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维基百科

CGP-7930

CGP-7930(化学名: 2,6-二叔丁基-4-(3-羟基-2,2-二甲基丙基)-苯酚2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol)是一种有机化合物,是GABAB受体的正向别构调节剂,其作用效果和其同系物BSPP类似[1][2][3][4]

CGP-7930
识别信息
CAS号57717-80-3  
PubChem CID
  • 5024764
IUPHAR/BPS
  • 1079
ChemSpider
  • 4203613 N
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
  • DTXSID90407620
化学信息
化学式C19H32O2
摩尔质量292.46 g·mol−1
3D模型(JSmol英语JSmol
  • 交互式图像

参考文献

  1. ^ Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, et al. Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. Molecular Pharmacology. November 2001, 60 (5): 963–71. PMID 11641424. 
  2. ^ Binet V, Brajon C, Le Corre L, Acher F, Pin JP, Prézeau L. The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor. The Journal of Biological Chemistry. July 2004, 279 (28): 29085–91. PMID 15126507. doi:10.1074/jbc.M400930200 . 
  3. ^ Chen Y, Menendez-Roche N, Sher E. Differential modulation by the GABAB receptor allosteric potentiator 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area. The Journal of Pharmacology and Experimental Therapeutics. June 2006, 317 (3): 1170–7. PMID 16507713. doi:10.1124/jpet.105.099176. 
  4. ^ Adams CL, Lawrence AJ. CGP7930: a positive allosteric modulator of the GABAB receptor. CNS Drug Reviews: 308–16. PMC 6494120 . PMID 17894647. doi:10.1111/j.1527-3458.2007.00021.x. 

外部链接 

7930, 化学名, 二叔丁基, 羟基, 二甲基丙基, 苯酚, tert, butyl, hydroxy, dimethylpropyl, phenol, 是一种有机化合物, 是gabab受体的正向别构调节剂, 其作用效果和其同系物bspp类似, 识别信息iupac命名法, tert, butyl, hydroxy, dimethyl, propyl, phenolcas号57717, pubchem, cid5024764iuphar, bps1079chemspider4203613, ncomptox, da. CGP 7930 化学名 2 6 二叔丁基 4 3 羟基 2 2 二甲基丙基 苯酚 2 6 di tert butyl 4 3 hydroxy 2 2 dimethylpropyl phenol 是一种有机化合物 是GABAB受体的正向别构调节剂 其作用效果和其同系物BSPP类似 1 2 3 4 CGP 7930识别信息IUPAC命名法 2 6 Di tert butyl 4 3 hydroxy 2 2 dimethyl propyl phenolCAS号57717 80 3 PubChem CID5024764IUPHAR BPS1079ChemSpider4203613 NCompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID90407620化学信息化学式C 19H 32O 2摩尔质量292 46 g mol 13D模型 JSmol 英语 JSmol 交互式图像SMILES CC C C c1cc CC C C CO cc C C C C c1OInChI InChI 1S C19H32O2 c1 17 2 3 14 9 13 11 19 7 8 12 20 10 15 16 14 21 18 4 5 6 h9 10 20 21H 11 12H2 1 8H3 NKey XLWJPQQFJNGUPA UHFFFAOYSA N N参考文献 编辑 Urwyler S Mosbacher J Lingenhoehl K Heid J Hofstetter K Froestl W et al Positive allosteric modulation of native and recombinant gamma aminobutyric acid B receptors by 2 6 Di tert butyl 4 3 hydroxy 2 2 dimethyl propyl phenol CGP7930 and its aldehyde analog CGP13501 Molecular Pharmacology November 2001 60 5 963 71 PMID 11641424 Binet V Brajon C Le Corre L Acher F Pin JP Prezeau L The heptahelical domain of GABA B2 is activated directly by CGP7930 a positive allosteric modulator of the GABA B receptor The Journal of Biological Chemistry July 2004 279 28 29085 91 PMID 15126507 doi 10 1074 jbc M400930200 Chen Y Menendez Roche N Sher E Differential modulation by the GABAB receptor allosteric potentiator 2 6 di tert butyl 4 3 hydroxy 2 2 dimethylpropyl phenol CGP7930 of synaptic transmission in the rat hippocampal CA1 area The Journal of Pharmacology and Experimental Therapeutics June 2006 317 3 1170 7 PMID 16507713 doi 10 1124 jpet 105 099176 Adams CL Lawrence AJ CGP7930 a positive allosteric modulator of the GABAB receptor CNS Drug Reviews 308 16 PMC 6494120 PMID 17894647 doi 10 1111 j 1527 3458 2007 00021 x 外部链接 编辑 维基共享资源上的相關多媒體資源 CGP 7930 取自 https zh wikipedia org w index php title CGP 7930 amp oldid 63702463, 维基百科,wiki,书籍,书籍,图书馆,

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