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维基百科

6-溴-1-己醇

一月 05, 2023

6-溴-1-己醇是一种有机化合物，化学式为Br(CH2)6OH。它可由1,6-己二醇和氢溴酸回流得到。[3]

6-溴-1-己醇
英文名 6-bromo-1-hexanol
别名 6-溴正己醇
ω-溴-1-己醇
识别
CAS号 4286-55-9  
PubChem 77970
SMILES
性质
化学式 C6H13BrO
摩尔质量 181.07 g·mol−1
密度 1.3628 g·cm−3（20 °C）[1]
沸点 105－106 °C（378－379 K）（5 Torr）[2]
若非注明，所有数据均出自一般条件（25 ℃，100 kPa）下。

反应

6-溴-1-己醇和叠氮化钠在N,N-二甲基甲酰胺中反应，可以得到6-叠氮基-1-己醇。[4]

6-溴-1-己醇和苯酚在碳酸钾的存在下（碘化钾催化）于丙酮中反应，可以得到6-苯氧基-1-己醇；[5]它和二乙胺在相似条件下于N,N-二甲基甲酰胺中反应，得到6-二乙氨基-1-己醇。[6]它和三苯基膦在乙腈中反应，得到季𬭸盐(6-羟己基)三苯基溴化𬭸。[7]

6-溴-1-己醇和联硼酸频哪醇酯在氯化三(三苯基膦)合钴(I)的催化下反应，生成羟己基硼酸频哪醇酯，可用作有机试剂。[8]

 

该化合物有羟基，具有醇的通性。如和乙酰氯发生酯化反应，生成乙酸-6-溴己酯[9]；可以被PCC等氧化剂氧化为相应的醛[10]等。

参考文献

  1. ^ Kurbanli, Kamuran; Ahmetli, Gulnare; Tarlan, Esra. Synthesis of biologically active and environmental friendly insect pesticides: pheromones. Asian Journal of Chemistry, 2009. 21 (3): 1903-1909. ISSN: 0970-7077.
  2. ^ Degering, Ed. F.; Boatright, Leslie G. Studies on the Synthesis of Lysine1. Journal of the American Chemical Society. 1950, 72 (11): 5137–5139. ISSN 0002-7863. doi:10.1021/ja01167a091. 
  3. ^ Oliveira, Adeildo Junior; Souza, Isis Torres; Bernardo, Vanderson Barbosa; Santos, Larissa C.; Lima, Maria Raquel Ferreira; Goulart, Henrique Fonseca; Goulart Santana, Antônio Euzébio. Monobromination of α, ω‐Diols: Highly Efficient Preparation of Synthetic Intermediates. ChemistrySelect. 2019, 4 (36): 10843–10845. ISSN 2365-6549. doi:10.1002/slct.201901879. 
  4. ^ Ma, Le-Le; Liu, Ming-Xuan; Liu, Xu-Ying; Sun, Wan; Lu, Zhong-Lin; Gao, Yong-Guang; He, Lan. Macrocyclic polyamine [12]aneN3 modified triphenylamine-pyrazine derivatives as efficient non-viral gene vectors with AIE and two-photon imaging properties. Journal of Materials Chemistry B. 2020, 8 (17): 3869–3879. ISSN 2050-750X. doi:10.1039/D0TB00321B. 
  5. ^ Kumar, Bijari Anil; Nayak, Rati Ranjan. Supramolecular phenoxy-alkyl maleate-based hydrogels and their enzyme/pH-responsive curcumin release. New Journal of Chemistry. 2019, 43 (14): 5559–5567. ISSN 1144-0546. doi:10.1039/C8NJ05796F. 
  6. ^ Luo, Li; Song, Qing; Li, Yan; Cao, Zhongcheng; Qiang, Xiaoming; Tan, Zhenghuai; Deng, Yong. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease. Bioorganic & Medicinal Chemistry. 2020, 28 (8): 115400. ISSN 0968-0896. doi:10.1016/j.bmc.2020.115400. 
  7. ^ Zhao, Xuan; Huang, Yuchao; Yuan, Gankun; Zuo, Ke; Huang, Yafan; Chen, Juanjuan; Li, Jinyu; Xue, Jinping. A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activities. Chemical Communications. 2019, 55 (6): 866–869. ISSN 1359-7345. doi:10.1039/C8CC09456J. 
  8. ^ Verma, Piyush Kumar; Prasad, K. Sujit; Varghese, Dominic; Geetharani, K. Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides. Organic Letters. 2020, 22 (4): 1431–1436. ISSN 1523-7060. doi:10.1021/acs.orglett.0c00038. 
  9. ^ Iwasaki, Tomoya; Tajimi, Yuka; Kameda, Kenta; Kingwell, Callum; Wcislo, William; Osaka, Kazuyuki; Yamawaki, Mugen; Morita, Toshio; Yoshimi, Yasuharu. Synthesis of 23-, 25-, 27-, and 29-Membered (Z)-Selective Unsaturated and Saturated Macrocyclic Lactones from 16- and 17-Membered Macrocyclic Lactones and Bromoalcohols by Wittig Reaction, Yamaguchi Macrolactonization, and Photoinduced Decarboxylative Radical Macrolactonization. The Journal of Organic Chemistry. 2019, 84 (12): 8019–8026. ISSN 0022-3263. doi:10.1021/acs.joc.9b00870. 
  10. ^ Yang, Bo; Lu, Zhan. Visible-Light-Promoted Oxidative [4 + 2] Cycloadditions of Aryl Silyl Enol Ethers. The Journal of Organic Chemistry. 2016, 81 (16): 7288–7300. ISSN 0022-3263. doi:10.1021/acs.joc.6b01016. 

一月 05, 2023
己醇, 是一种有机化合物, 化学式为br, 它可由1, 己二醇和氢溴酸回流得到, 英文名, bromo, hexanol别名, 溴正己醇ω, 己醇识别cas号, 4286, pubchem, 77970smiles, brcccccco性质化学式, c6h13bro摩尔质量, 1密度, 3628, 沸点, torr, 若非注明, 所有数据均出自一般条件, 反应, 编辑和叠氮化钠在n, 二甲基甲酰胺中反应, 可以得到6, 叠氮基, 己醇, 和苯酚在碳酸钾的存在下, 碘化钾催化, 于丙酮中反应, 可以得到6, 苯氧基,. 6 溴 1 己醇是一种有机化合物 化学式为Br CH2 6OH 它可由1 6 己二醇和氢溴酸回流得到 3 6 溴 1 己醇英文名 6 bromo 1 hexanol别名 6 溴正己醇w 溴 1 己醇识别CAS号 4286 55 9 PubChem 77970SMILES BrCCCCCCO性质化学式 C6H13BrO摩尔质量 181 07 g mol 1密度 1 3628 g cm 3 20 C 1 沸点 105 106 C 378 379 K 5 Torr 2 若非注明 所有数据均出自一般条件 25 100 kPa 下 反应 编辑6 溴 1 己醇和叠氮化钠在N N 二甲基甲酰胺中反应 可以得到6 叠氮基 1 己醇 4 6 溴 1 己醇和苯酚在碳酸钾的存在下 碘化钾催化 于丙酮中反应 可以得到6 苯氧基 1 己醇 5 它和二乙胺在相似条件下于N N 二甲基甲酰胺中反应 得到6 二乙氨基 1 己醇 6 它和三苯基膦在乙腈中反应 得到季𬭸盐 6 羟己基 三苯基溴化𬭸 7 6 溴 1 己醇和联硼酸频哪醇酯在氯化三 三苯基膦 合钴 I 的催化下反应 生成羟己基硼酸频哪醇酯 可用作有机试剂 8 该化合物有羟基 具有醇的通性 如和乙酰氯发生酯化反应 生成乙酸 6 溴己酯 9 可以被PCC等氧化剂氧化为相应的醛 10 等 参考文献 编辑 Kurbanli Kamuran Ahmetli Gulnare Tarlan Esra Synthesis of biologically active and environmental friendly insect pesticides pheromones Asian Journal of Chemistry 2009 21 3 1903 1909 ISSN 0970 7077 Degering Ed F Boatright Leslie G Studies on the Synthesis of Lysine1 Journal of the American Chemical Society 1950 72 11 5137 5139 ISSN 0002 7863 doi 10 1021 ja01167a091 Oliveira Adeildo Junior Souza Isis Torres Bernardo Vanderson Barbosa Santos Larissa C Lima Maria Raquel Ferreira Goulart Henrique Fonseca Goulart Santana Antonio Euzebio Monobromination of a w Diols Highly Efficient Preparation of Synthetic Intermediates ChemistrySelect 2019 4 36 10843 10845 ISSN 2365 6549 doi 10 1002 slct 201901879 Ma Le Le Liu Ming Xuan Liu Xu Ying Sun Wan Lu Zhong Lin Gao Yong Guang He Lan Macrocyclic polyamine 12 aneN3 modified triphenylamine pyrazine derivatives as efficient non viral gene vectors with AIE and two photon imaging properties Journal of Materials Chemistry B 2020 8 17 3869 3879 ISSN 2050 750X doi 10 1039 D0TB00321B Kumar Bijari Anil Nayak Rati Ranjan Supramolecular phenoxy alkyl maleate based hydrogels and their enzyme pH responsive curcumin release New Journal of Chemistry 2019 43 14 5559 5567 ISSN 1144 0546 doi 10 1039 C8NJ05796F Luo Li Song Qing Li Yan Cao Zhongcheng Qiang Xiaoming Tan Zhenghuai Deng Yong Design synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer s disease Bioorganic amp Medicinal Chemistry 2020 28 8 115400 ISSN 0968 0896 doi 10 1016 j bmc 2020 115400 Zhao Xuan Huang Yuchao Yuan Gankun Zuo Ke Huang Yafan Chen Juanjuan Li Jinyu Xue Jinping A novel tumor and mitochondria dual targeted photosensitizer showing ultra efficient photodynamic anticancer activities Chemical Communications 2019 55 6 866 869 ISSN 1359 7345 doi 10 1039 C8CC09456J Verma Piyush Kumar Prasad K Sujit Varghese Dominic Geetharani K Cobalt I Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides Organic Letters 2020 22 4 1431 1436 ISSN 1523 7060 doi 10 1021 acs orglett 0c00038 Iwasaki Tomoya Tajimi Yuka Kameda Kenta Kingwell Callum Wcislo William Osaka Kazuyuki Yamawaki Mugen Morita Toshio Yoshimi Yasuharu Synthesis of 23 25 27 and 29 Membered Z Selective Unsaturated and Saturated Macrocyclic Lactones from 16 and 17 Membered Macrocyclic Lactones and Bromoalcohols by Wittig Reaction Yamaguchi Macrolactonization and Photoinduced Decarboxylative Radical Macrolactonization The Journal of Organic Chemistry 2019 84 12 8019 8026 ISSN 0022 3263 doi 10 1021 acs joc 9b00870 Yang Bo Lu Zhan Visible Light Promoted Oxidative 4 2 Cycloadditions of Aryl Silyl Enol Ethers The Journal of Organic Chemistry 2016 81 16 7288 7300 ISSN 0022 3263 doi 10 1021 acs joc 6b01016 取自 https zh wikipedia org w index php title 6 溴 1 己醇 amp oldid 73549012, 维基百科，wiki，书籍，书籍，图书馆，

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