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维基百科

7-甲基辛酸

行進 31, 2023

7-甲基辛酸是一种有机化合物，化学式为C9H18O2，它是异壬酸（德语：Isononansäure）的同分异构体之一。[4]

7-甲基辛酸
英文名 7-Methyloctanoic acid
识别
CAS号 693-19-6  
SMILES
性质
化学式 C9H18O2
摩尔质量 158.24 g·mol⁻¹
密度 0.919±0.06 g·cm−3[1]
熔点 3－5 °C（276－278 K）[2]
沸点 248 °C（521 K）（765 Torr）[3]
溶解性（水） 0.11 g[1]
pKa 4.78±0.10[1]
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

制备

7-甲基辛酸可由7-甲基辛醇和吡啶重铬酸盐（或三氧化铬[2]）的氧化反应制得。[5]6-溴己酸钠和异丙基氯化镁反应，酸化后加水可以析出7-甲基辛酸。[6]

7-甲基辛酸甲酯在碱性条件下水解[7]，或7-甲基-7-辛烯酸在钯碳的催化下由氢气还原，也能得到产物。[8]

性质

7-甲基辛酸和光气加热反应，得到7-甲基辛酰氯；[9]在酸性催化剂的催化下，也能和醇反应生成酯。[10][11]

参考文献

  1. ^ 1.0 1.1 1.2 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ((C) 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-07-25].
  2. ^ 2.0 2.1 Klimentová, Jana; Kosák, Petr; Vávrová, Kateřina; Holas, Tomáš; Hrabálek, Alexandr. Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids. Bioorganic & Medicinal Chemistry. 2006, 14 (23): 7681–7687. ISSN 0968-0896. doi:10.1016/j.bmc.2006.08.013. 
  3. ^ Levene, P. A.; Allen, C. H. The oxidation of branched-chain fatty acids. I. The action of hydrogen peroxide on the homologs of isobutyric acid. Journal of Biological Chemistry, 1916. 27: 433-462. ISSN: 0021-9258.
  4. ^ Isononansäure Nr.276. (PDF) (PDF). Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI). 2010 [2020-07-25]. （原始内容 (PDF)于2016-03-24）. 
  5. ^ Cooper, Matthew; Blaskovich, Mark; Alejandra, Gallardo-Goday; Hansford, Karl; Elliott, Alysha. Peptide antibiotics. 2019. WO 2019084628 A1.
  6. ^ Thiel, Verena; Kunze, Brigitte; Verma, Pankaj; Wagner-Döbler, Irene; Schulz, Stefan. New Structural Variants of Homoserine Lactones in Bacteria. ChemBioChem. 2009, 10 (11): 1861–1868. ISSN 1439-4227. doi:10.1002/cbic.200900126. 
  7. ^ Riclea, Ramona; Aigle, Bertrand; Leblond, Pierre; Schoenian, Ilka; Spiteller, Dieter; Dickschat, Jeroen S. Volatile Lactones from Streptomycetes Arise via the Antimycin Biosynthetic Pathway. ChemBioChem. 2012, 13 (11): 1635–1644. ISSN 1439-4227. doi:10.1002/cbic.201200260. 
  8. ^ Cui, A-Long; Hu, Xin-Xin; Gao, Yan; Jin, Jie; Yi, Hong; Wang, Xiu-Kun; Nie, Tong-Ying; Chen, Yang; He, Qi-Yang; Guo, Hui-Fang; Jiang, Jian-Dong; You, Xue-Fu; Li, Zhuo-Rong. Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics. Journal of Medicinal Chemistry. 2018, 61 (5): 1845–1857. ISSN 0022-2623. doi:10.1021/acs.jmedchem.7b01367. 
  9. ^ Lan, Xingfen; Qiu, Xuenan; Peng, Jiuhe. Process for preparation of acyl chloride compounds. 2016. CN 105585478 A.
  10. ^ Springer, Helmut; Merscher, Klaus-Dieter; Heumueller, Rudolf; Schimmer, Klaus; Strutz, Heinz. Process for the production of glycol-carboxylate ester plasticizers with the azeotropic distillative removal of process water. 2001. DE 19940991 A1.
  11. ^ Mun, Dasom; Vo, Anh Thi Hoang; Kim, Bora; Shul, Yong-Gun; Cho, Jin Ku. Solventless esterification of fatty acids with trimethylolpropane using sulfonated amorphous carbons derived from wood powder. Catalysis Communications. 2017, 96: 32–36. ISSN 1566-7367. doi:10.1016/j.catcom.2017.03.015. 

行進 31, 2023
甲基辛酸, 是一种有机化合物, 化学式为c9h18o2, 它是异壬酸, 德语, isononansäure, 的同分异构体之一, 英文名, methyloctanoic, acid识别cas号, smiles, cccccc, o性质化学式, c9h18o2摩尔质量, 密度, 熔点, 沸点, torr, 溶解性, 若非注明, 所有数据均出自标准状态, 制备, 编辑可由7, 甲基辛醇和吡啶重铬酸盐, 或三氧化铬, 的氧化反应制得, 溴己酸钠和异丙基氯化镁反应, 酸化后加水可以析出, 甲酯在碱性条件下水解, 或7, 甲. 7 甲基辛酸是一种有机化合物 化学式为C9H18O2 它是异壬酸 德语 Isononansaure 的同分异构体之一 4 7 甲基辛酸英文名 7 Methyloctanoic acid识别CAS号 693 19 6 SMILES CC C CCCCCC O O性质化学式 C9H18O2摩尔质量 158 24 g mol 密度 0 919 0 06 g cm 3 1 熔点 3 5 C 276 278 K 2 沸点 248 C 521 K 765 Torr 3 溶解性 水 0 11 g 1 pKa 4 78 0 10 1 若非注明 所有数据均出自标准状态 25 100 kPa 下 制备 编辑7 甲基辛酸可由7 甲基辛醇和吡啶重铬酸盐 或三氧化铬 2 的氧化反应制得 5 6 溴己酸钠和异丙基氯化镁反应 酸化后加水可以析出7 甲基辛酸 6 7 甲基辛酸甲酯在碱性条件下水解 7 或7 甲基 7 辛烯酸在钯碳的催化下由氢气还原 也能得到产物 8 性质 编辑7 甲基辛酸和光气加热反应 得到7 甲基辛酰氯 9 在酸性催化剂的催化下 也能和醇反应生成酯 10 11 参考文献 编辑 1 0 1 1 1 2 Calculated using Advanced Chemistry Development ACD Labs Software V11 02 C 1994 2020 ACD Labs Retrieved from SciFinder 2020 07 25 2 0 2 1 Klimentova Jana Kosak Petr Vavrova Katerina Holas Tomas Hrabalek Alexandr Influence of terminal branching on the transdermal permeation enhancing activity in fatty alcohols and acids Bioorganic amp Medicinal Chemistry 2006 14 23 7681 7687 ISSN 0968 0896 doi 10 1016 j bmc 2006 08 013 Levene P A Allen C H The oxidation of branched chain fatty acids I The action of hydrogen peroxide on the homologs of isobutyric acid Journal of Biological Chemistry 1916 27 433 462 ISSN 0021 9258 Isononansaure Nr 276 PDF PDF Berufsgenossenschaft Rohstoffe und chemische Industrie BG RCI 2010 2020 07 25 原始内容存档 PDF 于2016 03 24 Cooper Matthew Blaskovich Mark Alejandra Gallardo Goday Hansford Karl Elliott Alysha Peptide antibiotics 2019 WO 2019084628 A1 Thiel Verena Kunze Brigitte Verma Pankaj Wagner Dobler Irene Schulz Stefan New Structural Variants of Homoserine Lactones in Bacteria ChemBioChem 2009 10 11 1861 1868 ISSN 1439 4227 doi 10 1002 cbic 200900126 Riclea Ramona Aigle Bertrand Leblond Pierre Schoenian Ilka Spiteller Dieter Dickschat Jeroen S Volatile Lactones from Streptomycetes Arise via the Antimycin Biosynthetic Pathway ChemBioChem 2012 13 11 1635 1644 ISSN 1439 4227 doi 10 1002 cbic 201200260 Cui A Long Hu Xin Xin Gao Yan Jin Jie Yi Hong Wang Xiu Kun Nie Tong Ying Chen Yang He Qi Yang Guo Hui Fang Jiang Jian Dong You Xue Fu Li Zhuo Rong Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics Journal of Medicinal Chemistry 2018 61 5 1845 1857 ISSN 0022 2623 doi 10 1021 acs jmedchem 7b01367 Lan Xingfen Qiu Xuenan Peng Jiuhe Process for preparation of acyl chloride compounds 2016 CN 105585478 A Springer Helmut Merscher Klaus Dieter Heumueller Rudolf Schimmer Klaus Strutz Heinz Process for the production of glycol carboxylate ester plasticizers with the azeotropic distillative removal of process water 2001 DE 19940991 A1 Mun Dasom Vo Anh Thi Hoang Kim Bora Shul Yong Gun Cho Jin Ku Solventless esterification of fatty acids with trimethylolpropane using sulfonated amorphous carbons derived from wood powder Catalysis Communications 2017 96 32 36 ISSN 1566 7367 doi 10 1016 j catcom 2017 03 015 取自 https zh wikipedia org w index php title 7 甲基辛酸 amp oldid 72313922, 维基百科，wiki，书籍，书籍，图书馆，

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