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维基百科

使君子氨酸

十月 04, 2023

使君子氨酸（英語：Quisqualic acid）是一种AMPA受体、红藻氨酸受体和I型代谢型谷氨酸受体的激动剂，也是已知最强的AMPA受体激动剂[1][2][3][4]。由于它具有兴奋毒性，被广泛用于神经科学研究中，选择性地破坏大脑中的神经元或脊髓[5][6][7]。使君子氨酸存在于使君子科物种的种子中。 一项由美国农业部进行的研究显示，使君子氨酸也存在于天竺葵属的花瓣中，并能使其天敌甲壳虫神经系统瘫痪[8][9]。其作用机理为，使君子氨酸可被视为L-谷氨酸的类似物，可以作为昆虫神经肌肉结和哺乳动物中枢神经系统的神经递质。[10]

使君子氨酸
IUPAC名
(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
识别
CAS号 52809-07-1  N
PubChem 40539
ChemSpider 37038
SMILES
 
  • O=C1NC(=O)ON1C[C@H](N)C(=O)O
InChI
 
  • 1/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
InChIKey ASNFTDCKZKHJSW-REOHCLBHBE
DrugBank DB02999
KEGG C08296
MeSH Quisqualic+Acid
IUPHAR配体 1372
性质
化学式 C5H7N3O5
摩尔质量 189.126 g/mol g·mol⁻¹
熔点 187 - 188 °C（272 K）
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。
维基百科中的醫學内容仅供参考，並不能視作專業意見。如需獲取醫療幫助或意見，请咨询专业人士。詳見醫學聲明。

另见 编辑

参考文献 编辑

  1. ^ Jin R, Horning M, Mayer ML, Gouaux E. Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate. Biochemistry. 2002 Dec 31;41(52):15635-43. PMID 12501192
  2. ^ Kuang D, Hampson DR. Ion dependence of ligand binding to metabotropic glutamate receptors. Biochemical and Biophysical Research Communications. 2006 Jun 23;345(1):1-6. PMID 16674916
  3. ^ Zhang W, Robert A, Vogensen SB, Howe JR. The relationship between agonist potency and AMPA receptor kinetics. Biophysical Journal. 2006 Aug 15;91(4):1336-46. PMID 16731549
  4. ^ Bentham Science Publishers. Current Pharmaceutical Design. Bentham Science Publishers. August 1996: 399– [2018-09-07]. （原始内容于2019-03-13）. 
  5. ^ Muir JL, Page KJ, Sirinathsinghji DJ, Robbins TW, Everitt BJ. Excitotoxic lesions of basal forebrain cholinergic neurons: effects on learning, memory and attention. Behavioural Brain Research. 1993 Nov 30;57(2):123-31. PMID 7509608
  6. ^ Giovannelli L, Casamenti F, Pepeu G. C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals. Journal of Neural Transmission. 1998;105(8-9):935-48. PMID 9869327
  7. ^ Lee JW, Furmanski O, Castellanos DA, Daniels LA, Hama AT, Sagen J. Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury. Neuroscience Letters. 2008 Jul 11;439(2):212-5. PMID 18524486
  8. ^ Geraniums and Begonias: New Research on Old Garden Favorites （页面存档备份，存于互联网档案馆） (the March 2010 issue of Agricultural Research magazine.)
  9. ^ Ranger, C.M., Winter, R. E., Singh, A. P., Reding, M. E., Frantz, J. M., Locke, J. C., and Krause, C. R. 2011. Rare excitatory amino acid from flowers of zonal geranium responsible for paralyzing the Japanese beetle. Proceedings of the National Academy of Sciences. http://www.pnas.org/content/early/2010/12/29/1013497108.full.pdf+html
  10. ^ Usherwood, P. N. R. 1994. Insect glutamate receptors. Advances in Insect Biochemistry and Physiology. 24: 309-341.

十月 04, 2023
使君子氨酸, 英語, quisqualic, acid, 是一种ampa受体, 红藻氨酸受体和i型代谢型谷氨酸受体的激动剂, 也是已知最强的ampa受体激动剂, 由于它具有兴奋毒性, 被广泛用于神经科学研究中, 选择性地破坏大脑中的神经元或脊髓, 存在于使君子科物种的种子中, 一项由美国农业部进行的研究显示, 也存在于天竺葵属的花瓣中, 并能使其天敌甲壳虫神经系统瘫痪, 其作用机理为, 可被视为l, 谷氨酸的类似物, 可以作为昆虫神经肌肉结和哺乳动物中枢神经系统的神经递质, iupac名, amino, dioxo. 使君子氨酸 英語 Quisqualic acid 是一种AMPA受体 红藻氨酸受体和I型代谢型谷氨酸受体的激动剂 也是已知最强的AMPA受体激动剂 1 2 3 4 由于它具有兴奋毒性 被广泛用于神经科学研究中 选择性地破坏大脑中的神经元或脊髓 5 6 7 使君子氨酸存在于使君子科物种的种子中 一项由美国农业部进行的研究显示 使君子氨酸也存在于天竺葵属的花瓣中 并能使其天敌甲壳虫神经系统瘫痪 8 9 其作用机理为 使君子氨酸可被视为L 谷氨酸的类似物 可以作为昆虫神经肌肉结和哺乳动物中枢神经系统的神经递质 10 使君子氨酸IUPAC名 2S 2 amino 3 3 5 dioxo 1 2 4 wbr oxadiazolidin 2 yl propanoic acid识别CAS号 52809 07 1 NPubChem 40539ChemSpider 37038SMILES O C1NC O ON1C C H N C O OInChI 1 C5H7N3O5 c6 2 3 9 10 1 8 4 11 7 5 12 13 8 h2H 1 6H2 H 9 10 H 7 11 12 t2 m0 s1InChIKey ASNFTDCKZKHJSW REOHCLBHBEDrugBank DB02999KEGG C08296MeSH Quisqualic AcidIUPHAR配体 1372性质化学式 C5H7N3O5摩尔质量 189 126 g mol g mol 熔点 187 188 C 272 K 若非注明 所有数据均出自标准状态 25 100 kPa 下 维基百科中的醫學内容仅供参考 並不能視作專業意見 如需獲取醫療幫助或意見 请咨询专业人士 詳見醫學聲明 另见 编辑奎可拉明 非蛋白质氨基酸参考文献 编辑 Jin R Horning M Mayer ML Gouaux E Mechanism of activation and selectivity in a ligand gated ion channel structural and functional studies of GluR2 and quisqualate Biochemistry 2002 Dec 31 41 52 15635 43 PMID 12501192 Kuang D Hampson DR Ion dependence of ligand binding to metabotropic glutamate receptors Biochemical and Biophysical Research Communications 2006 Jun 23 345 1 1 6 PMID 16674916 Zhang W Robert A Vogensen SB Howe JR The relationship between agonist potency and AMPA receptor kinetics Biophysical Journal 2006 Aug 15 91 4 1336 46 PMID 16731549 Bentham Science Publishers Current Pharmaceutical Design Bentham Science Publishers August 1996 399 2018 09 07 原始内容存档于2019 03 13 Muir JL Page KJ Sirinathsinghji DJ Robbins TW Everitt BJ Excitotoxic lesions of basal forebrain cholinergic neurons effects on learning memory and attention Behavioural Brain Research 1993 Nov 30 57 2 123 31 PMID 7509608 Giovannelli L Casamenti F Pepeu G C fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid a study in adult and aged animals Journal of Neural Transmission 1998 105 8 9 935 48 PMID 9869327 Lee JW Furmanski O Castellanos DA Daniels LA Hama AT Sagen J Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury Neuroscience Letters 2008 Jul 11 439 2 212 5 PMID 18524486 Geraniums and Begonias New Research on Old Garden Favorites 页面存档备份 存于互联网档案馆 the March 2010 issue of Agricultural Research magazine Ranger C M Winter R E Singh A P Reding M E Frantz J M Locke J C and Krause C R 2011 Rare excitatory amino acid from flowers of zonal geranium responsible for paralyzing the Japanese beetle Proceedings of the National Academy of Sciences http www pnas org content early 2010 12 29 1013497108 full pdf html Usherwood P N R 1994 Insect glutamate receptors Advances in Insect Biochemistry and Physiology 24 309 341 取自 https zh wikipedia org w index php title 使君子氨酸 amp oldid 77182224, 维基百科，wiki，书籍，书籍，图书馆，

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