 8674 81 90411 6 Smale ST Baltimore D The initiator as a transcription control element Cell 1989 04 07 57 1 103 13 2019 12 08 PMID 2467742 doi 10 1016 0092 8674 89 90176 1 Kawamoto T Mitsuuchi Y Toda K Yokoyama Y Miyahara K Miura S Ohnishi T Ichikawa Y Nakao K Imura H Role of steroid 11 beta hydroxylase and steroid 18 hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans Proceedings of the National Academy of Sciences of the United States of America 1992 02 15 89 4 1458 62 2019 12 08 PMID 1741400 doi 10 1073 pnas 89 4 1458 Simental JA Sar M Lane MV French FS Wilson EM Transcriptional activation and nuclear targeting signals of the human androgen receptor The Journal of biological chemistry 1991 01 05 266 1 510 8 2019 12 08 PMID 1985913 Topor LS Asai M Dunn J Majzoub JA Cortisol stimulates secretion of dehydroepiandrosterone in human adrenocortical cells through inhibition of 3betaHSD2 The Journal of clinical endocrinology and metabolism 2011 01 96 1 E31 9 2019 12 08 PMID 20943790 doi 10 1210 jc 2010 0692 West LA Horvat RD Roess DA Barisas BG Juengel JL Niswender GD Steroidogenic acute regulatory protein and peripheral type benzodiazepine receptor associate at the mitochondrial membrane Endocrinology 2001 01 142 1 502 5 2019 12 08 PMID 11145616 doi 10 1210 endo 142 1 8052 Rasheeda MK Kagawa H Kirubagaran R Dutta Gupta A Senthilkumaran B Cloning expression and enzyme activity analysis of testicular 11beta hydroxysteroid dehydrogenase during seasonal cycle and after hCG induction in air breathing catfish Clarias gariepinus The Journal of steroid biochemistry and molecular biology 2010 05 120 1 1 10 2019 12 08 PMID 20219674 doi 10 1016 j jsbmb 2010 02 014 Nozaki M Haraguchi S Miyazaki T Shigeta D Kano N Lei XF Kim Kaneyama JR Minakata H Miyazaki A Tsutsui K Expression of steroidogenic enzymes and metabolism of steroids in COS 7 cells known as non steroidogenic cells Scientific reports 2018 02 01 8 1 2167 2019 12 08 PMID 29391479 doi 10 1038 s41598 018 20226 2 外部連結 编辑Cellosaurus entry for COS 7 页面存档备份 存于互联网档案馆 取自 https zh wikipedia org w index php title COS 7 amp oldid 70123127, 维基百科，wiki，书籍，书籍，图书馆，

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