1990年代,《魔鬼剋星》系列電影的編劇兼主演之一丹·艾克洛德寫了一份劇本,暫定名為《魔鬼剋星3:背水一戰》(Ghostbusters III: Hellbent)[6]。該概念是將角色轉移到平行宇宙的曼哈頓,名為Manhellton,魔鬼剋星將在這個「地獄」般的地方與魔鬼作戰[7][8]。當時,艾克洛德表示雖然演員們並非如此,但片商仍對此很感興趣。在故事中,一支年輕的新魔鬼剋星團隊現身,雷·史坦茲與溫斯頓·雷德莫爾努力維持他們的事業,而彼得·威克曼則與黛娜·巴萊特(Dana Barrett)的關係變得較為嚴肅[8];最後該片沒有了下文。這份概念在幾年後被2009年電子遊戲《魔鬼剋星(英语:Ghostbusters: The Video Game)》回收利用。
《魔鬼剋星 未來世》原定由索尼影視發行(英语:Sony Pictures Motion Picture Group)定於2020年7月10日在美國上映[36]。2020年3月,由於受2019冠狀病毒病美國疫情影響,本片延期至2021年3月5日在美國上映[47]。2020年10月,本片延期至2021年6月11日在美國上映[48]。2021年1月,本片再度延期至2021年11月11日在美國上映[49]。最終定檔於11月19日。本片於2021年8月23日登上CinemaCon(英语:National Association of Theatre Owners)舉行全球首映。[50]
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