石胆酸已证明对实验动物和人类具有致癌性[2]。初步的 in vitro 实验发现石胆酸可以选择性的杀死成神经细胞瘤（英语：neuroblastoma）细胞，同时保留正常的神经元细胞，并且在生理相关浓度下对许多其他恶性细胞类型具有细胞毒性[3]。
参考文献
^Lithocholic acid （页面存档备份，存于互联网档案馆） at Sigma-Aldrich
^Kozoni, V.; Tsioulias, G; Shiff, S; Rigas, B. The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: Differential effect on apoptosis in the presence of a colon carcinogen. Carcinogenesis. 2000, 21 (5): 999–1005. PMID 10783324. doi:10.1093/carcin/21.5.999.
^Goldberg, AA; Beach, A; Davies, GF; Harkness, TA; Leblanc, A; Titorenko, VI. Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget. 2011, 2 (10): 761–82. PMC 3248158. PMID 21992775. doi:10.18632/oncotarget.338.
延伸阅读
Goldberg, AA; Richard, VR; Kyryakov, P; Bourque, SD; Beach, A; Burstein, MT; Glebov, A; Koupaki, O; et al. Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. Aging. 2010, 2 (7): 393–414. PMC 2933888. PMID 20622262.
Template:Vitamin D receptor modulators
四月 01, 2023
石胆酸, 英語, lithocholic, acid, 也被称为3α, 羟基, 胆烷, 羧酸, hydroxy, cholan, acid, 缩写lca, 是一种胆汁酸, 可作为溶解剂促进脂肪的吸收, 结肠中的主要来自鹅去氧胆酸, 由肠道细菌的酶将其甾体骨架b环上的7α, 羟基还原而来, iupac名, hydroxy, dimethyl, tetradecahydro, cyclopenta, phenanthren, pentanoic, acid别名, lithocholate, lithocolic, ac. 石胆酸 英語 Lithocholic acid 也被称为3a 羟基 5b 胆烷 24 羧酸 3a hydroxy 5b cholan 24 oic acid 缩写LCA 是一种胆汁酸 可作为溶解剂促进脂肪的吸收 结肠中的石胆酸主要来自鹅去氧胆酸 由肠道细菌的酶将其甾体骨架B环上的7a 羟基还原而来 石胆酸 1 IUPAC名 4R 4 3R 5R 8R 9S 10S 13R 14S 17R 3 Hydroxy 10 13 dimethyl 2 3 4 5 6 7 8 9 11 12 14 15 16 17 tetradecahydro 1H cyclopenta a phenanthren 17 yl pentanoic acid别名 Lithocholate Lithocolic acid 3a Hydroxy 5b cholan 24 oic acid 3a Hydroxy 5b cholanic acid 5b Cholan 24 oic acid 3a ol识别CAS号 434 13 9 PubChem 9903ChemSpider 9519SMILES O C O CC C H C H 1CC C H 2 C 1 C CC C H 4 C H 2CC C H 3C C H O CC C 34C CInChI 1 C24H40O3 c1 15 4 9 22 26 27 19 7 8 20 18 6 5 16 14 17 25 10 12 23 16 2 21 18 11 13 24 19 20 3 h15 21 25H 4 14H2 1 3H3 H 26 27 t15 16 17 18 19 20 21 23 24 m1 s1InChIKey SMEROWZSTRWXGI HVATVPOCBIEINECS 207 099 1ChEBI 16325RTECS FZ2275000IUPHAR配体 611性质化学式 C24H40O3摩尔质量 376 57 g mol g mol 熔点 183 188 C 268 K 危险性安全术语 S S22 S24 25若非注明 所有数据均出自标准状态 25 100 kPa 下 石胆酸已证明对实验动物和人类具有致癌性 2 初步的 in vitro 实验发现石胆酸可以选择性的杀死成神经细胞瘤 英语 neuroblastoma 细胞 同时保留正常的神经元细胞 并且在生理相关浓度下对许多其他恶性细胞类型具有细胞毒性 3 参考文献 编辑 Lithocholic acid 页面存档备份 存于互联网档案馆 at Sigma Aldrich Kozoni V Tsioulias G Shiff S Rigas B The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis Differential effect on apoptosis in the presence of a colon carcinogen Carcinogenesis 2000 21 5 999 1005 PMID 10783324 doi 10 1093 carcin 21 5 999 Goldberg AA Beach A Davies GF Harkness TA Leblanc A Titorenko VI Lithocholic bile acid selectively kills neuroblastoma cells while sparing normal neuronal cells Oncotarget 2011 2 10 761 82 PMC 3248158 PMID 21992775 doi 10 18632 oncotarget 338 延伸阅读 编辑Goldberg AA Richard VR Kyryakov P Bourque SD Beach A Burstein MT Glebov A Koupaki O et al Chemical genetic screen identifies lithocholic acid as an anti aging compound that extends yeast chronological life span in a TOR independent manner by modulating housekeeping longevity assurance processes Aging 2010 2 7 393 414 PMC 2933888 PMID 20622262 Template Vitamin D receptor modulators 取自 https zh wikipedia org w index php title 石胆酸 amp oldid 69997316, 维基百科，wiki，书籍，书籍，图书馆，
