^Smith, B. J.; McKimm-Breshkin, J. L.; McDonald, M.; Fernley, R. T.; Varghese, J. N.; Colman, P. M. Structural Studies of the Resistance of Influenza Virus Neuramindase to Inhibitors. Journal of Medicinal Chemistry. 2002, 45 (11): 2207–12. PMID 12014958. doi:10.1021/jm010528u.
^Gubareva, Larisa V. Molecular mechanisms of influenza virus resistance to neuraminidase inhibitors. Virus Research. 2004, 103 (1–2): 199–203. PMID 15163510. doi:10.1016/j.virusres.2004.02.034.
^This flash animation shows the mode of action of oseltamivir (Tamiflu) 互联网档案馆的，存档日期2005-10-23.. pharmasquare.org
^Replication of influenza virus （页面存档备份，存于互联网档案馆）. mvm.ed.ac.uk
^Bantia, Shanta; Arnold, C. Shane; Parker, Cynthia D.; Upshaw, Ramanda; Chand, Pooran. Anti-influenza virus activity of peramivir in mice with single intramuscular injection. Antiviral Research. 1 January 2006, 69 (1): 39–45. ISSN 0166-3542. PMID 16325932. doi:10.1016/j.antiviral.2005.10.002.
^Ishizuka, Hitoshi; Yoshiba, Satoshi; Okabe, Hiromi; Yoshihara, Kazutaka. Clinical pharmacokinetics of laninamivir, a novel long-acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers. Journal of Clinical Pharmacology. 1 November 2010, 50 (11): 1319–1329. ISSN 1552-4604. PMID 20145259. doi:10.1177/0091270009356297.
^Jefferson, Tom; Jones, Mark; Doshi, Peter; Spencer, Elizabeth A.; Onakpoya, Igho; Heneghan, Carl J. Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. BMJ. 9 April 2014, 348: g2545 [2021-01-15]. ISSN 1756-1833. PMC 3981975. PMID 24811411. doi:10.1136/bmj.g2545. （原始内容于2019-10-31）.
^Hsu, Jonathan; Santesso, Nancy; Mustafa, Reem; Brozek, Jan; Chen, Yao Long; Hopkins, Jessica P.; Cheung, Adrienne; Hovhannisyan, Gayane; Ivanova, Liudmila; Flottorp, Signe A.; Saeterdal, Ingvil; Wong, Arthur D.; Tian, Jinhui; Uyeki, Timothy M.; Akl, Elie A.; Alonso-Coello, Pablo; Smaill, Fiona; Schünemann, Holger J. Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies. Annals of Internal Medicine. 3 April 2012, 156 (7): 512–524. ISSN 1539-3704. PMC 6679687. PMID 22371849. doi:10.7326/0003-4819-156-7-201204030-00411.
^Heneghan, Carl J.; Onakpoya, Igho; Thompson, Matthew; Spencer, Elizabeth A.; Jones, Mark; Jefferson, Tom. Zanamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. BMJ. 9 April 2014, 348: g2547 [2021-01-15]. ISSN 1756-1833. PMC 3981976. PMID 24811412. doi:10.1136/bmj.g2547. （原始内容于2021-03-23）.
^Louie, Janice K.; Acosta, Meileen; Jamieson, Denise J.; Honein, Margaret A. Severe 2009 H1N1 Influenza in Pregnant and Postpartum Women in California. New England Journal of Medicine. 2010, 362 (1): 27–35. PMID 20032319. doi:10.1056/nejmoa0910444.
^Jain, Seema; Kamimoto, Laurie; Bramley, Anna M.; Schmitz, Ann M.; Benoit, Stephen R.; Louie, Janice; Sugerman, David E.; Druckenmiller, Jean K.; Ritger, Kathleen A.; Chugh, Rashmi; Jasuja, Supriya; Deutscher, Meredith; Chen, Sanny; Walker, John D.; Duchin, Jeffrey S.; Lett, Susan; Soliva, Susan; Wells, Eden V.; Swerdlow, David; Uyeki, Timothy M.; Fiore, Anthony E.; Olsen, Sonja J.; Fry, Alicia M.; Bridges, Carolyn B.; Finelli, Lyn. Hospitalized Patients with 2009 H1N1 Influenza in the United States, April–June 2009. New England Journal of Medicine. 12 November 2009, 361 (20): 1935–1944. CiteSeerX 10.1.1.183.7888. ISSN 0028-4793. PMID 19815859. doi:10.1056/NEJMoa0906695.
^Domínguez-Cherit, Guillermo; Lapinsky, Stephen E.; Macias, Alejandro E.; Pinto, Ruxandra; Espinosa-Perez, Lourdes; de la Torre, Alethse; Poblano-Morales, Manuel; Baltazar-Torres, Jose A.; Bautista, Edgar; Martinez, Abril; Martinez, Marco A.; Rivero, Eduardo; Valdez, Rafael; Ruiz-Palacios, Guillermo; Hernández, Martín; Stewart, Thomas E.; Fowler, Robert A. Critically Ill patients with 2009 influenza A(H1N1) in Mexico. JAMA. 4 November 2009, 302 (17): 1880–1887. ISSN 1538-3598. PMID 19822626. doi:10.1001/jama.2009.1536.
^Zarychanski, R.; Stuart, T. L.; Kumar, A.; Doucette, S.; Elliott, L.; Kettner, J.; Plummer, F. Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection. Canadian Medical Association Journal. 2010, 182 (3): 257–264. ISSN 0820-3946. PMC 2826467. PMID 20093297. doi:10.1503/cmaj.091884.
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^Swaminathan K, Dyason JC, Maggioni A, von Itzstein M, Downard KM. Binding of a natural anthocyanin inhibitor to influenza neuraminidase by mass spectrometry. Anal Bioanal Chem. 2013, 405 (20): 6563–72. PMID 23748498. doi:10.1007/s00216-013-7068-x.
^Kim, Jang Hoon; Ryu, Young Bae; Lee, Woo Song; Kim, Young Ho. Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome. Bioorganic & Medicinal Chemistry. 2014-11-01, 22 (21): 6047–6052. ISSN 1464-3391. PMID 25277281. doi:10.1016/j.bmc.2014.09.004.
十月 31, 2023
神经氨酸酶抑制剂, neuraminidase, inhibitors, nais, 是一类抑制神经氨酸酶活性的抗病毒药物, 其通过阻断流感病毒的神经氨酸酶, 从而阻止病毒出芽, 进而抑制病毒繁殖, 包括奥司他韦, 达菲, 一种前药, 扎那米韦, 乐感清, 拉尼米韦, inavir, 帕拉米韦及一系列正在研发中的新药, 与仅对甲型流感起作用的m2离子通道蛋白抑制剂不同, 对甲型流感和乙型流感均有效, 奥司他韦和扎那米韦在美国和欧洲被批准用于治疗和预防流感, 帕拉米韦通过结合并抑制流感病毒的神经氨酸酶活化而产生药理活. 神经氨酸酶抑制剂 neuraminidase inhibitors NAIs 是一类抑制神经氨酸酶活性的抗病毒药物 其通过阻断流感病毒的神经氨酸酶 从而阻止病毒出芽 进而抑制病毒繁殖 神经氨酸酶抑制剂包括奥司他韦 达菲 一种前药 扎那米韦 乐感清 拉尼米韦 Inavir 帕拉米韦及一系列正在研发中的新药 与仅对甲型流感起作用的M2离子通道蛋白抑制剂不同 神经氨酸酶抑制剂对甲型流感和乙型流感均有效 1 2 3 4 神经氨酸酶抑制剂奥司他韦和扎那米韦在美国和欧洲被批准用于治疗和预防流感 帕拉米韦通过结合并抑制流感病毒的神经氨酸酶活化而产生药理活性 其作用时间比奥司他韦和扎那米韦都要长 5 拉尼米韦从细胞中缓慢释放进入呼吸道 其抗流感病毒作用同样持久 但其维持持久作用的机理不同于帕拉米韦 6 近年来 神经氨酸酶抑制剂的疗效备受争议 7 8 9 然而 在2009年H1N1流感大流行之后 许多国家和地区都宣称流感早期使用神经氨酸酶抑制剂治疗可有效减少严重病例和死亡率 10 11 12 13 统计报告显示 全国 地区范围内使用神经氨酸酶抑制剂治疗流感样疾病的国家和地区中 有症状感染者的死亡率很低 这是因为这些国家普遍在流感患者感染早期便使用神经氨酸酶抑制剂 14 尽管这些国家和地区广泛使用奥司他韦 但尚未出现对奥司他韦具有耐药性的流感病毒引起的爆发 也没有出现对奥司他韦具有耐药性的流感病毒引起的严重疾病的报道 14 美国疾病控制中心仍然建议并发症相关高危人群 老年人以及首次出现流感相关症状后48小时内的低危人群使用奥司他韦治疗流感 15 神经氨酸酶抑制剂常见的副作用为恶心和呕吐 已有报道称儿童服用奥司他韦后可出现行为异常 如谵妄和幻觉 这可能是流感相关症状的延伸 14 这些副作用一般发生于流感早期 即流感病发后48小时内 因此 专家建议 无论患儿是否接受神经氨酸酶抑制剂治疗 父母都应密切监视流感病发后48小时内的患儿体征 14 目录 1 常见神经氨酸酶抑制剂 1 1 临床使用的神经氨酸酶抑制剂结构 2 天然产物中的神经氨酸酶抑制剂 3 参考文献常见神经氨酸酶抑制剂 编辑奥司他韦 达菲 帕拉米韦 Rapivab 扎那米韦 乐感清 拉尼米韦临床使用的神经氨酸酶抑制剂结构 编辑 Viral neuraminidase inhibitors in use nbsp nbsp nbsp nbsp 扎那米韦 奥司他韦 帕拉米韦 拉尼米韦天然产物中的神经氨酸酶抑制剂 编辑矢车菊素 3 桑布双糖苷 从西洋接骨木中提取 16 黄连碱 黄连素 17 参考文献 编辑 Smith B J McKimm Breshkin J L McDonald M Fernley R T Varghese J N Colman P M Structural Studies of the Resistance of Influenza Virus Neuramindase to Inhibitors Journal of Medicinal Chemistry 2002 45 11 2207 12 PMID 12014958 doi 10 1021 jm010528u Gubareva Larisa V Molecular mechanisms of influenza virus resistance to neuraminidase inhibitors Virus Research 2004 103 1 2 199 203 PMID 15163510 doi 10 1016 j virusres 2004 02 034 This flash animation shows the mode of action of oseltamivir Tamiflu 互联网档案馆的存檔 存档日期2005 10 23 pharmasquare org Replication of influenza virus 页面存档备份 存于互联网档案馆 mvm ed ac uk Bantia Shanta Arnold C Shane Parker Cynthia D Upshaw Ramanda Chand Pooran Anti influenza virus activity of peramivir in mice with single intramuscular injection Antiviral Research 1 January 2006 69 1 39 45 ISSN 0166 3542 PMID 16325932 doi 10 1016 j antiviral 2005 10 002 Ishizuka Hitoshi Yoshiba Satoshi Okabe Hiromi Yoshihara Kazutaka Clinical pharmacokinetics of laninamivir a novel long acting neuraminidase inhibitor after single and multiple inhaled doses of its prodrug CS 8958 in healthy male volunteers Journal of Clinical Pharmacology 1 November 2010 50 11 1319 1329 ISSN 1552 4604 PMID 20145259 doi 10 1177 0091270009356297 Jefferson Tom Jones Mark Doshi Peter Spencer Elizabeth A Onakpoya Igho Heneghan Carl J Oseltamivir for influenza in adults and children systematic review of clinical study reports and summary of regulatory comments BMJ 9 April 2014 348 g2545 2021 01 15 ISSN 1756 1833 PMC 3981975 nbsp PMID 24811411 doi 10 1136 bmj g2545 原始内容存档于2019 10 31 Hsu Jonathan Santesso Nancy Mustafa Reem Brozek Jan Chen Yao Long Hopkins Jessica P Cheung Adrienne Hovhannisyan Gayane Ivanova Liudmila Flottorp Signe A Saeterdal Ingvil Wong Arthur D Tian Jinhui Uyeki Timothy M Akl Elie A Alonso Coello Pablo Smaill Fiona Schunemann Holger J Antivirals for treatment of influenza a systematic review and meta analysis of observational studies Annals of Internal Medicine 3 April 2012 156 7 512 524 ISSN 1539 3704 PMC 6679687 nbsp PMID 22371849 doi 10 7326 0003 4819 156 7 201204030 00411 Heneghan Carl J Onakpoya Igho Thompson Matthew Spencer Elizabeth A Jones Mark Jefferson Tom Zanamivir for influenza in adults and children systematic review of clinical study reports and summary of regulatory comments BMJ 9 April 2014 348 g2547 2021 01 15 ISSN 1756 1833 PMC 3981976 nbsp PMID 24811412 doi 10 1136 bmj g2547 原始内容存档于2021 03 23 Louie Janice K Acosta Meileen Jamieson Denise J Honein Margaret A Severe 2009 H1N1 Influenza in Pregnant and Postpartum Women in California New England Journal of Medicine 2010 362 1 27 35 PMID 20032319 doi 10 1056 nejmoa0910444 Jain Seema Kamimoto Laurie Bramley Anna M Schmitz Ann M Benoit Stephen R Louie Janice Sugerman David E Druckenmiller Jean K Ritger Kathleen A Chugh Rashmi Jasuja Supriya Deutscher Meredith Chen Sanny Walker John D Duchin Jeffrey S Lett Susan Soliva Susan Wells Eden V Swerdlow David Uyeki Timothy M Fiore Anthony E Olsen Sonja J Fry Alicia M Bridges Carolyn B Finelli Lyn Hospitalized Patients with 2009 H1N1 Influenza in the United States April June 2009 New England Journal of Medicine 12 November 2009 361 20 1935 1944 CiteSeerX 10 1 1 183 7888 nbsp ISSN 0028 4793 PMID 19815859 doi 10 1056 NEJMoa0906695 Dominguez Cherit Guillermo Lapinsky Stephen E Macias Alejandro E Pinto Ruxandra Espinosa Perez Lourdes de la Torre Alethse Poblano Morales Manuel Baltazar Torres Jose A Bautista Edgar Martinez Abril Martinez Marco A Rivero Eduardo Valdez Rafael Ruiz Palacios Guillermo Hernandez Martin Stewart Thomas E Fowler Robert A Critically Ill patients with 2009 influenza A H1N1 in Mexico JAMA 4 November 2009 302 17 1880 1887 ISSN 1538 3598 PMID 19822626 doi 10 1001 jama 2009 1536 nbsp Zarychanski R Stuart T L Kumar A Doucette S Elliott L Kettner J Plummer F Correlates of severe disease in patients with 2009 pandemic influenza H1N1 virus infection Canadian Medical Association Journal 2010 182 3 257 264 ISSN 0820 3946 PMC 2826467 nbsp PMID 20093297 doi 10 1503 cmaj 091884 14 0 14 1 14 2 14 3 Sugaya Norio Widespread use of neuraminidase inhibitors in Japan Journal of Infection and Chemotherapy 1 October 2011 17 5 595 601 ISSN 1437 7780 PMID 21850418 doi 10 1007 s10156 011 0288 0 CDC Online Newsroom Have You Heard Archive 2014 Influenza A Variant Virus cdc gov 2021 01 15 原始内容存档于2017 01 18 Swaminathan K Dyason JC Maggioni A von Itzstein M Downard KM Binding of a natural anthocyanin inhibitor to influenza neuraminidase by mass spectrometry Anal Bioanal Chem 2013 405 20 6563 72 PMID 23748498 doi 10 1007 s00216 013 7068 x Kim Jang Hoon Ryu Young Bae Lee Woo Song Kim Young Ho Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome Bioorganic amp Medicinal Chemistry 2014 11 01 22 21 6047 6052 ISSN 1464 3391 PMID 25277281 doi 10 1016 j bmc 2014 09 004 nbsp 取自 https zh wikipedia org w index php title 神经氨酸酶抑制剂 amp oldid 76400098, 维基百科，wiki，书籍，书籍，图书馆，
