^Salzman, NH; Underwood, MA; Bevins, CL. Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa.. Seminars in immunology. 2007-04, 19 (2): 70–83 [2019-11-18]. PMID 17485224. doi:10.1016/j.smim.2007.04.002.
^Wilson, CL; Ouellette, AJ; Satchell, DP; Ayabe, T; López-Boado, YS; Stratman, JL; Hultgren, SJ; Matrisian, LM; Parks, WC. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.. Science (New York, N.Y.). 1999-10-01, 286 (5437): 113–7 [2019-11-18]. PMID 10506557. doi:10.1126/science.286.5437.113.
^Ayabe, T; Satchell, DP; Wilson, CL; Parks, WC; Selsted, ME; Ouellette, AJ. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria.. Nature immunology. 2000-08, 1 (2): 113–8 [2019-11-18]. PMID 11248802. doi:10.1038/77783.
^Sato, Toshiro; van Es, Johan H.; Snippert, Hugo J.; Stange, Daniel E.; Vries, Robert G.; van den Born, Maaike; Barker, Nick; Shroyer, Noah F.; van de Wetering, Marc; Clevers, Hans. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 2010-11-28, 469 (7330): 415–418 [2019-11-18]. doi:10.1038/nature09637. （原始内容于2021-03-08）.
^ 6.06.1Nakamura, Kiminori; Ayabe, Tokiyoshi. Paneth cells and stem cells in the intestinal stem cell niche and their association with inflammatory bowel disease. Inflammation and Regeneration. 2012, 32 (2): 053–060. doi:10.2492/inflammregen.32.053.
^Sandow, MJ; Whitehead, R. The Paneth cell.. Gut. 1979-05, 20 (5): 420–31 [2019-11-18]. PMID 381125. doi:10.1136/gut.20.5.420.
十月 21, 2023
潘氏细胞, 潘氏細胞, 或稱帕內特細胞, paneth, cells, 是起源於腸隱窩乾細胞的小腸腺特徵性細胞, 與隱窩乾細胞間隔排列於小腸腺的底部, 並且遍布於整個小腸, 胞體呈錐體形, 胞質頂部的粗大嗜酸性顆粒的主要成分為防禦素, 溶菌酶, spla2, 血管生成因子和reg3, pcs幫助宿主抵禦腸道致病微生物的侵犯, 其功能性類似於嗜中性球, 並且與於小腸的先天性免疫相關, 當暴露於細菌或細菌抗原時, 潘氏細胞會分泌防禦素等抗菌分子到小腸管腔的絨毛, 幫助維持胃腸道屏障, 人體的潘氏細胞功能, 编辑潘氏細胞. 潘氏細胞 或稱帕內特細胞 Paneth cells PCs 是起源於腸隱窩乾細胞的小腸腺特徵性細胞 與隱窩乾細胞間隔排列於小腸腺的底部 並且遍布於整個小腸 胞體呈錐體形 胞質頂部的粗大嗜酸性顆粒的主要成分為防禦素 80 1 溶菌酶 SPLA2 血管生成因子和Reg3 g PCs幫助宿主抵禦腸道致病微生物的侵犯 其功能性類似於嗜中性球 並且與於小腸的先天性免疫相關 當暴露於細菌或細菌抗原時 潘氏細胞會分泌防禦素等抗菌分子到小腸管腔的絨毛 2 3 幫助維持胃腸道屏障 人體的潘氏細胞功能 编辑潘氏細胞能夠分泌腸抗菌肽 防禦素 溶菌霉素 磷脂酶和C 型凝集素等多種物質 4 有助潘氏細胞在維持腸道先天性免疫 腸道抗菌抗炎及腸上皮組織完整性等方面中發揮作用 潘氏細胞和Lgr 5 英语 LGR5 陽性腸幹細胞會共同構成幹細胞巢 5 潘氏細胞可提供一些維護乾性特徵的關鍵受體或配體 如表皮生長因子 DLL4 英语 DLL4 WNT3 英语 WNT3 等 從而激活相應的細胞信號通路 繼而維持Lgr 5陽性腸幹細胞的正常細胞功能 6 潘氏細胞結構和功能的異常已被證實和腸道疾病存在密切關係 6 發現過程 编辑1872年 德國解剖學家Schwalbe首先在小腸隱窩底部觀察到一種錐體形細胞 7 1888年 奧地利醫師約瑟夫 帕內特 英语 Joseph Paneth 對這種細胞進行進一步的觀察和描述 該細胞被命名為潘氏細胞 参考資料 编辑 Salzman NH Underwood MA Bevins CL Paneth cells defensins and the commensal microbiota a hypothesis on intimate interplay at the intestinal mucosa Seminars in immunology 2007 04 19 2 70 83 2019 11 18 PMID 17485224 doi 10 1016 j smim 2007 04 002 Wilson CL Ouellette AJ Satchell DP Ayabe T Lopez Boado YS Stratman JL Hultgren SJ Matrisian LM Parks WC Regulation of intestinal alpha defensin activation by the metalloproteinase matrilysin in innate host defense Science New York N Y 1999 10 01 286 5437 113 7 2019 11 18 PMID 10506557 doi 10 1126 science 286 5437 113 Ayabe T Satchell DP Wilson CL Parks WC Selsted ME Ouellette AJ Secretion of microbicidal alpha defensins by intestinal Paneth cells in response to bacteria Nature immunology 2000 08 1 2 113 8 2019 11 18 PMID 11248802 doi 10 1038 77783 Bevins CL Salzman NH Paneth cells antimicrobial peptides and maintenance of intestinal homeostasis Nature reviews Microbiology 2011 05 9 5 356 68 2019 11 18 PMID 21423246 doi 10 1038 nrmicro2546 Sato Toshiro van Es Johan H Snippert Hugo J Stange Daniel E Vries Robert G van den Born Maaike Barker Nick Shroyer Noah F van de Wetering Marc Clevers Hans Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts Nature 2010 11 28 469 7330 415 418 2019 11 18 doi 10 1038 nature09637 原始内容存档于2021 03 08 6 0 6 1 Nakamura Kiminori Ayabe Tokiyoshi Paneth cells and stem cells in the intestinal stem cell niche and their association with inflammatory bowel disease Inflammation and Regeneration 2012 32 2 053 060 doi 10 2492 inflammregen 32 053 Sandow MJ Whitehead R The Paneth cell Gut 1979 05 20 5 420 31 2019 11 18 PMID 381125 doi 10 1136 gut 20 5 420 取自 https zh wikipedia org w index php title 潘氏细胞 amp oldid 74254295, 维基百科，wiki，书籍，书籍，图书馆，
