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维基百科

马山茶碱

马山茶碱英语:Tabernanthine)是一种在鹅花树中发现的生物碱[1]它已被用于实验室实验,以研究成瘾如何影响大脑。[2]马山茶碱可持续减少大鼠可卡因吗啡的自我给药。[3]

马山茶碱
臨床資料
ATC碼
识别信息
  • (1R,15R,17S,18S)-17-ethyl-6-methoxy-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4(9),5,7-tetraene
CAS号83-94-3
PubChem CID
  • 6326116
ChemSpider
  • 4885254
UNII
  • TV52I1S16D
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
  • DTXSID50878514
化学信息
化学式C20H26N2O
摩尔质量310.44 g·mol−1
3D模型(JSmol英语JSmol
  • 交互式图像
  • CCC1CC2CC3C1N(C2)CCC4=C3NC5=C4C=CC(=C5)OC
  • InChI=1S/C20H26N2O/c1-3-13-8-12-9-17-19-16(6-7-22(11-12)20(13)17)15-5-4-14(23-2)10-18(15)21-19/h4-5,10,12-13,17,20-21H,3,6-9,11H2,1-2H3/t12-,13+,17+,20+/m1/s1
  • Key:UCIDWKVIQZIKEK-CFDPKNGZSA-N

药理学 编辑

它是κ-阿片激动剂(Ki=0.15μM)和NMDA受体(Ki=10.5μM)拮抗剂[4][5]与伊波加因相比,它与σ1和σ2受体的结合较弱。[5]

参见 编辑

  • 冠狗牙花定碱
  • 依波加明
  • 伏康京碱
  • 山辣椒碱
  • Tabernanthalog

参考资料 编辑

  1. ^ Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine. Journal of the American Chemical Society. 1958, 80: 126–136. doi:10.1021/ja01534a036. 
  2. ^ Levi MS, Borne RF. A review of chemical agents in the pharmacotherapy of addiction. Curr. Med. Chem. October 2002, 9 (20): 1807–18. PMID 12369879. doi:10.2174/0929867023368980. 
  3. ^ Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW J, Carlson JN. Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.. Brain Res. September 1994, 657 (1–2): 14–22. PMID 7820611. S2CID 1940631. doi:10.1016/0006-8993(94)90948-2.  温哥华格式错误 (帮助)
  4. ^ Deecher DC, Teitler M, Soderlund DM, Bornmann WG, Kuehne ME, Glick SD. Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies. Brain Research. February 1992, 571 (2): 242–7. PMID 1377086. S2CID 17159661. doi:10.1016/0006-8993(92)90661-r. 
  5. ^ 5.0 5.1 Christophe Wiart. Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases. Academic Press. 16 December 2013: 67–69, 73. ISBN 978-0-12-398383-1. 

马山茶碱, 英语, tabernanthine, 是一种在鹅花树中发现的生物碱, 它已被用于实验室实验, 以研究成瘾如何影响大脑, 可持续减少大鼠可卡因和吗啡的自我给药, 臨床資料atc碼无识别信息iupac命名法, ethyl, methoxy, diazapentacyclo, nonadeca, tetraenecas号83, 3pubchem, cid6326116chemspider4885254uniitv52i1s16dcomptox, dashboard, 英语, comptox, chemical. 马山茶碱 英语 Tabernanthine 是一种在鹅花树中发现的生物碱 1 它已被用于实验室实验 以研究成瘾如何影响大脑 2 马山茶碱可持续减少大鼠可卡因和吗啡的自我给药 3 马山茶碱臨床資料ATC碼无识别信息IUPAC命名法 1R 15R 17S 18S 17 ethyl 6 methoxy 3 13 diazapentacyclo 13 3 1 02 10 04 9 013 18 nonadeca 2 10 4 9 5 7 tetraeneCAS号83 94 3PubChem CID6326116ChemSpider4885254UNIITV52I1S16DCompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID50878514化学信息化学式C 20H 26N 2O摩尔质量310 44 g mol 13D模型 JSmol 英语 JSmol 交互式图像SMILES CCC1CC2CC3C1N C2 CCC4 C3NC5 C4C CC C5 OCInChI InChI 1S C20H26N2O c1 3 13 8 12 9 17 19 16 6 7 22 11 12 20 13 17 15 5 4 14 23 2 10 18 15 21 19 h4 5 10 12 13 17 20 21H 3 6 9 11H2 1 2H3 t12 13 17 20 m1 s1Key UCIDWKVIQZIKEK CFDPKNGZSA N药理学 编辑它是k 阿片激动剂 Ki 0 15mM 和NMDA受体 Ki 10 5mM 拮抗剂 4 5 与伊波加因相比 它与s1和s2受体的结合较弱 5 参见 编辑冠狗牙花定碱 依波加明 伏康京碱 山辣椒碱 Tabernanthalog参考资料 编辑 Bartlett M F Dickel D F Taylor W I The Alkaloids of Tabernanthe iboga Part IV 1 The Structures of Ibogamine Ibogaine Tabernanthine and Voacangine Journal of the American Chemical Society 1958 80 126 136 doi 10 1021 ja01534a036 Levi MS Borne RF A review of chemical agents in the pharmacotherapy of addiction Curr Med Chem October 2002 9 20 1807 18 PMID 12369879 doi 10 2174 0929867023368980 Glick SD Kuehne ME Raucci J Wilson TE Larson D Keller RW J Carlson JN Effects of iboga alkaloids on morphine and cocaine self administration in rats relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum Brain Res September 1994 657 1 2 14 22 PMID 7820611 S2CID 1940631 doi 10 1016 0006 8993 94 90948 2 温哥华格式错误 帮助 Deecher DC Teitler M Soderlund DM Bornmann WG Kuehne ME Glick SD Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies Brain Research February 1992 571 2 242 7 PMID 1377086 S2CID 17159661 doi 10 1016 0006 8993 92 90661 r 5 0 5 1 Christophe Wiart Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases Academic Press 16 December 2013 67 69 73 ISBN 978 0 12 398383 1 取自 https zh wikipedia org w index php title 马山茶碱 amp oldid 75832757, 维基百科,wiki,书籍,书籍,图书馆,

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