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^Maqsood MI, Matin MM, Bahrami AR, Ghasroldasht MM. Immortality of cell lines: challenges and advantages of establishment. Cell Biology International. October 2013, 37 (10): 1038–45. PMID 23723166. S2CID 14777249. doi:10.1002/cbin.10137.
^Skloot, Rebecca. Henrietta's Dance. Johns Hopkins Magazine. [5 April 2021]. （原始内容于2021-11-30）. Isolation from a naturally occurring cancer. This is the original method for generating an immortalised cell line. Major examples include human HeLa, the line is derived from cervical cancer cells taken on February 8, 1951 from Henrietta Lacks, a 31-year-old African-American mother of five, who died of cancer on October 4, 1951.
^Henle W, Henle G. Epidemiologic aspects of Epstein-Barr virus (EBV)-associated diseases. Annals of the New York Academy of Sciences. 1980, 354: 326–31. PMID 6261650. S2CID 30025994. doi:10.1111/j.1749-6632.1980.tb27975.x. Introduction of a viral gene that partially deregulates the cell cycle (e.g., the adenovirus type 5 E1 gene was used to immortalise the HEK 293 cell line; the Epstein-Barr virus can immortalise B lymphocytes by infection
^Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. January 1998, 279 (5349): 349–52. Bibcode:1998Sci...279..349B. PMID 9454332. doi:10.1126/science.279.5349.349.已忽略文本“Artificial expression of key proteins required for immortality, for example telomerase which prevents degradation of chromosome ends during DNA replication in eukaryotes.” (帮助)
^Kwakkenbos MJ, van Helden PM, Beaumont T, Spits H. Stable long-term cultures of self-renewing B cells and their applications. Immunological Reviews. March 2016, 270 (1): 65–77. PMC 4755196. PMID 26864105. doi:10.1111/imr.12395. Hybridoma technology, specifically used for generating immortalised antibody-producing B cell lines, where an antibody-producing B cell is fused with a myeloma (B cell cancer) cell.
永生細胞系, 是指一組在多細胞生命中的细胞群, 因為基因突變, 已經逃避了正常的細胞衰老, 而是可以繼續進行分裂, 甚至無限無止境地繁殖, 細胞可以在體外長時間生長, 可以來自自然發生的突變, 例如癌細胞, 也可以出於實驗目的有意誘導, 永生細胞係是研究多細胞生物的生物化學和細胞生物學的非常重要的工具, 也用於生物技術, 值得留意的是, 幹細胞雖然可以不斷分裂繁殖, 但不屬, 目前著名的包括海拉細胞, 參考, 编辑, skloot, immortal, life, henrietta, lacks, random,. 永生細胞系 是指一組在多細胞生命中的细胞群 因為基因突變 已經逃避了正常的細胞衰老 而是可以繼續進行分裂 甚至無限無止境地繁殖 細胞可以在體外長時間生長 永生細胞系 可以來自自然發生的突變 例如癌細胞 也可以出於實驗目的有意誘導 永生細胞係是研究多細胞生物的生物化學和細胞生物學的非常重要的工具 永生細胞系也用於生物技術 值得留意的是 幹細胞雖然可以不斷分裂繁殖 但不屬永生細胞系 目前著名的永生細胞系包括海拉細胞 1 2 3 4 5 6 參考 编辑 Skloot R Immortal Life of Henrietta Lacks the Random House 2010 2020 09 20 ISBN 978 0 307 71253 0 OCLC 974000732 Maqsood MI Matin MM Bahrami AR Ghasroldasht MM Immortality of cell lines challenges and advantages of establishment Cell Biology International October 2013 37 10 1038 45 PMID 23723166 S2CID 14777249 doi 10 1002 cbin 10137 Skloot Rebecca Henrietta s Dance Johns Hopkins Magazine 5 April 2021 原始内容存档于2021 11 30 Isolation from a naturally occurring cancer This is the original method for generating an immortalised cell line Major examples include human HeLa the line is derived from cervical cancer cells taken on February 8 1951 from Henrietta Lacks a 31 year old African American mother of five who died of cancer on October 4 1951 Henle W Henle G Epidemiologic aspects of Epstein Barr virus EBV associated diseases Annals of the New York Academy of Sciences 1980 354 326 31 PMID 6261650 S2CID 30025994 doi 10 1111 j 1749 6632 1980 tb27975 x Introduction of a viral gene that partially deregulates the cell cycle e g the adenovirus type 5 E1 gene was used to immortalise the HEK 293 cell line the Epstein Barr virus can immortalise B lymphocytes by infection Bodnar AG Ouellette M Frolkis M Holt SE Chiu CP Morin GB et al Extension of life span by introduction of telomerase into normal human cells Science January 1998 279 5349 349 52 Bibcode 1998Sci 279 349B PMID 9454332 doi 10 1126 science 279 5349 349 已忽略文本 Artificial expression of key proteins required for immortality for example telomerase which prevents degradation of chromosome ends during DNA replication in eukaryotes 帮助 Kwakkenbos MJ van Helden PM Beaumont T Spits H Stable long term cultures of self renewing B cells and their applications Immunological Reviews March 2016 270 1 65 77 PMC 4755196 PMID 26864105 doi 10 1111 imr 12395 Hybridoma technology specifically used for generating immortalised antibody producing B cell lines where an antibody producing B cell is fused with a myeloma B cell cancer cell 參見 编辑癌細胞 海拉細胞 多細胞生物 取自 https zh wikipedia org w index php title 永生細胞系 amp oldid 72832061, 维基百科，wiki，书籍，书籍，图书馆，
