^Cashman, JR; Ghirmai, S. Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorganic & Medicinal Chemistry. 2009, 17 (19): 6890–7. PMID 19740668. doi:10.1016/j.bmc.2009.08.025.
^ 3.03.13.2Stahl, SM; Grady, MM; Moret, C; Briley, M. SNRIs: Their pharmacology, clinical efficacy, and tolerability in comparison with other classes of antidepressants. CNS Spectrums. 2005, 10 (9): 732–47. PMID 16142213.
^Morishita, Shigeru; Arita, Seizaburo. The clinical use of milnacipran for depression. European Psychiatry. 2003, 18 (1): 34–5. PMID 12648895. doi:10.1016/S0924-9338(02)00003-2.
^Hunziker, ME; Suehs, BT; Bettinger, TL; Crismon, ML. Duloxetine hydrochloride: A new dual-acting medication for the treatment of major depressive disorder. Clinical Therapeutics. 2005, 27 (8): 1126–43. PMID 16199241. doi:10.1016/j.clinthera.2005.08.010.
^Perry, R; Cassagnol, M. Desvenlafaxine: A new serotonin-norepinephrine reuptake inhibitor for the treatment of adults with major depressive disorder. Clinical Therapeutics. 2009, 31 (1): 1374–404. PMID 19698900. doi:10.1016/j.clinthera.2009.07.012.
^Luque, CA; Rey, JA. The discovery and status of sibutramine as an anti-obesity drug. European Journal of Pharmacology. 2002, 440 (2–3): 119–28. PMID 12007530. doi:10.1016/S0014-2999(02)01423-1.
行進 03, 2023
羟色胺和去甲肾上腺素再摄取抑制剂, 维基百科中的醫學内容仅供参考, 並不能視作專業意見, 如需獲取醫療幫助或意見, 请咨询专业人士, 詳見醫學聲明, 英語, snris, serotonin, norepinephrine, reuptake, inhibitors, 是一种用来治疗重度抑郁症和其他精神障碍的抗抑郁药, snri有时候也用来治疗焦虑症, 强迫症, 多动症, 慢性神经性疼痛, 躯体化障碍, 纤维肌痛综合征和缓解更年期症状, snri是高效的, 已知这些神经递质在控制情绪时发挥着重要的作用, snri比. 维基百科中的醫學内容仅供参考 並不能視作專業意見 如需獲取醫療幫助或意見 请咨询专业人士 詳見醫學聲明 5 羟色胺和去甲肾上腺素再摄取抑制剂 英語 SNRIs Serotonin norepinephrine reuptake inhibitors 是一种用来治疗重度抑郁症和其他精神障碍的抗抑郁药 SNRI有时候也用来治疗焦虑症 强迫症 多动症 慢性神经性疼痛 躯体化障碍 纤维肌痛综合征和缓解更年期症状 SNRI是高效的5 羟色胺和去甲肾上腺素再摄取抑制剂 1 已知这些神经递质在控制情绪时发挥着重要的作用 SNRI比使用更广泛但只能单独作用于5 羟色胺的选择性5 羟色胺再摄取抑制剂 SSRI 作用更多 已批准的SNRI时间线图 活性成分 药品名称 治疗用途 受体亲和力 Ki nm 结构文拉法辛 Venlafaxine 怡诺思 Efexor 重性抑郁障碍 包括对其他治疗没反应的患者 广泛性焦虑症 慢性疼痛综合症 2 5 HT 7 8 NE 1920 D 6050 3 米那普仑 Milnacipran Savella Ixel Dalcipran Toledomin 纤维肌痛综合征及其并发症 重度抑郁障碍 4 5 HT 8 4 NE 22 D gt 100000 3 度洛西汀 Duloxetine Cymbalta Ariclaim Xeristar Yentreve 重度抑郁障碍和纤维肌痛综合征 5 5 HT 0 07 NE 1 2 D 230 3 左旋米那普倫 Fetzima 成人重度抑郁障碍 5 HT NA NE NA D NA去甲文拉法辛 Desvenlafaxine Pristiq 成人重度抑郁障碍 6 5 HT 61 4 NE 2953 D NA西布曲明 Sibutramine Meridia Reductil 肥胖 7 5 HT 298 NE 5451 D 9435 HT 5 羟色胺 NE 去甲肾上腺素 D 多巴胺 NA 不可用引用 编辑 Cashman JR Ghirmai S Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi target inhibitors as potential agents for depression Bioorganic amp Medicinal Chemistry 2009 17 19 6890 7 PMID 19740668 doi 10 1016 j bmc 2009 08 025 Gutierrez MA Stimmel GL Aiso JY Venlafaxine A 2003 update Clinical Therapeutics 2003 25 8 2138 54 PMID 14512125 doi 10 1016 s0149 2918 03 80210 2 3 0 3 1 3 2 Stahl SM Grady MM Moret C Briley M SNRIs Their pharmacology clinical efficacy and tolerability in comparison with other classes of antidepressants CNS Spectrums 2005 10 9 732 47 PMID 16142213 Morishita Shigeru Arita Seizaburo The clinical use of milnacipran for depression European Psychiatry 2003 18 1 34 5 PMID 12648895 doi 10 1016 S0924 9338 02 00003 2 Hunziker ME Suehs BT Bettinger TL Crismon ML Duloxetine hydrochloride A new dual acting medication for the treatment of major depressive disorder Clinical Therapeutics 2005 27 8 1126 43 PMID 16199241 doi 10 1016 j clinthera 2005 08 010 Perry R Cassagnol M Desvenlafaxine A new serotonin norepinephrine reuptake inhibitor for the treatment of adults with major depressive disorder Clinical Therapeutics 2009 31 1 1374 404 PMID 19698900 doi 10 1016 j clinthera 2009 07 012 Luque CA Rey JA The discovery and status of sibutramine as an anti obesity drug European Journal of Pharmacology 2002 440 2 3 119 28 PMID 12007530 doi 10 1016 S0014 2999 02 01423 1 取自 https zh wikipedia org w index php title 5 羟色胺和去甲肾上腺素再摄取抑制剂 amp oldid 73770096, 维基百科，wiki，书籍，书籍，图书馆，
