fbpx
维基百科

α螺旋

α螺旋(alpha helix (α-helix);Pauling–Corey–Branson α-helix;3.613-helix)是蛋白质二级结构。它和β折叠因具有重复的Φ和Ψ值被统称为规则二级结构(Cα-N夹角和Cα-C夹角)。

丙氨酸形成的α螺旋结构的三維面观

α螺旋一般是右手螺旋。在α螺旋中,平均每个螺旋周期包含3.6个氨基酸残基,这些残基侧链伸向外侧。同一肽链上的每个残基的酰胺氢原子和位于它后面的第4个残基上的羰基氧原子之间形成氢键。其中的H-O键长2.8Å。这种氢键大致与螺旋轴平行。一条多肽链呈α螺旋构象的原因是所有肽键上的酰胺氢和羰基氧之间形成的链内氢键。在水环境中,肽键上的酰胺氢和羰基氧既能形成分子内(α螺旋内)氢键,也能与水分子形成氢键。如果后者发生,多肽链呈现类似变性蛋白质那样的伸展构象。非极性溶剂环境对于氢键形成没有影响,因此更可能促进α螺旋的形成。

α螺旋中,氨基酸的R基团指向外侧和下侧,以避免与多肽链的主干部分之间的位阻影响。α螺旋的核心部分紧密结合,原子之间以范德华力联系在一起。

因为其特殊的环状R基团,脯氨酸一般不出现在α螺旋中部,而经常出现在α螺旋的开始处。

资料来源

  • Donald Voet, Judith G. Voet, Charlotte Pratt. Fundamentals Of Biochemistry, upgrade edition

延伸閲讀

  • Tooze J, Brändén CI. Introduction to protein structure. New York: Garland Pub. 1999. ISBN 0-8153-2304-2. .
  • Eisenberg D. The discovery of the alpha-helix and beta-sheet, the principal structural features of proteins. Proceedings of the National Academy of Sciences of the United States of America. September 2003, 100 (20): 11207–10. Bibcode:2003PNAS..10011207E. PMC 208735 . PMID 12966187. doi:10.1073/pnas.2034522100. 
  • Astbury WT, Woods HJ. The Molecular Weights of Proteins. Nature. 1931, 127 (3209): 663–665. Bibcode:1931Natur.127..663A. doi:10.1038/127663b0. 
  • Astbury WT, Street A. X-ray studies of the structures of hair, wool and related fibres. I. General. Trans. R. Soc. Lond. 1931, A230: 75–101. Bibcode:1932RSPTA.230...75A. doi:10.1098/rsta.1932.0003. 
  • Astbury WT. Some Problems in the X-ray Analysis of the Structure of Animal Hairs and Other Protein Fibers. Trans. Faraday Soc. 1933, 29 (140): 193–211. doi:10.1039/tf9332900193. 
  • Astbury WT, Woods HJ. X-ray studies of the structures of hair, wool and related fibres. II. The molecular structure and elastic properties of hair keratin. Philosophical Transactions of the Royal Society of London Series A. 1934, 232 (707–720): 333–394. Bibcode:1934RSPTA.232..333A. doi:10.1098/rsta.1934.0010. 
  • Astbury WT, Sisson WA. X-ray studies of the structures of hair, wool and related fibres. III. The configuration of the keratin molecule and its orientation in the biological cell. Proceedings of the Royal Society. 1935, A150 (871): 533–551. Bibcode:1935RSPSA.150..533A. doi:10.1098/rspa.1935.0121. 
  • Sugeta H, Miyazawa T. General Method for Calculating Helical Parameters of Polymer Chains from Bond Lengths, Bond Angles, and Internal-Rotation Angles. Biopolymers. 1967, 5 (7): 673–679. doi:10.1002/bip.1967.360050708. 
  • Wada A. The alpha-helix as an electric macro-dipole. Advances in Biophysics. 1976: 1–63. PMID 797240. 
  • Chothia C, Levitt M, Richardson D. Structure of proteins: packing of alpha-helices and pleated sheets. Proceedings of the National Academy of Sciences of the United States of America. October 1977, 74 (10): 4130–4. Bibcode:1977PNAS...74.4130C. PMC 431889 . PMID 270659. doi:10.1073/pnas.74.10.4130. 
  • Chothia C, Levitt M, Richardson D. Helix to helix packing in proteins. Journal of Molecular Biology. January 1981, 145 (1): 215–50. PMID 7265198. doi:10.1016/0022-2836(81)90341-7. 
  • Hol WG. The role of the alpha-helix dipole in protein function and structure. Progress in Biophysics and Molecular Biology. 1985, 45 (3): 149–95. PMID 3892583. doi:10.1016/0079-6107(85)90001-X. 
  • Barlow DJ, Thornton JM. Helix geometry in proteins. Journal of Molecular Biology. June 1988, 201 (3): 601–19. PMID 3418712. doi:10.1016/0022-2836(88)90641-9. 
  • Murzin AG, Finkelstein AV. General architecture of the alpha-helical globule. Journal of Molecular Biology. December 1988, 204 (3): 749–69. PMID 3225849. doi:10.1016/0022-2836(88)90366-X. 

外部連結

  • NetSurfP ver. 1.1 - Protein Surface Accessibility and Secondary Structure Predictions (页面存档备份,存于互联网档案馆
  • α-helix rotational angle calculator (页面存档备份,存于互联网档案馆
  • Artist Julie Newdoll's website (页面存档备份,存于互联网档案馆
  • Artist Julian Voss-Andreae's website (页面存档备份,存于互联网档案馆

template:Spirals英语template:Spirals

α螺旋, 此條目翻譯品質不佳, 翻譯者可能不熟悉中文或原文語言, 也可能使用了機器翻譯, 請協助翻譯本條目或重新編寫, 并注意避免翻译腔的问题, 明顯拙劣的翻譯請改掛, href, template, html, class, redirect, title, template, href, wikipedia, html, class, redirect, title, wikipedia, 提交刪除, alpha, helix, helix, pauling, corey, branson, helix, he. 此條目翻譯品質不佳 翻譯者可能不熟悉中文或原文語言 也可能使用了機器翻譯 請協助翻譯本條目或重新編寫 并注意避免翻译腔的问题 明顯拙劣的翻譯請改掛 a href Template D html class mw redirect title Template D d a a href Wikipedia CSD html G13 class mw redirect title Wikipedia CSD G13 a 提交刪除 a螺旋 alpha helix a helix Pauling Corey Branson a helix 3 613 helix 是蛋白质的二级结构 它和b折叠因具有重复的F和PS值被统称为规则二级结构 Ca N夹角和Ca C夹角 聚丙氨酸形成的a螺旋结构的三維面观 a螺旋一般是右手螺旋 在a螺旋中 平均每个螺旋周期包含3 6个氨基酸残基 这些残基侧链伸向外侧 同一肽链上的每个残基的酰胺氢原子和位于它后面的第4个残基上的羰基氧原子之间形成氢键 其中的H O键长2 8A 这种氢键大致与螺旋轴平行 一条多肽链呈a螺旋构象的原因是所有肽键上的酰胺氢和羰基氧之间形成的链内氢键 在水环境中 肽键上的酰胺氢和羰基氧既能形成分子内 a螺旋内 氢键 也能与水分子形成氢键 如果后者发生 多肽链呈现类似变性蛋白质那样的伸展构象 非极性溶剂环境对于氢键形成没有影响 因此更可能促进a螺旋的形成 a螺旋中 氨基酸的R基团指向外侧和下侧 以避免与多肽链的主干部分之间的位阻影响 a螺旋的核心部分紧密结合 原子之间以范德华力联系在一起 因为其特殊的环状R基团 脯氨酸一般不出现在a螺旋中部 而经常出现在a螺旋的开始处 资料来源 编辑Donald Voet Judith G Voet Charlotte Pratt Fundamentals Of Biochemistry upgrade edition延伸閲讀 编辑Tooze J Branden CI Introduction to protein structure New York Garland Pub 1999 ISBN 0 8153 2304 2 Eisenberg D The discovery of the alpha helix and beta sheet the principal structural features of proteins Proceedings of the National Academy of Sciences of the United States of America September 2003 100 20 11207 10 Bibcode 2003PNAS 10011207E PMC 208735 PMID 12966187 doi 10 1073 pnas 2034522100 Astbury WT Woods HJ The Molecular Weights of Proteins Nature 1931 127 3209 663 665 Bibcode 1931Natur 127 663A doi 10 1038 127663b0 Astbury WT Street A X ray studies of the structures of hair wool and related fibres I General Trans R Soc Lond 1931 A230 75 101 Bibcode 1932RSPTA 230 75A doi 10 1098 rsta 1932 0003 Astbury WT Some Problems in the X ray Analysis of the Structure of Animal Hairs and Other Protein Fibers Trans Faraday Soc 1933 29 140 193 211 doi 10 1039 tf9332900193 Astbury WT Woods HJ X ray studies of the structures of hair wool and related fibres II The molecular structure and elastic properties of hair keratin Philosophical Transactions of the Royal Society of London Series A 1934 232 707 720 333 394 Bibcode 1934RSPTA 232 333A doi 10 1098 rsta 1934 0010 Astbury WT Sisson WA X ray studies of the structures of hair wool and related fibres III The configuration of the keratin molecule and its orientation in the biological cell Proceedings of the Royal Society 1935 A150 871 533 551 Bibcode 1935RSPSA 150 533A doi 10 1098 rspa 1935 0121 Sugeta H Miyazawa T General Method for Calculating Helical Parameters of Polymer Chains from Bond Lengths Bond Angles and Internal Rotation Angles Biopolymers 1967 5 7 673 679 doi 10 1002 bip 1967 360050708 Wada A The alpha helix as an electric macro dipole Advances in Biophysics 1976 1 63 PMID 797240 Chothia C Levitt M Richardson D Structure of proteins packing of alpha helices and pleated sheets Proceedings of the National Academy of Sciences of the United States of America October 1977 74 10 4130 4 Bibcode 1977PNAS 74 4130C PMC 431889 PMID 270659 doi 10 1073 pnas 74 10 4130 Chothia C Levitt M Richardson D Helix to helix packing in proteins Journal of Molecular Biology January 1981 145 1 215 50 PMID 7265198 doi 10 1016 0022 2836 81 90341 7 Hol WG The role of the alpha helix dipole in protein function and structure Progress in Biophysics and Molecular Biology 1985 45 3 149 95 PMID 3892583 doi 10 1016 0079 6107 85 90001 X Barlow DJ Thornton JM Helix geometry in proteins Journal of Molecular Biology June 1988 201 3 601 19 PMID 3418712 doi 10 1016 0022 2836 88 90641 9 Murzin AG Finkelstein AV General architecture of the alpha helical globule Journal of Molecular Biology December 1988 204 3 749 69 PMID 3225849 doi 10 1016 0022 2836 88 90366 X 外部連結 编辑NetSurfP ver 1 1 Protein Surface Accessibility and Secondary Structure Predictions 页面存档备份 存于互联网档案馆 a helix rotational angle calculator 页面存档备份 存于互联网档案馆 Artist Julie Newdoll s website 页面存档备份 存于互联网档案馆 Artist Julian Voss Andreae s website 页面存档备份 存于互联网档案馆 template Spirals 英语 template Spirals 取自 https zh wikipedia org w index php title A螺旋 amp oldid 75590351, 维基百科,wiki,书籍,书籍,图书馆,

文章

,阅读,下载,免费,免费下载,mp3,视频,mp4,3gp, jpg,jpeg,gif,png,图片,音乐,歌曲,电影,书籍,游戏,游戏。