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维基百科

痕量胺相关受体

一月 01, 1970

维基百科中的醫學内容仅供参考，並不能視作專業意見。如需獲取醫療幫助或意見，请咨询专业人士。詳見醫學聲明。

痕量胺相关受体（英語：Trace amine-associated receptors，简称TAAR，有时也称trace amine receptors）是一种G蛋白偶联受体，于2001年发现。[1][2][3]其中，人类身上六个功能性痕量胺相关受体中的第一个，TAAR1（英语：TAAR1），因为是痕量胺的内源受体这一独特功能而在医学界、制药研究方面备受瞩目——痕量胺是苯丙氨酸和色氨酸以及苯丙胺、甲基苯丙胺等兴奋剂的痕量代谢产物。[4][5][6][7][8][9]2004年的一份研究显示，哺乳动物的TAAR1也是甲状腺激素的脱羧碘化代谢产物。[6] 脊椎动物的TAAR2至TAAR9也可用作嗅覺受器，探测挥发性胺。[10]

参考资料 编辑

  1. ^ Hussain A, Saraiva LR, Korsching SI. Positive Darwinian selection and the birth of an olfactory receptor clade in teleosts. PNAS. 2009, 106 (11): 4313–8. PMC 2657432  . PMID 19237578. doi:10.1073/pnas.0803229106. 
  2. ^ Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C. Trace amines: identification of a family of mammalian G protein-coupled receptors. PNAS. 2001, 98 (16): 8966–71. PMC 55357  . PMID 11459929. doi:10.1073/pnas.151105198. 
  3. ^ Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, Quigley DI, Darland T, Suchland KL, Pasumamula S, Kennedy JL, Olson SB, Magenis RE, Amara SG, Grandy DK. Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol. Pharmacol. 2001, 60 (6): 1181–8. PMID 11723224. doi:10.1124/mol.60.6.1181. 
  4. ^ Miller GM. The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J. Neurochem. January 2011, 116 (2): 164–176. PMC 3005101  . PMID 21073468. doi:10.1111/j.1471-4159.2010.07109.x. 
  5. ^ Lam VM, Espinoza S, Gerasimov AS, Gainetdinov RR, Salahpour A. In-vivo pharmacology of Trace-Amine Associated Receptor 1. Eur. J. Pharmacol. June 2015, 763: 136–42. PMID 26093041. doi:10.1016/j.ejphar.2015.06.026. 
  6. ^ 6.0 6.1 Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin ET, Hatton D, Zucchi R, Grandy DK. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10 (6): 638–42. PMID 15146179. doi:10.1038/nm1051. 
  7. ^ Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol. Sci. 2005, 26 (5): 274–81. PMID 15860375. doi:10.1016/j.tips.2005.03.007. 
  8. ^ Hart ME, Suchland KL, Miyakawa M, Bunzow JR, Grandy DK, Scanlan TS. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 2006, 49 (3): 1101–12. PMID 16451074. doi:10.1021/jm0505718. 
  9. ^ Grandy DK. Trace amine-associated receptor 1-Family archetype or iconoclast?. Pharmacol. Ther. 2007, 116 (3): 355–390. PMC 2767338  . PMID 17888514. doi:10.1016/j.pharmthera.2007.06.007. 
  10. ^ Liberles SD. Trace amine-associated receptors: ligands, neural circuits, and behaviors. Curr. Opin. Neurobiol. October 2015, 34: 1–7. PMID 25616211. doi:10.1016/j.conb.2015.01.001. 

一月 01, 1970
痕量胺相关受体, 维基百科中的醫學内容仅供参考, 並不能視作專業意見, 如需獲取醫療幫助或意見, 请咨询专业人士, 詳見醫學聲明, 英語, trace, amine, associated, receptors, 简称taar, 有时也称trace, amine, receptors, 是一种g蛋白偶联受体, 于2001年发现, 其中, 人类身上六个功能性中的第一个, taar1, 英语, taar1, 因为是痕量胺的内源受体这一独特功能而在医学界, 制药研究方面备受瞩目, 痕量胺是苯丙氨酸和色氨酸以及苯丙胺, 甲. 维基百科中的醫學内容仅供参考 並不能視作專業意見 如需獲取醫療幫助或意見 请咨询专业人士 詳見醫學聲明 痕量胺相关受体 英語 Trace amine associated receptors 简称TAAR 有时也称trace amine receptors 是一种G蛋白偶联受体 于2001年发现 1 2 3 其中 人类身上六个功能性痕量胺相关受体中的第一个 TAAR1 英语 TAAR1 因为是痕量胺的内源受体这一独特功能而在医学界 制药研究方面备受瞩目 痕量胺是苯丙氨酸和色氨酸以及苯丙胺 甲基苯丙胺等兴奋剂的痕量代谢产物 4 5 6 7 8 9 2004年的一份研究显示 哺乳动物的TAAR1也是甲状腺激素的脱羧碘化代谢产物 6 脊椎动物的TAAR2至TAAR9也可用作嗅覺受器 探测挥发性胺 10 参考资料 编辑 Hussain A Saraiva LR Korsching SI Positive Darwinian selection and the birth of an olfactory receptor clade in teleosts PNAS 2009 106 11 4313 8 PMC 2657432 nbsp PMID 19237578 doi 10 1073 pnas 0803229106 Borowsky B Adham N Jones KA Raddatz R Artymyshyn R Ogozalek KL Durkin MM Lakhlani PP Bonini JA Pathirana S Boyle N Pu X Kouranova E Lichtblau H Ochoa FY Branchek TA Gerald C Trace amines identification of a family of mammalian G protein coupled receptors PNAS 2001 98 16 8966 71 PMC 55357 nbsp PMID 11459929 doi 10 1073 pnas 151105198 Bunzow JR Sonders MS Arttamangkul S Harrison LM Zhang G Quigley DI Darland T Suchland KL Pasumamula S Kennedy JL Olson SB Magenis RE Amara SG Grandy DK Amphetamine 3 4 methylenedioxymethamphetamine lysergic acid diethylamide and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor Mol Pharmacol 2001 60 6 1181 8 PMID 11723224 doi 10 1124 mol 60 6 1181 Miller GM The emerging role of trace amine associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity J Neurochem January 2011 116 2 164 176 PMC 3005101 nbsp PMID 21073468 doi 10 1111 j 1471 4159 2010 07109 x Lam VM Espinoza S Gerasimov AS Gainetdinov RR Salahpour A In vivo pharmacology of Trace Amine Associated Receptor 1 Eur J Pharmacol June 2015 763 136 42 PMID 26093041 doi 10 1016 j ejphar 2015 06 026 6 0 6 1 Scanlan TS Suchland KL Hart ME Chiellini G Huang Y Kruzich PJ Frascarelli S Crossley DA Bunzow JR Ronca Testoni S Lin ET Hatton D Zucchi R Grandy DK 3 Iodothyronamine is an endogenous and rapid acting derivative of thyroid hormone Nat Med 2004 10 6 638 42 PMID 15146179 doi 10 1038 nm1051 Lindemann L Hoener MC A renaissance in trace amines inspired by a novel GPCR family Trends Pharmacol Sci 2005 26 5 274 81 PMID 15860375 doi 10 1016 j tips 2005 03 007 Hart ME Suchland KL Miyakawa M Bunzow JR Grandy DK Scanlan TS Trace amine associated receptor agonists synthesis and evaluation of thyronamines and related analogues J Med Chem 2006 49 3 1101 12 PMID 16451074 doi 10 1021 jm0505718 Grandy DK Trace amine associated receptor 1 Family archetype or iconoclast Pharmacol Ther 2007 116 3 355 390 PMC 2767338 nbsp PMID 17888514 doi 10 1016 j pharmthera 2007 06 007 Liberles SD Trace amine associated receptors ligands neural circuits and behaviors Curr Opin Neurobiol October 2015 34 1 7 PMID 25616211 doi 10 1016 j conb 2015 01 001 取自 https zh wikipedia org w index php title 痕量胺相关受体 amp oldid 44740455, 维基百科，wiki，书籍，书籍，图书馆，

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