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维基百科

4-羟基苯基丙酮

行進 31, 2023

4-羟基苯基丙酮（4-Hydroxyphenylacetone）是苯基丙酮（苯丙胺在人体中的不活泼代谢产物）的羟基类似物。[1][2]当它作为苯丙胺的代谢产物出现时，它通常是由不活泼的代谢物苯基丙酮中直接产生。[1][3]

4-羟基苯基丙酮
IUPAC名
1-(4-Hydroxyphenyl)propan-2-one
别名 p-Hydroxyphenylacetone; para-Hydroxyphenylacetone
识别
CAS号 770-39-8
PubChem 7019274
ChemSpider 5382241
SMILES
InChI
InChIKey VWMVAQHMFFZQGD-UHFFFAOYSA-N
性质
化学式 C9H10O2
摩尔质量 150.17 g·mol−1
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。
苯丙胺的代謝途徑[sources 1]
4-Hydroxyamphetamine（英语：4-Hydroxyamphetamine）
4-Hydroxynorephedrine（英语：p-Hydroxynorephedrine）
Para-
Hydroxylation
Para-
Hydroxylation
Para-
Hydroxylation
Beta-
Hydroxylation
Beta-
Hydroxylation
Oxidative
Deamination
Oxidation
Glycine
Conjugation
人体中，4-羟基苯基丙酮是苯丙胺和苯基丙酮的代谢产物。

参注

  1. ^ [3][4][5][6][7][8][9][10]

参考资料

  1. ^ 1.0 1.1 Santagati NA, Ferrara G, Marrazzo A, Ronsisvalle G. Simultaneous determination of amphetamine and one of its metabolites by HPLC with electrochemical detection. J. Pharm. Biomed. Anal. September 2002, 30 (2): 247–55. PMID 12191709. doi:10.1016/S0731-7085(02)00330-8. 
  2. ^ 4-Hydroxyphenylacetone. NCBI. PubChem Compound. [2013-10-25]. （原始内容于2014-01-08）. 
  3. ^ 3.0 3.1 Adderall XR Prescribing Information (PDF). United States Food and Drug Administration. Shire US Inc: 12–13. December 2013 [30 December 2013]. （原始内容 (PDF)于2018-07-18）. 
  4. ^ Glennon RA. Phenylisopropylamine stimulants: amphetamine-related agents. Lemke TL, Williams DA, Roche VF, Zito W (编). Foye's principles of medicinal chemistry 7th. Philadelphia, USA: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2013: 646–648 [2018-06-20]. ISBN 9781609133450. （原始内容于2020-07-26）. 
  5. ^ Taylor KB. Dopamine-beta-hydroxylase. Stereochemical course of the reaction (PDF). J. Biol. Chem. January 1974, 249 (2): 454–458 [6 November 2014]. PMID 4809526. （原始内容 (PDF)于2019-04-04）. 
  6. ^ Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol. Ther. June 2005, 106 (3): 357–387. PMC 1828602  . PMID 15922018. doi:10.1016/j.pharmthera.2005.01.001. 
    Table 5: N-containing drugs and xenobiotics oxygenated by FMO （页面存档备份，存于互联网档案馆）
  7. ^ Cashman JR, Xiong YN, Xu L, Janowsky A. N-oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication. J. Pharmacol. Exp. Ther. March 1999, 288 (3): 1251–1260. PMID 10027866. 
  8. ^ Santagati NA, Ferrara G, Marrazzo A, Ronsisvalle G. Simultaneous determination of amphetamine and one of its metabolites by HPLC with electrochemical detection. J. Pharm. Biomed. Anal. September 2002, 30 (2): 247–255. PMID 12191709. doi:10.1016/S0731-7085(02)00330-8. 
  9. ^ Sjoerdsma A, von Studnitz W. Dopamine-beta-oxidase activity in man, using hydroxyamphetamine as substrate. Br. J. Pharmacol. Chemother. April 1963, 20: 278–284. PMC 1703637  . PMID 13977820. doi:10.1111/j.1476-5381.1963.tb01467.x. 
  10. ^ Badenhorst CP, van der Sluis R, Erasmus E, van Dijk AA. Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation. Expert Opin. Drug Metab. Toxicol. September 2013, 9 (9): 1139–1153. PMID 23650932. doi:10.1517/17425255.2013.796929. 

外部链接

行進 31, 2023
羟基苯基丙酮, 此條目需要精通或熟悉化学的编者参与及协助编辑, 請邀請適合的人士改善本条目, 更多的細節與詳情請參见討論頁, 另見其他需要化学專家關注的頁面, 此條目需要擴充, 2018年2月26日, 请協助改善这篇條目, 更進一步的信息可能會在討論頁或扩充请求中找到, 请在擴充條目後將此模板移除, hydroxyphenylacetone, 是苯基丙酮, 苯丙胺在人体中的不活泼代谢产物, 的羟基类似物, 当它作为苯丙胺的代谢产物出现时, 它通常是由不活泼的代谢物苯基丙酮中直接产生, iupac名1, hydrox. 此條目需要精通或熟悉化学的编者参与及协助编辑 請邀請適合的人士改善本条目 更多的細節與詳情請參见討論頁 另見其他需要化学專家關注的頁面 此條目需要擴充 2018年2月26日 请協助改善这篇條目 更進一步的信息可能會在討論頁或扩充请求中找到 请在擴充條目後將此模板移除 4 羟基苯基丙酮 4 Hydroxyphenylacetone 是苯基丙酮 苯丙胺在人体中的不活泼代谢产物 的羟基类似物 1 2 当它作为苯丙胺的代谢产物出现时 它通常是由不活泼的代谢物苯基丙酮中直接产生 1 3 4 羟基苯基丙酮IUPAC名1 4 Hydroxyphenyl propan 2 one别名 p Hydroxyphenylacetone para Hydroxyphenylacetone识别CAS号 770 39 8PubChem 7019274ChemSpider 5382241SMILES CC O CC1 CC C C C1 OInChI 1S C9H10O2 c1 7 10 6 8 2 4 9 11 5 3 8 h2 5 11H 6H2 1H3InChIKey VWMVAQHMFFZQGD UHFFFAOYSA N性质化学式 C9H10O2摩尔质量 150 17 g mol 1若非注明 所有数据均出自标准状态 25 100 kPa 下 苯丙胺的代謝途徑 sources 1 4 羟基苯基丙酮 苯基丙酮 苯甲酸 馬尿酸 苯丙胺 苯丙醇胺 4 Hydroxyamphetamine 英语 4 Hydroxyamphetamine 4 Hydroxynorephedrine 英语 p Hydroxynorephedrine Para Hydroxylation Para Hydroxylation Para Hydroxylation Beta Hydroxylation Beta Hydroxylation OxidativeDeamination Oxidation GlycineConjugation 人体中 4 羟基苯基丙酮是苯丙胺和苯基丙酮的代谢产物 参注 编辑 3 4 5 6 7 8 9 10 参考资料 编辑 1 0 1 1 Santagati NA Ferrara G Marrazzo A Ronsisvalle G Simultaneous determination of amphetamine and one of its metabolites by HPLC with electrochemical detection J Pharm Biomed Anal September 2002 30 2 247 55 PMID 12191709 doi 10 1016 S0731 7085 02 00330 8 4 Hydroxyphenylacetone NCBI PubChem Compound 2013 10 25 原始内容存档于2014 01 08 3 0 3 1 Adderall XR Prescribing Information PDF United States Food and Drug Administration Shire US Inc 12 13 December 2013 30 December 2013 原始内容存档 PDF 于2018 07 18 Glennon RA Phenylisopropylamine stimulants amphetamine related agents Lemke TL Williams DA Roche VF Zito W 编 Foye s principles of medicinal chemistry 7th Philadelphia USA Wolters Kluwer Health Lippincott Williams amp Wilkins 2013 646 648 2018 06 20 ISBN 9781609133450 原始内容存档于2020 07 26 Taylor KB Dopamine beta hydroxylase Stereochemical course of the reaction PDF J Biol Chem January 1974 249 2 454 458 6 November 2014 PMID 4809526 原始内容存档 PDF 于2019 04 04 Krueger SK Williams DE Mammalian flavin containing monooxygenases structure function genetic polymorphisms and role in drug metabolism Pharmacol Ther June 2005 106 3 357 387 PMC 1828602 PMID 15922018 doi 10 1016 j pharmthera 2005 01 001 Table 5 N containing drugs and xenobiotics oxygenated by FMO 页面存档备份 存于互联网档案馆 Cashman JR Xiong YN Xu L Janowsky A N oxygenation of amphetamine and methamphetamine by the human flavin containing monooxygenase form 3 role in bioactivation and detoxication J Pharmacol Exp Ther March 1999 288 3 1251 1260 PMID 10027866 Santagati NA Ferrara G Marrazzo A Ronsisvalle G Simultaneous determination of amphetamine and one of its metabolites by HPLC with electrochemical detection J Pharm Biomed Anal September 2002 30 2 247 255 PMID 12191709 doi 10 1016 S0731 7085 02 00330 8 Sjoerdsma A von Studnitz W Dopamine beta oxidase activity in man using hydroxyamphetamine as substrate Br J Pharmacol Chemother April 1963 20 278 284 PMC 1703637 PMID 13977820 doi 10 1111 j 1476 5381 1963 tb01467 x Badenhorst CP van der Sluis R Erasmus E van Dijk AA Glycine conjugation importance in metabolism the role of glycine N acyltransferase and factors that influence interindividual variation Expert Opin Drug Metab Toxicol September 2013 9 9 1139 1153 PMID 23650932 doi 10 1517 17425255 2013 796929 外部链接 编辑醫學主題詞表 MeSH 4 hydroxyphenylacetone 取自 https zh wikipedia org w index php title 4 羟基苯基丙酮 amp oldid 75777489, 维基百科，wiki，书籍，书籍，图书馆，

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