SOS反应（SOS response）也称应急反应，是对DNA损伤的整体反应，其中细胞周期被阻止，DNA修复和诱变（英语：Mutagenesis）被诱导。该系统涉及 RecA（英语：RecA） 蛋白（真核生物中的RAD51）。 RecA 蛋白受单链DNA刺激，参与SOS反应基因阻遏蛋白 (LexA（英语：LexA）) 的失活，从而诱导反应。它是一种容易出错的修复系统，对在广泛的物种中观察到的 DNA 变化有重大贡献。
E. coli SOS System: DNA can be damaged by cross-linking agents, UV irradiation, alkylating agents, etc. Once damaged, RecA, a LexA protease, senses that damaged DNA and becomes activated by removing its repressor. Once the LexA dimer repressor is removed, the expression of LexA operon is autoregulatory. In addition to being a LexA protease, the RecA protein also catalyzes a few novel DNA reactions such as annealing of single-stranded DNA and transfer of strands. The SOS system has enhanced DNA-repair capacity, including excision and post-replication repair, enhanced mutagenesis, prophage induction. The system can also inhibit cell division and cell respiration.[1]
The SOS response has been proposed as a model for bacterial evolution of certain types of antibiotic resistance.[2]
发现
由克罗地亚生物学家 Miroslav Radman[3] 在1975年发现和命名，是指染色体DNA受到严重损伤时细胞做出的应激反应。在这种情况下，多种基因被诱导表达，其中1个拷贝的UmuC和2个拷贝的被截短的UmuD主要组成DNA聚合酶Ⅴ，后者可在DNA模板有切口的区域催化DNA复制。
^Little JW, Mount DW. The SOS regulatory system of Escherichia coli. Cell. May 1982, 29 (1): 11–22. PMID 7049397. doi:10.1016/0092-8674(82)90085-X.
^Michel B. After 30 years of study, the bacterial SOS response still surprises us. PLOS Biology. July 2005, 3 (7): e255. PMC 1174825. PMID 16000023. doi:10.1371/journal.pbio.0030255.
^Radman, M. Phenomenology of an inducible mutagenic DNA repair pathway in Escherichia coli: SOS repair hypothesis. Basic Life Sciences. 1975, 5A: 355–367. PMID 1103845.
sos反应, response, 也称应急反应, 是对dna损伤的整体反应, 其中细胞周期被阻止, dna修复和诱变, 英语, mutagenesis, 被诱导, 该系统涉及, reca, 英语, reca, 蛋白, 真核生物中的rad51, reca, 蛋白受单链dna刺激, 参与基因阻遏蛋白, lexa, 英语, lexa, 的失活, 从而诱导反应, 它是一种容易出错的修复系统, 对在广泛的物种中观察到的, 变化有重大贡献, coli, system, damaged, cross, linking, agen. SOS反应 SOS response 也称应急反应 是对DNA损伤的整体反应 其中细胞周期被阻止 DNA修复和诱变 英语 Mutagenesis 被诱导 该系统涉及 RecA 英语 RecA 蛋白 真核生物中的RAD51 RecA 蛋白受单链DNA刺激 参与SOS反应基因阻遏蛋白 LexA 英语 LexA 的失活 从而诱导反应 它是一种容易出错的修复系统 对在广泛的物种中观察到的 DNA 变化有重大贡献 E coli SOS System DNA can be damaged by cross linking agents UV irradiation alkylating agents etc Once damaged RecA a LexA protease senses that damaged DNA and becomes activated by removing its repressor Once the LexA dimer repressor is removed the expression of LexA operon is autoregulatory In addition to being a LexA protease the RecA protein also catalyzes a few novel DNA reactions such as annealing of single stranded DNA and transfer of strands The SOS system has enhanced DNA repair capacity including excision and post replication repair enhanced mutagenesis prophage induction The system can also inhibit cell division and cell respiration 1 The SOS response has been proposed as a model for bacterial evolution of certain types of antibiotic resistance 2 发现 编辑由克罗地亚生物学家 Miroslav Radman 3 在1975年发现和命名 是指染色体DNA受到严重损伤时细胞做出的应激反应 在这种情况下 多种基因被诱导表达 其中1个拷贝的UmuC和2个拷贝的被截短的UmuD主要组成DNA聚合酶 后者可在DNA模板有切口的区域催化DNA复制 参见 编辑DNA修复参考资料 编辑 Little JW Mount DW The SOS regulatory system of Escherichia coli Cell May 1982 29 1 11 22 PMID 7049397 doi 10 1016 0092 8674 82 90085 X Michel B After 30 years of study the bacterial SOS response still surprises us PLOS Biology July 2005 3 7 e255 PMC 1174825 PMID 16000023 doi 10 1371 journal pbio 0030255 Radman M Phenomenology of an inducible mutagenic DNA repair pathway in Escherichia coli SOS repair hypothesis Basic Life Sciences 1975 5A 355 367 PMID 1103845 这是一篇與生物学相關的小作品 你可以通过编辑或修订扩充其内容 查论编 取自 https zh wikipedia org w index php title SOS反应 amp oldid 75221780, 维基百科，wiki，书籍，书籍，图书馆，
