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维基百科

MK-608

十月 06, 2023

MK-608是一种抗病毒药物，属于腺苷类似物（一种核苷类似物（英语：nucleoside analog））。它最初由默克公司开发，用于治疗丙型肝炎。虽然它在动物研究中取得了较好的结果，[1][2]但最终在临床试验中失败。[3]后来，它被广泛用于体外及动物的抗病毒研究，并显示出对一系列病毒的活性，如骨痛熱症、[4]蜱传脑炎病毒（英语：tick-borne encephalitis virus）、[5]脊髓灰質炎病毒、[6][7]以及茲卡病毒。[8][9]

MK-608
臨床資料
其他名稱7-Deaza-2’-C-methyladenosine; 7DMA
法律規範狀態
法律規範
  • 美：Investigational New Drug
识别信息
  • (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
CAS号443642-29-3  
PubChem CID
  • 3011893
ChemSpider
  • 2280834
UNII
  • QRR62J6WEF
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
  • DTXSID60963208
化学信息
化学式C12H16N4O4
摩尔质量280.28 g·mol−1
3D模型（JSmol（英语：JSmol））
  • 交互式图像
  • C[C@]1([C@@H]([C@H](O[C@H]1n2ccc3c2ncnc3N)CO)O)O
  • InChI=1S/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/m1/s1
  • Key:IRZRJANZDIOOIF-GAJNKVMBSA-N

参考文献 编辑

  1. ^ Carroll SS, Ludmerer S, Handt L, Koeplinger K, Zhang NR, Graham D, et al. Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees. Antimicrobial Agents and Chemotherapy. March 2009, 53 (3): 926–34. PMC 2650549  . PMID 19075052. doi:10.1128/AAC.01032-08. 
  2. ^ Olsen DB, Davies ME, Handt L, Koeplinger K, Zhang NR, Ludmerer SW, et al. Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents. Antimicrobial Agents and Chemotherapy. February 2011, 55 (2): 937–9. PMC 3028818  . PMID 21115793. doi:10.1128/AAC.00990-10. 
  3. ^ Arnold JJ, Sharma SD, Feng JY, Ray AS, Smidansky ED, Kireeva ML, et al. Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides. PLOS Pathogens. 2012, 8 (11): e1003030. PMC 3499576  . PMID 23166498. doi:10.1371/journal.ppat.1003030. 
  4. ^ Schul W, Liu W, Xu HY, Flamand M, Vasudevan SG. A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. The Journal of Infectious Diseases. March 2007, 195 (5): 665–74. PMID 17262707. doi:10.1086/511310  . 
  5. ^ Eyer L, Valdés JJ, Gil VA, Nencka R, Hřebabecký H, Šála M, et al. Nucleoside inhibitors of tick-borne encephalitis virus. Antimicrobial Agents and Chemotherapy. September 2015, 59 (9): 5483–93. PMC 4538560  . PMID 26124166. doi:10.1128/AAC.00807-15. 
  6. ^ Goris N, De Palma A, Toussaint JF, Musch I, Neyts J, De Clercq K. 2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus. Antiviral Research. March 2007, 73 (3): 161–8. PMID 17055073. doi:10.1016/j.antiviral.2006.09.007. 
  7. ^ Wu R, Smidansky ED, Oh HS, Takhampunya R, Padmanabhan R, Cameron CE, Peterson BR. Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses. Journal of Medicinal Chemistry. November 2010, 53 (22): 7958–66. PMC 2990348  . PMID 20964406. doi:10.1021/jm100593s. 
  8. ^ Eyer L, Nencka R, Huvarová I, Palus M, Joao Alves M, Gould EA, et al. Nucleoside Inhibitors of Zika Virus. The Journal of Infectious Diseases. September 2016, 214 (5): 707–11. PMID 27234417. doi:10.1093/infdis/jiw226  . 
  9. ^ Zmurko J, Marques RE, Schols D, Verbeken E, Kaptein SJ, Neyts J. The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model. PLOS Neglected Tropical Diseases. May 2016, 10 (5): e0004695. PMC 4862633  . PMID 27163257. doi:10.1371/journal.pntd.0004695. 

十月 06, 2023
是一种抗病毒药物, 属于腺苷类似物, 一种核苷类似物, 英语, nucleoside, analog, 它最初由默克公司开发, 用于治疗丙型肝炎, 虽然它在动物研究中取得了较好的结果, 但最终在临床试验中失败, 后来, 它被广泛用于体外及动物的抗病毒研究, 并显示出对一系列病毒的活性, 如骨痛熱症, 蜱传脑炎病毒, 英语, tick, borne, encephalitis, virus, 脊髓灰質炎病毒, 以及茲卡病毒, 臨床資料其他名稱7, deaza, methyladenosine, 7dma法律規範狀態法. MK 608是一种抗病毒药物 属于腺苷类似物 一种核苷类似物 英语 nucleoside analog 它最初由默克公司开发 用于治疗丙型肝炎 虽然它在动物研究中取得了较好的结果 1 2 但最终在临床试验中失败 3 后来 它被广泛用于体外及动物的抗病毒研究 并显示出对一系列病毒的活性 如骨痛熱症 4 蜱传脑炎病毒 英语 tick borne encephalitis virus 5 脊髓灰質炎病毒 6 7 以及茲卡病毒 8 9 MK 608臨床資料其他名稱7 Deaza 2 C methyladenosine 7DMA法律規範狀態法律規範美 Investigational New Drug识别信息IUPAC命名法 2R 3R 4R 5R 2 4 Aminopyrrolo 2 3 d pyrimidin 7 yl 5 hydroxymethyl 3 methyloxolane 3 4 diolCAS号443642 29 3 PubChem CID3011893ChemSpider2280834UNIIQRR62J6WEFCompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID60963208化学信息化学式C 12H 16N 4O 4摩尔质量280 28 g mol 13D模型 JSmol 英语 JSmol 交互式图像SMILES C C 1 C H C H O C H 1n2ccc3c2ncnc3N CO O OInChI InChI 1S C12H16N4O4 c1 12 19 8 18 7 4 17 20 11 12 16 3 2 6 9 13 14 5 15 10 6 16 h2 3 5 7 8 11 17 19H 4H2 1H3 H2 13 14 15 t7 8 11 12 m1 s1Key IRZRJANZDIOOIF GAJNKVMBSA N参考文献 编辑 Carroll SS Ludmerer S Handt L Koeplinger K Zhang NR Graham D et al Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus infected chimpanzees Antimicrobial Agents and Chemotherapy March 2009 53 3 926 34 PMC 2650549 nbsp PMID 19075052 doi 10 1128 AAC 01032 08 Olsen DB Davies ME Handt L Koeplinger K Zhang NR Ludmerer SW et al Sustained viral response in a hepatitis C virus infected chimpanzee via a combination of direct acting antiviral agents Antimicrobial Agents and Chemotherapy February 2011 55 2 937 9 PMC 3028818 nbsp PMID 21115793 doi 10 1128 AAC 00990 10 Arnold JJ Sharma SD Feng JY Ray AS Smidansky ED Kireeva ML et al Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides PLOS Pathogens 2012 8 11 e1003030 PMC 3499576 nbsp PMID 23166498 doi 10 1371 journal ppat 1003030 Schul W Liu W Xu HY Flamand M Vasudevan SG A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs The Journal of Infectious Diseases March 2007 195 5 665 74 PMID 17262707 doi 10 1086 511310 nbsp Eyer L Valdes JJ Gil VA Nencka R Hrebabecky H Sala M et al Nucleoside inhibitors of tick borne encephalitis virus Antimicrobial Agents and Chemotherapy September 2015 59 9 5483 93 PMC 4538560 nbsp PMID 26124166 doi 10 1128 AAC 00807 15 Goris N De Palma A Toussaint JF Musch I Neyts J De Clercq K 2 C methylcytidine as a potent and selective inhibitor of the replication of foot and mouth disease virus Antiviral Research March 2007 73 3 161 8 PMID 17055073 doi 10 1016 j antiviral 2006 09 007 Wu R Smidansky ED Oh HS Takhampunya R Padmanabhan R Cameron CE Peterson BR Synthesis of a 6 methyl 7 deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses Journal of Medicinal Chemistry November 2010 53 22 7958 66 PMC 2990348 nbsp PMID 20964406 doi 10 1021 jm100593s Eyer L Nencka R Huvarova I Palus M Joao Alves M Gould EA et al Nucleoside Inhibitors of Zika Virus The Journal of Infectious Diseases September 2016 214 5 707 11 PMID 27234417 doi 10 1093 infdis jiw226 nbsp Zmurko J Marques RE Schols D Verbeken E Kaptein SJ Neyts J The Viral Polymerase Inhibitor 7 Deaza 2 C Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model PLOS Neglected Tropical Diseases May 2016 10 5 e0004695 PMC 4862633 nbsp PMID 27163257 doi 10 1371 journal pntd 0004695 取自 https zh wikipedia org w index php title MK 608 amp oldid 76861063, 维基百科，wiki，书籍，书籍，图书馆，

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