Structure of a G-quadruplex. Left: a G-tetrad. Right: an intramolecular G-quadruplex3D Structure of the intramolecular human telomeric G-quadruplex in potassium solution (PDB ID 2HY9). The backbone is represented by a tube. The center of this structure contains three layers of G-tetrads. The hydrogen bonds in these layers are represented by blue dashed lines.
^Campbell, Nancy H.; Neidle, Stephen. Chapter 4. G-Quadruplexes and Metal Ions. Astrid Sigel, Helmut Sigel and Roland K. O. Sigel (编). Interplay between Metal Ions and Nucleic Acids. Metal Ions in Life Sciences 10. Springer. 2012: 119–1134. doi:10.1007/978-94-007-2172-2_4.
^Bochman, Matthew L.; Paeschke, Katrin; Zakian, Virginia A. DNA secondary structures: stability and function of G-quadruplex structures. Nature Reviews Genetics 13. Nature Publishing Group. 2012: 770–780. doi:10.1038/nrg3296.
參考文獻编辑
Jiangtao Ren, Jiahai Wang* , Lei Han, Erkang Wang*, Jin Wang*. Kinetically grafting G-qaudruplex onto DNA nanostructure as structure and function encoding via DNA machine. Chem. Commun. 2011, 47: 10563–10565 [2015-06-19]. （原始内容于2015-04-20）.
Johnson JE, Smith JS, Kozak ML, Johnson FB. In vivo veritas: using yeast to probe the biological functions of G-quadruplexes. Biochimie. 2008, 90 (8): 1250–1263 [2015-06-19]. PMC 2585026. PMID 18331848. doi:10.1016/j.biochi.2008.02.013. （原始内容于2019-02-07）.
Huppert JL and Balasubramanian S. Prevalence of quadruplexes in the human genome. NAR. 2005, 33 (9): 2908–2916 [2007-06-20]. PMC 1140081. PMID 15914667. doi:10.1093/nar/gki609. （原始内容于2007-05-06）.
Todd AK, Johnston M, Neidle S. Highly prevalent putative quadruplex sequence motifs in human DNA. NAR. 2005, 33 (9): 2901–2907 [2007-06-20]. PMC 1140077. PMID 15914666. doi:10.1093/nar/gki553. （原始内容于2007-05-06）.
Siddiqui-Jain A, Grand CL, Bearss DJ, Hurley LH. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. PNAS. 2002, 99 (18): 11593–8 [2007-06-20]. PMC 129314. PMID 12195017. doi:10.1073/pnas.182256799. （原始内容于2007-10-01）.
Rawal P, Kummarasetti VB, Ravindran J, Kumar N, Halder K, Sharma R, Mukerji M, Das SK, Chowdhury S. Genome-wide prediction of G4 DNA as regulatory motifs: Role in Escherichia coli global regulation. Genome Res. 2006, 16 (5): 644–55 [2007-06-20]. PMC 1457047. PMID 16651665. doi:10.1101/gr.4508806. （原始内容于2007-09-12）.
Xu Hou, Wei Guo, Fan Xia, Fu-Qiang Nie, Hua Dong, Ye Tian, Liping Wen, Lin Wang, Liuxuan Cao, Yang Yang, Jianming Xue, Yanlin Song, Yugang Wang, Dongsheng Liu, and Lei Jiang. . J. Am. Chem. Soc. 2009, 131 (22): 7800–7805 [2015-06-19]. PMID 19435350. doi:10.1021/ja901574c. （原始内容存档于2022-03-15）.
Neidle & Balasubramanian (编). . 2006 [2007-06-20]. ISBN 0-85404-374-8. （原始内容存档于2007-09-30）.
外部連結编辑
Nanopore and Aptamer Biosensor group（页面存档备份，存于互联网档案馆）{NAB group}
四聯體網站编辑
– the European network of G-quadruplex community: From first principles to applications
– a website to serve the quadruplex community
G-Quadruplex World（页面存档备份，存于互联网档案馆） – a website to discuss publications and other information of interest to those working in the field of G-quadruplexes
– downloadable data on predicted G-quadruplexes
– a database listing potential G-quadruplex regulated genes
GRSDB（页面存档备份，存于互联网档案馆）- a database of G-quadruplexes near RNA processing sites.
- a web server to predict G-quadruplex forming motifs and other non-B DNA forming motifs from users' DNA sequences.
預測G-四聯體的工具编辑
Quadparser: Downloadable program for finding putative quadruplex-forming sequences（页面存档备份，存于互联网档案馆） from Balasubramanian's group.
QGRS Mapper: a web-based application for predicting G-quadruplexes in nucleotide sequences and NCBI genes（页面存档备份，存于互联网档案馆） from Bagga's group.
Quadfinder: Tool for Prediction and Analysis of G Quadruplex Motifs in DNA/RNA Sequences from Maiti's group, IGIB, Delhi, India[永久失效連結]
十月 20, 2023
四聯體, 英語, quadruplex, tetrads或g4, 是一種由富含鳥嘌呤的核酸序列所構成的四股型態, 含有經由胡斯坦, hoogsteen, 氫鍵維持穩定, 並由鳥嘌呤以正方形方式排列而成的結構, 在方形中央有一個單價陽離子, 通常是鉀, 這種結構可見於dna, 鎖核酸, 與pna, 肽核酸, 根據形成四聯體的各股的方向, 可能有分子內, intramolecular, 雙分子, bimolecular, 或四分子, tetramolecular, 等不同類型, 在四聯體的結構中, 我們可以根據四股的方. G 四聯體 英語 G quadruplex G tetrads或G4 DNA 是一種由富含鳥嘌呤的核酸序列所構成的四股型態 含有經由胡斯坦 Hoogsteen 氫鍵維持穩定 並由鳥嘌呤以正方形方式排列而成的結構 在方形中央有一個單價陽離子 通常是鉀 1 這種結構可見於DNA RNA LNA 鎖核酸 與PNA 肽核酸 根據形成四聯體的各股的方向 可能有分子內 intramolecular 雙分子 bimolecular 或四分子 tetramolecular 等不同類型 2 在四聯體的結構中 我們可以根據四股的方向 將結構分為平行和反平行 英语 Antiparallel biochemistry Structure of a G quadruplex Left a G tetrad Right an intramolecular G quadruplex3D Structure of the intramolecular human telomeric G quadruplex in potassium solution PDB ID 2HY9 The backbone is represented by a tube The center of this structure contains three layers of G tetrads The hydrogen bonds in these layers are represented by blue dashed lines 目录 1 註釋 2 參考文獻 3 外部連結 3 1 四聯體網站 3 2 預測G 四聯體的工具註釋 编辑 Campbell Nancy H Neidle Stephen Chapter 4 G Quadruplexes and Metal Ions Astrid Sigel Helmut Sigel and Roland K O Sigel 编 Interplay between Metal Ions and Nucleic Acids Metal Ions in Life Sciences 10 Springer 2012 119 1134 doi 10 1007 978 94 007 2172 2 4 Bochman Matthew L Paeschke Katrin Zakian Virginia A DNA secondary structures stability and function of G quadruplex structures Nature Reviews Genetics 13 Nature Publishing Group 2012 770 780 doi 10 1038 nrg3296 參考文獻 编辑Jiangtao Ren Jiahai Wang Lei Han Erkang Wang Jin Wang Kinetically grafting G qaudruplex onto DNA nanostructure as structure and function encoding via DNA machine Chem Commun 2011 47 10563 10565 2015 06 19 原始内容存档于2015 04 20 Johnson JE Smith JS Kozak ML Johnson FB In vivo veritas using yeast to probe the biological functions of G quadruplexes Biochimie 2008 90 8 1250 1263 2015 06 19 PMC 2585026 nbsp PMID 18331848 doi 10 1016 j biochi 2008 02 013 原始内容存档于2019 02 07 Huppert JL and Balasubramanian S Prevalence of quadruplexes in the human genome NAR 2005 33 9 2908 2916 2007 06 20 PMC 1140081 nbsp PMID 15914667 doi 10 1093 nar gki609 原始内容存档于2007 05 06 Todd AK Johnston M Neidle S Highly prevalent putative quadruplex sequence motifs in human DNA NAR 2005 33 9 2901 2907 2007 06 20 PMC 1140077 nbsp PMID 15914666 doi 10 1093 nar gki553 原始内容存档于2007 05 06 Burge S Parkinson GN Hazel P Todd AK Neidle S Quadruplex DNA sequence topology and structure NAR 2006 34 19 5402 5415 2007 06 20 PMC 1636468 nbsp PMID 17012276 doi 10 1093 nar gkl655 原始内容存档于2008 10 07 Siddiqui Jain A Grand CL Bearss DJ Hurley LH Direct evidence for a G quadruplex in a promoter region and its targeting with a small molecule to repress c MYC transcription PNAS 2002 99 18 11593 8 2007 06 20 PMC 129314 nbsp PMID 12195017 doi 10 1073 pnas 182256799 原始内容存档于2007 10 01 Rawal P Kummarasetti VB Ravindran J Kumar N Halder K Sharma R Mukerji M Das SK Chowdhury S Genome wide prediction of G4 DNA as regulatory motifs Role in Escherichia coli global regulation Genome Res 2006 16 5 644 55 2007 06 20 PMC 1457047 nbsp PMID 16651665 doi 10 1101 gr 4508806 原始内容存档于2007 09 12 Xu Hou Wei Guo Fan Xia Fu Qiang Nie Hua Dong Ye Tian Liping Wen Lin Wang Liuxuan Cao Yang Yang Jianming Xue Yanlin Song Yugang Wang Dongsheng Liu and Lei Jiang A biomimetic potassium responsive nanochannel G quadruplex DNA conformational switching in a synthetic nanopore J Am Chem Soc 2009 131 22 7800 7805 2015 06 19 PMID 19435350 doi 10 1021 ja901574c 原始内容存档于2022 03 15 Neidle amp Balasubramanian 编 Quadruplex Nucleic Acids 2006 2007 06 20 ISBN 0 85404 374 8 原始内容存档于2007 09 30 外部連結 编辑Nanopore and Aptamer Biosensor group 页面存档备份 存于互联网档案馆 NAB group 四聯體網站 编辑 COST MP0802 Quadruplex Network the European network of G quadruplex community From first principles to applications Quadruplex org a website to serve the quadruplex community G Quadruplex World 页面存档备份 存于互联网档案馆 a website to discuss publications and other information of interest to those working in the field of G quadruplexes Quadbase downloadable data on predicted G quadruplexes Greglist a database listing potential G quadruplex regulated genes Database on Quadruplex information QuadBase from IGIB GRSDB 页面存档备份 存于互联网档案馆 a database of G quadruplexes near RNA processing sites GRS UTRdb a database of G quadruplexes in the UTRs G quadruplex Resource Site 页面存档备份 存于互联网档案馆 non B Motif Search Tool at non B DB a web server to predict G quadruplex forming motifs and other non B DNA forming motifs from users DNA sequences 預測G 四聯體的工具 编辑 Quadparser Downloadable program for finding putative quadruplex forming sequences 页面存档备份 存于互联网档案馆 from Balasubramanian s group QGRS Mapper a web based application for predicting G quadruplexes in nucleotide sequences and NCBI genes 页面存档备份 存于互联网档案馆 from Bagga s group Quadfinder Tool for Prediction and Analysis of G Quadruplex Motifs in DNA RNA Sequences from Maiti s group IGIB Delhi India 永久失效連結 取自 https zh wikipedia org w index php title G 四聯體 amp oldid 73103930, 维基百科，wiki，书籍，书籍，图书馆，
