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维基百科

丹皮酚

四月 11, 2024

丹皮酚（paeonol）是在芍药属[2]植物（如牡丹）、 [3]一把伞南星[4]和日本薯蓣中发现的一种酚类化合物。[5]它是某些中药中的成分。[6]

丹皮酚
IUPAC名
1-(2-Hydroxy-4-methoxyphenyl)ethanone
识别
CAS号 552-41-0 [1]
PubChem 11092
ChemSpider 10621
SMILES
 
  • CC(=O)C1=C(C=C(C=C1)OC)O
InChI
 
  • 1/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3
InChIKey UILPJVPSNHJFIK-UHFFFAOYAG
性质
化学式 C9H10O3
摩尔质量 166.17 g·mol−1
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

生物学作用 编辑

已经观察到丹皮酚在体外或动物模型中的许多生物学作用。丹皮酚可提高阿尔茨海默病大鼠模型的皮质细胞色素氧化酶和血管肌动蛋白水平，并改善其行为。[7]

丹皮酚具有抗突变活性。[3][5]它还在卡拉胶引起的痛觉过敏中具有抗炎和镇痛作用。[8]丹皮酚可通过调节组胺和TNF-α抑制过敏反应。[9]

金属配合物 编辑

丹皮酚的金属配合物分别在不存在和存在吡啶溶剂的情况下表现出四面体和八面体的几何配形。[10]

参考资料 编辑

  1. ^ CAS # 552-41-0, Paeonol, 2'-Hydroxy-4'-methoxyacetophenone, 1-(2-hydroxy-4-methoxyphenyl)ethan-1-one. [2020-07-17]. （原始内容于2020-08-11）. 
  2. ^ Zhang, L., Li, D. C., & Liu, L. F. (2019). Paeonol: pharmacological effects and mechanisms of action. International immunopharmacology, 72, 413-421. PMID 31030097 doi:10.1016/j.intimp.2019.04.033
  3. ^ 3.0 3.1 Paeonol: a bio-antimutagen isolated from a crude drug, moutan cortex. Agricultural and Biological Chemistry. 1987, 51 (5): 1441–1442. doi:10.1271/bbb1961.51.1441. INIST（法语：Institut de l'information scientifique et technique）:7609719. 
  4. ^ Isolation of paeonol from Arisaema erubescens. Planta Medica. 1995, 61 (6): 586–587. PMID 8824957. doi:10.1055/s-2006-959390. INIST（法语：Institut de l'information scientifique et technique）:2920867. 
  5. ^ 5.0 5.1 Miyazawa, Mitsuo; Shimamura, Hideo; Nakamura, Sei-Ichi; Kameoka, Hiromu. Antimutagenic Activity of (+)-β-Eudesmol and Paeonol fromDioscorea japonica. Journal of Agricultural and Food Chemistry. 1996, 44 (7): 1647–1650. doi:10.1021/jf950792u. 
  6. ^ Deng, Chunhui; Yao, Ning; Wang, Ben; Zhang, Xiangmin. Development of microwave-assisted extraction followed by headspace single-drop microextraction for fast determination of paeonol in traditional Chinese medicines. Journal of Chromatography A. 2006, 1103 (1): 15–21. PMID 16309693. doi:10.1016/j.chroma.2005.11.023. 
  7. ^ Zhou, Jun; Zhou, Li; Hou, Deren; Tang, Jiaochun; Sun, Juanjuan; Bondy, Stephen C. Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease (PDF). Brain Research. 2011, 1388: 141–7 [2020-07-17]. PMID 21377451. doi:10.1016/j.brainres.2011.02.064. （原始内容 (PDF)于2018-07-24）. 
  8. ^ Chou, Tz-Chong. Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. British Journal of Pharmacology. 2003, 139 (6): 1146–52. PMC 1573952  . PMID 12871833. doi:10.1038/sj.bjp.0705360. 
  9. ^ Kim, Sung Hoon; Kim, Seung-Ae; Park, Mi-Kyung; Kim, Seung-Hyung; Park, Young-Doo; Na, Ho-Jeong; Kim, Hyung-Min; Shin, Min-Kyu; Ahn, Kyoo-Seok. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α. International Immunopharmacology. 2004, 4 (2): 279–87. PMID 14996419. doi:10.1016/j.intimp.2003.12.013. 
  10. ^ Patel, Mahesh kumar. Solvent effect on neutral Co(II) complexes of paeonol derivative equalitative and quantitative studies from energy frame work and Hirshfeld surface analysis. Journal of Molecular Structure. 2019, 1196: 119–131. Bibcode:2019JMoSt1196..119P. doi:10.1016/j.molstruc.2019.06.050. 

四月 11, 2024
丹皮酚, paeonol, 是在芍药属, 植物, 如牡丹, 一把伞南星, 和日本薯蓣中发现的一种酚类化合物, 它是某些中药中的成分, iupac名1, hydroxy, methoxyphenyl, ethanone识别cas号, pubchem, 11092chemspider, 10621smiles, oinchi, c9h10o3, 2h3inchikey, uilpjvpsnhjfik, uhfffaoyag性质化学式, c9h10o3摩尔质量, 1若非注明, 所有数据均出自标准状态, 生物学作用, 编辑. 丹皮酚 paeonol 是在芍药属 2 植物 如牡丹 3 一把伞南星 4 和日本薯蓣中发现的一种酚类化合物 5 它是某些中药中的成分 6 丹皮酚IUPAC名1 2 Hydroxy 4 methoxyphenyl ethanone识别CAS号 552 41 0 1 PubChem 11092ChemSpider 10621SMILES CC O C1 C C C C C1 OC OInChI 1 C9H10O3 c1 6 10 8 4 3 7 12 2 5 9 8 11 h3 5 11H 1 2H3InChIKey UILPJVPSNHJFIK UHFFFAOYAG性质化学式 C9H10O3摩尔质量 166 17 g mol 1若非注明 所有数据均出自标准状态 25 100 kPa 下 生物学作用 编辑已经观察到丹皮酚在体外或动物模型中的许多生物学作用 丹皮酚可提高阿尔茨海默病大鼠模型的皮质细胞色素氧化酶和血管肌动蛋白水平 并改善其行为 7 丹皮酚具有抗突变活性 3 5 它还在卡拉胶引起的痛觉过敏中具有抗炎和镇痛作用 8 丹皮酚可通过调节组胺和TNF a抑制过敏反应 9 金属配合物 编辑丹皮酚的金属配合物分别在不存在和存在吡啶溶剂的情况下表现出四面体和八面体的几何配形 10 参考资料 编辑 CAS 552 41 0 Paeonol 2 Hydroxy 4 methoxyacetophenone 1 2 hydroxy 4 methoxyphenyl ethan 1 one 2020 07 17 原始内容存档于2020 08 11 Zhang L Li D C amp Liu L F 2019 Paeonol pharmacological effects and mechanisms of action International immunopharmacology 72 413 421 PMID 31030097 doi 10 1016 j intimp 2019 04 033 3 0 3 1 Paeonol a bio antimutagen isolated from a crude drug moutan cortex Agricultural and Biological Chemistry 1987 51 5 1441 1442 doi 10 1271 bbb1961 51 1441 INIST 法语 Institut de l information scientifique et technique 7609719 Isolation of paeonol from Arisaema erubescens Planta Medica 1995 61 6 586 587 PMID 8824957 doi 10 1055 s 2006 959390 INIST 法语 Institut de l information scientifique et technique 2920867 5 0 5 1 Miyazawa Mitsuo Shimamura Hideo Nakamura Sei Ichi Kameoka Hiromu Antimutagenic Activity of b Eudesmol and Paeonol fromDioscorea japonica Journal of Agricultural and Food Chemistry 1996 44 7 1647 1650 doi 10 1021 jf950792u Deng Chunhui Yao Ning Wang Ben Zhang Xiangmin Development of microwave assisted extraction followed by headspace single drop microextraction for fast determination of paeonol in traditional Chinese medicines Journal of Chromatography A 2006 1103 1 15 21 PMID 16309693 doi 10 1016 j chroma 2005 11 023 Zhou Jun Zhou Li Hou Deren Tang Jiaochun Sun Juanjuan Bondy Stephen C Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer s disease PDF Brain Research 2011 1388 141 7 2020 07 17 PMID 21377451 doi 10 1016 j brainres 2011 02 064 原始内容存档 PDF 于2018 07 24 Chou Tz Chong Anti inflammatory and analgesic effects of paeonol in carrageenan evoked thermal hyperalgesia British Journal of Pharmacology 2003 139 6 1146 52 PMC 1573952 nbsp PMID 12871833 doi 10 1038 sj bjp 0705360 Kim Sung Hoon Kim Seung Ae Park Mi Kyung Kim Seung Hyung Park Young Doo Na Ho Jeong Kim Hyung Min Shin Min Kyu Ahn Kyoo Seok Paeonol inhibits anaphylactic reaction by regulating histamine and TNF a International Immunopharmacology 2004 4 2 279 87 PMID 14996419 doi 10 1016 j intimp 2003 12 013 Patel Mahesh kumar Solvent effect on neutral Co II complexes of paeonol derivative equalitative and quantitative studies from energy frame work and Hirshfeld surface analysis Journal of Molecular Structure 2019 1196 119 131 Bibcode 2019JMoSt1196 119P doi 10 1016 j molstruc 2019 06 050 取自 https zh wikipedia org w index php title 丹皮酚 amp oldid 81678862, 维基百科，wiki，书籍，书籍，图书馆，

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