1885年,旅日的荷兰化学家Johann Frederik Eijkman从日本莽草(シキミ,Shikimi)中提取得到莽草酸。[1]但是直到1934年,莽草酸的化学结构才由德国化学家Hermann O. L. Fischer和Gerda Dangschat阐明。[2]长期以来,莽草酸主要从八角茴香科植物八角或日本莽草(日本大茴香)等的干燥成熟果实中提取,近年来也有从北美枫香的果实以及松针中提取莽草酸的研究报道。[3][4]
生物合成编辑
註釋编辑
^The Botanical Relations of Illicium Religiosum, Sieb., Illicium Anisatum, Lour. J. F. Eykman, American Journal of Pharmacy, 1881, volume 53, Number 8 (article (页面存档备份,存于互联网档案馆))
^Konstitution der Shikimisäure. (5. Mitteilung über Chinasäure und Derivate), Helvetica Chimica Acta Volume 17, Issue 1, pages 1200–1207, 1934.(DOI:10.1002/hlca.193401701150)
^Enrich, Liza B. Liquidambar styraciflua: a renewable source of shikimic acid. Tetrahedron Letters. 2008, 49 (16): 2503–2505. doi:10.1016/j.tetlet.2008.02.140.
^Maine pine needles yield valuable Tamiflu material (页面存档备份,存于互联网档案馆), Boston.com, November 7, 2010
参考文献编辑
The shikimate pathway, E. Haslam, 2 editions - first published in 1974
Shikimic acid, E. Haslam, 1 edition - first published in 1993