甘露庚酮糖

甘露庚酮糖（英語：Mannoheptulose）是一种庚糖，即有七个碳原子的单糖。它是己糖激酶的抑制剂，通过竞争性地与己糖激酶结合来阻断葡萄糖的磷酸化。结果是葡萄糖的降解被抑制。D-甘露庚酮糖最早在鳄梨中发现^[1]。

D-Mannoheptulose
IUPAC名 D-Manno-hept-2-ulose
识别
CAS号	3615-44-9
PubChem	12600
ChemSpider	12080
SMILES	O=C([C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CO
InChI	1S/C7H14O7/c8-1-3(10)5(12)7(14)6(13)4(11)2-9/h3,5-10,12-14H,1-2H2/t3-,5-,6-,7+/m1/s1
性质
化学式	C7H14O7
摩尔质量	210.18 g·mol^−1
密度	1.7 g cm^-3
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

有研究指出，甘露庚酮糖會抑制胰島素分泌^[2]。 This inhibition occurs because when mannoheptulose is present the glycolysis is inhibited (because there is no production of glucose-6-P) therefore no increase in ATP concentration which is required to close the KATP channel in the beta cells of the pancreas causing a diminution of calcium entry and insulin secretion.

参考文献

1. Dai, Nir; Schaffer, Arthur; Petreikov, Marina; Shahak, Yosepha; Giller, Yuri; Ratner, Kira; Levine, Alex; Granot, David. Overexpression of Arabidopsis Hexokinase in Tomato Plants Inhibits Growth, Reduces Photosynthesis, and Induces Rapid Senescence. The Plant Cell. 1999-07, 11 (7): 1253–1266 [2021-11-10]. ISSN 1040-4651. PMC 144264  . PMID 10402427. doi:10.1105/tpc.11.7.1253. （原始内容于2022-01-11） （英语）.  引文格式1维护：PMC格式 (link)
2. Lucke, C.; Kagan, A.; Adelman, N.; Glick, S. M. Effect of 2-Deoxy-D-Glucose and Mannoheptulose on the Insulin Response to Amino Acids in Rabbits. Diabetes. 1972-01-01, 21 (1): 1–5. ISSN 0012-1797. doi:10.2337/diab.21.1.1 （英语）.