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BRL-37344

BRL-37344是一种药物,分子式C19H22ClNO4,为β-3肾上腺素英语Beta-3 adrenergic receptor受体选择性激动剂[1]已针对各种生物医学的应用开展了相关研究,但尚未提供临床使用。[2][3][4][5][6][7]

BRL-37344
臨床資料
商品名英语Drug nomenclatureBRL-37344
法律規範狀態
法律規範
  • : Investigational New Drug
识别信息
CAS号114333-71-0
PubChem CID
  • 9841972
化学信息
化学式C19H22ClNO4
摩尔质量363.8
3D模型(JSmol英语JSmol
  • 交互式图像

参考文献

  1. ^ Bond RA, Clarke DE. Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the alpha- and beta-subtypes. British Journal of Pharmacology. November 1988, 95 (3): 723–34. PMC 1854239 . PMID 2905184. doi:10.1111/j.1476-5381.1988.tb11698.x. 
  2. ^ Napp A, Brixius K, Pott C, Ziskoven C, Boelck B, Mehlhorn U, et al. Effects of the beta3-adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium. Journal of Cardiac Failure. February 2009, 15 (1): 57–67. PMID 19181295. doi:10.1016/j.cardfail.2008.08.006. 
  3. ^ Afeli SA, Rovner ES, Petkov GV. BRL37344, a β3-adrenergic receptor agonist, decreases nerve-evoked contractions in human detrusor smooth muscle isolated strips: role of BK channels. Urology. September 2013, 82 (3): 744.e1–7. PMC 3758792 . PMID 23890664. doi:10.1016/j.urology.2013.05.027. 
  4. ^ Maryanovich M, Zahalka AH, Pierce H, Pinho S, Nakahara F, Asada N, et al. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nature Medicine. June 2018, 24 (6): 782–791. PMC 6095812 . PMID 29736022. doi:10.1038/s41591-018-0030-x. 
  5. ^ Xu Z, Wu J, Xin J, Feng Y, Hu G, Shen J, et al. β3-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway. Biochemical and Biophysical Research Communications. September 2018, 503 (1): 146–151. PMID 29859189. doi:10.1016/j.bbrc.2018.05.200. 
  6. ^ Grzelka K, Gawlak M, Czarzasta K, Szulczyk P. β3-adrenergic receptor stimulation on the resting holding current of medial prefrontal cortex pyramidal neurons in young rats. Neuroscience Letters. April 2019, 698: 192–197. PMID 30641111. doi:10.1016/j.neulet.2019.01.022. 
  7. ^ Fellous TG, Redpath AN, Fleischer MM et al. Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery. npj Regen Med 2020; 5: 3. doi:10.1038/s41536-020-0088-1

37344, 是一种药物, 分子式c19h22clno4, 为β, 3肾上腺素, 英语, beta, adrenergic, receptor, 受体选择性激动剂, 已针对各种生物医学的应用开展了相关研究, 但尚未提供临床使用, 臨床資料商品名, 英语, drug, nomenclature, 法律規範狀態法律規範美, investigational, drug识别信息iupac命名法, chlorophenyl, hydroxyethyl, amino, propyl, phenoxy, acetic, acid. BRL 37344是一种药物 分子式C19H22ClNO4 为b 3肾上腺素 英语 Beta 3 adrenergic receptor 受体选择性激动剂 1 已针对各种生物医学的应用开展了相关研究 但尚未提供临床使用 2 3 4 5 6 7 BRL 37344臨床資料商品名 英语 Drug nomenclature BRL 37344法律規範狀態法律規範美 Investigational New Drug识别信息IUPAC命名法 2 4 2R 2 2R 2 3 chlorophenyl 2 hydroxyethyl amino propyl phenoxy acetic acidCAS号114333 71 0PubChem CID9841972化学信息化学式C 19H 22Cl N O 4摩尔质量363 83D模型 JSmol 英语 JSmol 交互式图像SMILES C C H CC1 CC C C C1 OCC O O NC C H C2 CC CC C2 Cl OInChI InChI 1S C19H22ClNO4 c1 13 21 11 18 22 15 3 2 4 16 20 10 15 9 14 5 7 17 8 6 14 25 12 19 23 24 h2 8 10 13 18 21 22H 9 11 12H2 1H3 H 23 24 t13 18 m1 s1Key ZGGNJJJYUVRADP ACJLOTCBSA N参考文献 编辑 Bond RA Clarke DE Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the alpha and beta subtypes British Journal of Pharmacology November 1988 95 3 723 34 PMC 1854239 PMID 2905184 doi 10 1111 j 1476 5381 1988 tb11698 x Napp A Brixius K Pott C Ziskoven C Boelck B Mehlhorn U et al Effects of the beta3 adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium Journal of Cardiac Failure February 2009 15 1 57 67 PMID 19181295 doi 10 1016 j cardfail 2008 08 006 Afeli SA Rovner ES Petkov GV BRL37344 a b3 adrenergic receptor agonist decreases nerve evoked contractions in human detrusor smooth muscle isolated strips role of BK channels Urology September 2013 82 3 744 e1 7 PMC 3758792 PMID 23890664 doi 10 1016 j urology 2013 05 027 Maryanovich M Zahalka AH Pierce H Pinho S Nakahara F Asada N et al Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche Nature Medicine June 2018 24 6 782 791 PMC 6095812 PMID 29736022 doi 10 1038 s41591 018 0030 x Xu Z Wu J Xin J Feng Y Hu G Shen J et al b3 adrenergic receptor activation induces TGFb1 expression in cardiomyocytes via the PKG JNK c Jun pathway Biochemical and Biophysical Research Communications September 2018 503 1 146 151 PMID 29859189 doi 10 1016 j bbrc 2018 05 200 Grzelka K Gawlak M Czarzasta K Szulczyk P b3 adrenergic receptor stimulation on the resting holding current of medial prefrontal cortex pyramidal neurons in young rats Neuroscience Letters April 2019 698 192 197 PMID 30641111 doi 10 1016 j neulet 2019 01 022 Fellous TG Redpath AN Fleischer MM et al Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery npj Regen Med 2020 5 3 doi 10 1038 s41536 020 0088 1 这是一篇與药学相關的小作品 你可以通过编辑或修订扩充其内容 查论编 取自 https zh wikipedia org w index php title BRL 37344 amp oldid 68256589, 维基百科,wiki,书籍,书籍,图书馆,

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