^Hu, R. Codon optimization, expression, and characterization of recombinant lumbrokinase in goat milk. Protein Expression and Purification. 2004, 37 (1): 83–8. PMID 15294284. doi:10.1016/j.pep.2004.05.018.
^ 2.02.12.22.3Wang YH, Chen KM, Chiu PS, Lai SC, Su HH, Jan MS, Lin CW, Lu DY, Fu YT, Liao JM, Chang JT, Huang SS. Lumbrokinase attenuates myocardial ischemia-reperfusion injury by inhibiting TLR4 signaling. Journal of Molecular and Cellular Cardiology. 2016, 99: 113-122. doi:10.1016/j.yjmcc.2016.08.004.
^GangQiang Li, Kevin Yueju Wang, DaHui Li, Nan Wang, DeHu Liu. Cloning, Expression and Characterization of a Gene from Earthworm Eisenia fetida Encoding a Blood-Clot Dissolving Protein. PLoS One: e53110. doi:10.1371/journal.pone.0053110.
^Hisashi MIHARA, Hiroyuki SUMI, Tomoyuki YONETA, Hideaki MIZUMOTO, Ryuzo IKEDA, Masao SEIKI, Masugi MARUYAMA. A Novel Fibrinolytic Enzyme Extracted from the Earthworm, Lumbricus rubellus. The Japanese Journal of Physiology: 461-472. doi:10.2170/jjphysiol.41.461.
^Ge, T.; Sun, Z.; Fu, S.; Liang, G. Cloning of thrombolytic enzyme (lumbrokinase) from earthworm and its expression in the yeast. Protein Expression and Purification. 2005, 42 (1): 20–8. PMID 15927482. doi:10.1016/j.pep.2005.04.005.
^Edwin L.Cooper, M.Balamurugan. Unearthing a source of medicinal molecules. Drug Discovery Today. 2010, 15 (21-22): 966-972. doi:10.1016/j.drudis.2010.09.004.
十月 05, 2023
蚓激酶, 维基百科中的醫學内容仅供参考, 並不能視作專業意見, 如需獲取醫療幫助或意見, 请咨询专业人士, 詳見醫學聲明, lumbrokinase, 是一種纖溶酶, 大小介於25, 32kda之間, 可以多種途徑促進纖維蛋白的溶解, 除了具有纖溶酶活性外, 還可作為纖維蛋白溶酶原激活物以刺激纖溶酶的生成, 又可促進組織間其他纖維蛋白溶酶原激活物的活性, 最早於1991年在正蚓屬, 英语, lumbricus, 蚯蚓lumbricus, bimastus體內發現, 亦存在於赤子愛勝蚓, 粉正蚓, 英语, lumbr. 维基百科中的醫學内容仅供参考 並不能視作專業意見 如需獲取醫療幫助或意見 请咨询专业人士 詳見醫學聲明 蚓激酶 Lumbrokinase 是一種纖溶酶 1 註 1 大小介於25 32kDa之間 2 可以多種途徑促進纖維蛋白的溶解 除了具有纖溶酶活性外 還可作為纖維蛋白溶酶原激活物以刺激纖溶酶的生成 又可促進組織間其他纖維蛋白溶酶原激活物的活性 3 蚓激酶最早於1991年在正蚓屬 英语 Lumbricus 蚯蚓Lumbricus bimastus體內發現 2 4 亦存在於赤子愛勝蚓 粉正蚓 英语 Lumbricus rubellus 與等多種蚯蚓的體腔與消化道內 這種纖溶酶結構穩定 且在人體中可被小腸吸收 因而有作為抗血栓 英语 antithrombotic 藥物的潛力 5 且不同於鏈激酶等其他種專一性較低的抗血栓藥物 蚓激酶對纖維蛋白的專一性很高 只有纖維蛋白存在時才具有酵素活性 而較無造成纖溶亢進 英语 hyperfibrinolysis 導致大出血 英语 hemorrhage 之虞 2 6 蚓激酶已在臨床上被用於治療中風與其他心血管疾病 2 註釋 编辑 一種促進纖維蛋白凝塊分解的蛋白質 能產生纖溶作用 英语 fibrinolytic 參考資料 编辑 Hu R Codon optimization expression and characterization of recombinant lumbrokinase in goat milk Protein Expression and Purification 2004 37 1 83 8 PMID 15294284 doi 10 1016 j pep 2004 05 018 2 0 2 1 2 2 2 3 Wang YH Chen KM Chiu PS Lai SC Su HH Jan MS Lin CW Lu DY Fu YT Liao JM Chang JT Huang SS Lumbrokinase attenuates myocardial ischemia reperfusion injury by inhibiting TLR4 signaling Journal of Molecular and Cellular Cardiology 2016 99 113 122 doi 10 1016 j yjmcc 2016 08 004 GangQiang Li Kevin Yueju Wang DaHui Li Nan Wang DeHu Liu Cloning Expression and Characterization of a Gene from Earthworm Eisenia fetida Encoding a Blood Clot Dissolving Protein PLoS One e53110 doi 10 1371 journal pone 0053110 Hisashi MIHARA Hiroyuki SUMI Tomoyuki YONETA Hideaki MIZUMOTO Ryuzo IKEDA Masao SEIKI Masugi MARUYAMA A Novel Fibrinolytic Enzyme Extracted from the Earthworm Lumbricus rubellus The Japanese Journal of Physiology 461 472 doi 10 2170 jjphysiol 41 461 Ge T Sun Z Fu S Liang G Cloning of thrombolytic enzyme lumbrokinase from earthworm and its expression in the yeast Protein Expression and Purification 2005 42 1 20 8 PMID 15927482 doi 10 1016 j pep 2005 04 005 Edwin L Cooper M Balamurugan Unearthing a source of medicinal molecules Drug Discovery Today 2010 15 21 22 966 972 doi 10 1016 j drudis 2010 09 004 取自 https zh wikipedia org w index php title 蚓激酶 amp oldid 77465544, 维基百科，wiki，书籍，书籍，图书馆，
