兰尼单抗

兰尼单抗（英語：Ranibizumab，也译为雷珠单抗，商品名Lucentis）是一种单克隆抗体片段（FAB），其与贝伐单抗（bevacizumab）是从相同亲本鼠抗体获得。它比母体分子小得多，能更紧密的结合到血管内皮生长因子-A(VEGF-A)。它是一种血管生成抑制剂(angiogenesis inhibitor)，已被批准用于治疗的“湿”型老年黄斑变性。

**兰尼单抗**
单克隆抗体
种类	Fab片段（英语：Fab fragment）
目標	血管内皮生长因子A（英语：Vascular endothelial growth factor A）（VEGF-A）
臨床資料
商品名（英语：Drug nomenclature）	Lucentis, others
生物相似藥	Ranibizumab-nuna,^[1] Ranibizumab-eqrn,^[2] Byooviz,^[1]^[3] Cimerli,^[2] Ranivisio,^[4] Susvimo,^[5] Ximluci^[6]
AHFS/Drugs.com	Monograph
MedlinePlus	a607044
核准狀況	歐 EMA: yes 美 DailyMed: Ranibizumab
懷孕分級	澳: D ^[7]^[8]
给药途径	静脉注射
ATC碼	S01LA04 (WHO)
法律規範狀態
法律規範	澳：限医生处方（S4）^[7]^[8] 加：处方药（℞-only）/ Schedule D^[9] 歐：Rx-only^[11]^[3]^[4]^[6] 英：处方药（℞-only） (POM) 美：处方药（℞-only）^[10]^[1]^[5]^[2]
藥物動力學數據
生物半衰期	约9天^[10]
识别信息
CAS号	347396-82-1 ^Y
DrugBank	DB01270^Y
ChemSpider	none
UNII	ZL1R02VT79
KEGG	D05697^N
ChEMBL	ChEMBL1201825^N
化学信息
化学式	C₂₁₅₈H₃₂₈₂N₅₆₂O₆₈₁S₁₂
摩尔质量	48,379.97 g·mol⁻¹

参考资料编辑

^ ^1.0 ^1.1 ^1.2 Byooviz Nuna- ranibizumab injection, solution. DailyMed. 2022-04-27 [2022-08-02]. （原始内容于2022-08-03）.
^ ^2.0 ^2.1 ^2.2 Cimerli- ranibizumab-eqrn injection, solution. DailyMed. 2022-10-19 [2023-01-21]. （原始内容于2023-01-21）.
^ ^3.0 ^3.1 Byooviz EPAR. European Medicines Agency. 2021-06-23 [2021-09-09]. （原始内容于2021-09-10）. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
^ ^4.0 ^4.1 Ranivisio EPAR. European Medicines Agency (EMA). 2022-06-20 [2022-10-06]. （原始内容于2022-10-06）. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
^ ^5.0 ^5.1 Susvimo- ranibizumab injection, solution. DailyMed. [2021-12-19]. （原始内容于2021-12-19）.
^ ^6.0 ^6.1 Ximluci EPAR. European Medicines Agency. 2022-09-14 [2023-03-03]. （原始内容于2023-03-13）. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
^ ^7.0 ^7.1 AusPAR: Ranibizumab. Therapeutic Goods Administration (TGA). 2014-12-09 [2021-09-20]. （原始内容于2021-09-21）.
^ ^8.0 ^8.1 https://www.tga.gov.au/resources/auspmd/byooviz^{[裸露网址]}
^ Summary Basis of Decision - Byooviz. Health Canada. 2022-08-12 [2022-09-29]. （原始内容于2022-09-29）.
^ ^10.0 ^10.1 Lucentis- ranibizumab injection, solution. DailyMed. [2021-09-20]. （原始内容于2021-09-21）.
^ Lucentis EPAR. European Medicines Agency. 2018-09-17 [2021-09-09]. （原始内容于2021-09-10）. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

外部链接编辑

官方网站 Genentech

[Byooviz_FDA_label-1] 1.0 ^1.1 ^1.2 Byooviz Nuna- ranibizumab injection, solution. DailyMed. 2022-04-27 [2022-08-02]. （原始内容于2022-08-03）.

[Cimerli_FDA_label-2] 2.0 ^2.1 ^2.2 Cimerli- ranibizumab-eqrn injection, solution. DailyMed. 2022-10-19 [2023-01-21]. （原始内容于2023-01-21）.

[Byooviz_EPAR-3] 3.0 ^3.1 Byooviz EPAR. European Medicines Agency. 2021-06-23 [2021-09-09]. （原始内容于2021-09-10）. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[Ranivisio_EPAR-4] 4.0 ^4.1 Ranivisio EPAR. European Medicines Agency (EMA). 2022-06-20 [2022-10-06]. （原始内容于2022-10-06）. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[Susvimo_FDA_label-5] 5.0 ^5.1 Susvimo- ranibizumab injection, solution. DailyMed. [2021-12-19]. （原始内容于2021-12-19）.

[Ximluci_EPAR-6] 6.0 ^6.1 Ximluci EPAR. European Medicines Agency. 2022-09-14 [2023-03-03]. （原始内容于2023-03-13）. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[AusPAR:_Ranibizumab-7] 7.0 ^7.1 AusPAR: Ranibizumab. Therapeutic Goods Administration (TGA). 2014-12-09 [2021-09-20]. （原始内容于2021-09-21）.

[Byooviz_APMDS-8] 8.0 ^8.1 https://www.tga.gov.au/resources/auspmd/byooviz^{[裸露网址]}

[9] Summary Basis of Decision - Byooviz. Health Canada. 2022-08-12 [2022-09-29]. （原始内容于2022-09-29）.

[Lucentis_FDA_label-10] 10.0 ^10.1 Lucentis- ranibizumab injection, solution. DailyMed. [2021-09-20]. （原始内容于2021-09-21）.

[Lucentis_EPAR-11] Lucentis EPAR. European Medicines Agency. 2018-09-17 [2021-09-09]. （原始内容于2021-09-10）. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

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兰尼单抗

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