^Kozak, Marilyn. Initiation of Translation in prokaryotes and eukaryotes. Gene. 1999, 234: 187-208. doi:10.1016/s0378-1119(99)00210-3.
^Herzog, Etienne.; et al. Translation of the Second Gene of Peanut Clump Virus RNA 2 Occurs by Leaky Scanning In Vitro. Virology. 1995, 208: 215-225. doi:10.1006/viro.1995.1145. 引文格式1维护：显式使用等标签 (link)
^Hinnebusch, Alan. Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes. American Society for Microbiology. 2011, 75 (3): 434-467. doi:10.1128/MMBR.00008-11.
^Kozak, Marilyn. Pushing the limits of the scanning mechanism of initiation of translation. Gene. 2002, 299: 1-34. doi:10.1016/s0378-1119(02)01056-9.
^Ryaboba, Lyubov.; et al. Translation reinitiation and leaky scanning in plant viruses. Virus Research. 2006, 119: 52-62. doi:10.1016/j.virusres.2005.10.017. 引文格式1维护：显式使用等标签 (link)
^Zhou W, Song W. Leaky scanning and reinitiation regulate BACE1 gene expression.. Mol Cell Biol. 2006, 26 (9): 3353–64. PMC 1447409. PMID 16611980. doi:10.1128/MCB.26.9.3353-3364.2006.
^Kaur C, Kumar M, Patankar S. Messenger RNAs with large numbers of upstream open reading frames are translated via leaky scanning and reinitiation in the asexual stages of Plasmodium falciparum.. Parasitology. 2020, 147 (10): 1100–1113. PMID 32450933. doi:10.1017/S0031182020000840.
十二月 02, 2023
渗漏扫描, leaky, scanning, 是真核生物細胞中核糖體, 43s起始前複合物, 掃描mrna的5, 非翻译区時, 跳過前方的起始密碼子aug, 從較下游的aug開始轉譯的機制, 轉譯一般是由mrna上最靠5, 的aug開始, 但當其周圍序列配置不適合起始轉譯時, 43s起始前複合物會跳過第一個aug, 繼續往3, 掃描, 改由較下游的aug開始轉譯蛋白質, 的機制最早由美國生物學家玛丽莲, 科扎克闡明, aug密碼子在gccrccaugg, kozak序列, 其中r表示a或g, 中時最適合起始轉譯, . 渗漏扫描 Leaky scanning 是真核生物細胞中核糖體 43S起始前複合物 掃描mRNA的5 非翻译区時 跳過前方的起始密碼子AUG 從較下游的AUG開始轉譯的機制 轉譯一般是由mRNA上最靠5 的AUG開始 但當其周圍序列配置不適合起始轉譯時 43S起始前複合物會跳過第一個AUG 繼續往3 掃描 改由較下游的AUG開始轉譯蛋白質 1 2 渗漏扫描的機制最早由美國生物學家玛丽莲 科扎克闡明 AUG密碼子在GCCRCCAUGG Kozak序列 其中R表示A或G 中時最適合起始轉譯 3 當AUG周圍的序列與此不一致時 多數核糖體可能會發生滲漏掃描 即跳過該AUG 繼續往下游尋找更適宜起始轉譯的AUG 僅有少數核糖體會在該處起始轉譯 因此自可能轉譯生成數種不同的蛋白質 4 渗漏扫描發生於許多病毒的mRNA轉譯過程 5 真核細胞自身的mRNA轉譯也有此機制 6 7 參考文獻 编辑 nbsp 分子与细胞生物学主题 Kozak Marilyn Initiation of Translation in prokaryotes and eukaryotes Gene 1999 234 187 208 doi 10 1016 s0378 1119 99 00210 3 Herzog Etienne et al Translation of the Second Gene of Peanut Clump Virus RNA 2 Occurs by Leaky Scanning In Vitro Virology 1995 208 215 225 doi 10 1006 viro 1995 1145 引文格式1维护 显式使用等标签 link Hinnebusch Alan Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes American Society for Microbiology 2011 75 3 434 467 doi 10 1128 MMBR 00008 11 Kozak Marilyn Pushing the limits of the scanning mechanism of initiation of translation Gene 2002 299 1 34 doi 10 1016 s0378 1119 02 01056 9 Ryaboba Lyubov et al Translation reinitiation and leaky scanning in plant viruses Virus Research 2006 119 52 62 doi 10 1016 j virusres 2005 10 017 引文格式1维护 显式使用等标签 link Zhou W Song W Leaky scanning and reinitiation regulate BACE1 gene expression Mol Cell Biol 2006 26 9 3353 64 PMC 1447409 nbsp PMID 16611980 doi 10 1128 MCB 26 9 3353 3364 2006 Kaur C Kumar M Patankar S Messenger RNAs with large numbers of upstream open reading frames are translated via leaky scanning and reinitiation in the asexual stages of Plasmodium falciparum Parasitology 2020 147 10 1100 1113 PMID 32450933 doi 10 1017 S0031182020000840 取自 https zh wikipedia org w index php title 渗漏扫描 amp oldid 69279105, 维基百科，wiki，书籍，书籍，图书馆，
