串联重复可以作为确定个体的遗传特征的一种描述模式，在确定亲子关系中非常有用。短串联重复序列可用于一些系谱DNA检验（英语：genealogical DNA test）。
DNA is examined from microsatellites within the chromosomal DNA. Minisatellite is another way of saying special regions of the loci. Polymerase chain reaction (or PCR) is performed on the minisatellite areas. The PCR must be performed on each organism being tested. The amplified material is then run through electrophoresis. By checking the percentage of bands that match, parentage is determined.
Polymorphic tandem repeats (alias VNTRs) are also present in microorganisms and can be used to trace the origin of an outbreak. The corresponding assay in which a collection of VNTRs is typed to characterize a strain is most often called MLVA (Multiple Loci VNTR Analysis).
In the field of Computer Science, tandem repeats in strings (e.g., DNA sequences) can be efficiently detected using suffix trees or suffix arrays.
Studies in 2004 linked the unusual genetic plasticity of dogs to mutations in tandem repeats.[5]
^Jorda J, Xue B, Uversky VN, Kajava AV. Protein tandem repeats - the more perfect, the less structured. The FEBS Journal. June 2010, 277 (12): 2673–82. PMC 2928880. PMID 20553501. doi:10.1111/j.1742-464X.2010.07684.x.
^Oki E, Oda S, Maehara Y, Sugimachi K. Mutated gene-specific phenotypes of dinucleotide repeat instability in human colorectal carcinoma cell lines deficient in DNA mismatch repair. Oncogene. March 1999, 18 (12): 2143–7. PMID 10321739. doi:10.1038/sj.onc.1202583.
^Pennisi E. Genetics. A ruff theory of evolution: gene stutters drive dog shape. Science. December 2004, 306 (5705): 2172. PMID 15618495. doi:10.1126/science.306.5705.2172.
外部链接
例子：
VNTRs（页面存档备份，存于互联网档案馆） - info and animated example
Phobos - a tandem repeat search tool for perfect and imperfect repeats - the maximum pattern size depends only on computational power（页面存档备份，存于互联网档案馆）
- an ultra fast and memory efficient open-source tandem repeats finder implementation.
二月 04, 2023
串联重复, 此條目需要精通或熟悉相关主题的编者参与及协助编辑, 2014年12月22日, 請邀請適合的人士改善本条目, 更多的細節與詳情請參见討論頁, 英語, tandem, repeats, 是指dna中的一个或多个核苷酸前后相连接的重复, 一个例子, attcgattcgattcg其中的attcg在这里重复了三次, 几种蛋白质结构域也是由的氨基酸序列产生, 如犰狳重复, 英语, armadillo, repeats, 但很少有出现在体内的蛋白质中, 多数为人工设计的蛋白, 目录, 术语, 应用, 参考文献, 外. 此條目需要精通或熟悉相关主题的编者参与及协助编辑 2014年12月22日 請邀請適合的人士改善本条目 更多的細節與詳情請參见討論頁 串联重复 英語 Tandem repeats 是指DNA中的一个或多个核苷酸前后相连接的重复 1 一个例子 ATTCGATTCGATTCG其中的ATTCG在这里重复了三次 几种蛋白质结构域也是由串联重复的氨基酸序列产生 如犰狳重复 英语 Armadillo repeats 但很少有串联重复出现在体内的蛋白质中 多数为人工设计的蛋白 2 目录 1 术语 2 应用 3 参考文献 4 外部链接术语 编辑当重复核苷酸数在10到60之间时 被称为小衛星 低于10则被称为短串联重复或微衛星 當重复核苷酸只有两个的時候 称为 双核苷酸重复 如 ACACACAC 遗传性非息肉病性结直肠癌 英语 Hereditary nonpolyposis colorectal cancer 的微卫星不稳定性 英语 microsatellite instability 常为这种类型 3 当重复核苷酸有三个时 称为 三核苷酸重复 如 CAGCAGCAGCAG 在这一区域的异常常导致三核苷酸重复疾病 英语 Trinucleotide repeat disorder 当重复单元的拷贝数在人群中存在不同时 被称为可变数目串联重复序列 VNTR 4 应用 编辑串联重复可以作为确定个体的遗传特征的一种描述模式 在确定亲子关系中非常有用 短串联重复序列可用于一些系谱DNA检验 英语 genealogical DNA test DNA is examined from microsatellites within the chromosomal DNA Minisatellite is another way of saying special regions of the loci Polymerase chain reaction or PCR is performed on the minisatellite areas The PCR must be performed on each organism being tested The amplified material is then run through electrophoresis By checking the percentage of bands that match parentage is determined Polymorphic tandem repeats alias VNTRs are also present in microorganisms and can be used to trace the origin of an outbreak The corresponding assay in which a collection of VNTRs is typed to characterize a strain is most often called MLVA Multiple Loci VNTR Analysis In the field of Computer Science tandem repeats in strings e g DNA sequences can be efficiently detected using suffix trees or suffix arrays Studies in 2004 linked the unusual genetic plasticity of dogs to mutations in tandem repeats 5 参考文献 编辑 醫學主題詞表 MeSH Tandem Repeat Jorda J Xue B Uversky VN Kajava AV Protein tandem repeats the more perfect the less structured The FEBS Journal June 2010 277 12 2673 82 PMC 2928880 PMID 20553501 doi 10 1111 j 1742 464X 2010 07684 x Oki E Oda S Maehara Y Sugimachi K Mutated gene specific phenotypes of dinucleotide repeat instability in human colorectal carcinoma cell lines deficient in DNA mismatch repair Oncogene March 1999 18 12 2143 7 PMID 10321739 doi 10 1038 sj onc 1202583 醫學主題詞表 MeSH Variable Number of Tandem Repeats Pennisi E Genetics A ruff theory of evolution gene stutters drive dog shape Science December 2004 306 5705 2172 PMID 15618495 doi 10 1126 science 306 5705 2172 外部链接 编辑例子 VNTRs 页面存档备份 存于互联网档案馆 info and animated example 数据库 The Microorganisms Tandem Repeats Database Short Tandem Repeats Database 页面存档备份 存于互联网档案馆 搜索工具 Tandem Repeats Finder 页面存档备份 存于互联网档案馆 Mreps 页面存档备份 存于互联网档案馆 STAR 页面存档备份 存于互联网档案馆 TRED Tandem Repeats over the Edit Distance TandemSWAN Microsatellite repeats finder JSTRING Java Search for Tandem Repeats in genomes Phobos a tandem repeat search tool for perfect and imperfect repeats the maximum pattern size depends only on computational power 页面存档备份 存于互联网档案馆 UGENE an ultra fast and memory efficient open source tandem repeats finder implementation 取自 https zh wikipedia org w index php title 串联重复 amp oldid 72553282, 维基百科，wiki，书籍，书籍，图书馆，
