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维基百科

ENCODE

DNA元件百科全书(英語:Encyclopedia of DNA Elements,简称为ENCODE项目)是一个由美国国家人类基因组研究所(NHGRI)在2003年9月发起的一项公共联合研究项目[2],旨在找出人类基因组中所有功能组件[1][3][4][5]

ENCODE
内容
相關信息
研究中心斯坦福大学
实验室
  • 聖塔克魯茲加利福尼亞大學(2003-2012)
  • 斯坦福大学(2007年至今)
創始人Brian J Raney[1]
发布日期2010年
访问入口
网站encodeproject.org
工具
其他

这是既完成人类基因组计划后国家人类基因组研究所开始的最重要的项目之一。

所有在该项目中产生的数据都会被迅速的在公共数据库中公开。

ENCOD项目

ENCODE分三个阶段实施:试验阶段,技术发展阶段,和生产阶段。

ENCODE一期项目:试验项目

试验项目测试和比较现有方法进行严格分析一个所定义的人类基因组序列的一部分。

ENCODE二期项目:生产阶段项目

 
ENCODE数据的图像,在UCSC Genome Browser英语UCSC Genome Browser。 This shows several tracks containing information on gene regulation. The gene on the left (ATP2B4) is transcribed in a wide variety of cells. The gene on the right is only transcribed in a few types of cells, including embryonic stem cells.

2007年9月,国家人类基因组研究所(NHGRI)开始了ENCODE项目生产阶段的拨款。在这个阶段,目标是分析整个基因组,并进行“额外中试规模研究”[6]

作为试点项目,生产工作被组织作为一个开放的联盟。 2007年10月,国家人类基因组研究所(NHGRI)在四年期间获拨款总额超过$8000万美元[7]。生产阶段还包括一个数据协调中心,数据分析中心,和技术开发工作[8]。当时该项目发展成为一个真正的全球性企业,涉及来自世界各地的32个实验室的440名科学家。

生产阶段结果

2012年9月5日,该项目的初步结果被整理为30篇论文并同时发表于多个刊物,包括6篇论文在《自然》、6篇论文在《基因组生物学》及18篇论文在《基因组研究》上[9][10]

最引人注目的发现是,人类DNA有生物活性的分数大于以前估计中即使是最乐观的估计还要高得多。这些发表的论文显示人类基因组内的非编码DNA至少80%是有生物活性的,而非像之前认为的仅仅是“垃圾”。这个结果非常重要,因为人类基因组中98%的DNA是非编码的,意味着它们并不直接编码任何蛋白质序列。

参见

参考文献

  1. ^ 1.0 1.1 Raney BJ, Cline MS, Rosenbloom KR, Dreszer TR, Learned K, Barber GP, Meyer LR, Sloan CA, Malladi VS, Roskin KM, Suh BB, Hinrichs AS, Clawson H, Zweig AS, Kirkup V, Fujita PA, Rhead B, Smith KE, Pohl A, Kuhn RM, Karolchik D, Haussler D, Kent, WJ. ENCODE whole-genome data in the UCSC genome browser (2011 update). Nucleic Acids Res. January 2011, 39 (Database issue): D871–5. PMC 3013645 . PMID 21037257. doi:10.1093/nar/gkq1017. 
  2. ^ Maher B. ENCODE: The human encyclopaedia. Nature. 2012, 489 (7414): 46–48. doi:10.1038/489046a. 
  3. ^ The ENCODE Project Consortium. A User's Guide to the Encyclopedia of DNA Elements (ENCODE). PLOS Biology. 2011-04-19, 9 (4): e1001046 [2018-04-02]. ISSN 1545-7885. doi:10.1371/journal.pbio.1001046. (原始内容于2018-03-28) (英语). 
  4. ^ ENCODE Project Consortium, Ewan Birney, John A. Stamatoyannopoulos, Anindya Dutta, Roderic Guigó, Thomas R. Gingeras, Elliott H. Margulies, Zhiping Weng, Michael Snyder, Emmanouil T. Dermitzakis, Robert E. Thurman, Michael S. Kuehn, Christopher M. Taylor, Shane Neph, Christoph M. Koch, Saurabh Asthana, Ankit Malhotra, Ivan Adzhubei, Jason A. Greenbaum, Robert M. Andrews, Paul Flicek, Patrick J. Boyle, Hua Cao, Nigel P. Carter, Gayle K. Clelland, Sean Davis, Nathan Day, Pawandeep Dhami, Shane C. Dillon, Michael O. Dorschner, Heike Fiegler, Paul G. Giresi, Jeff Goldy, Michael Hawrylycz, Andrew Haydock, Richard Humbert, Keith D. James, Brett E. Johnson, Ericka M. Johnson, Tristan T. Frum, Elizabeth R. Rosenzweig, Neerja Karnani, Kirsten Lee, Gregory C. Lefebvre, Patrick A. Navas, Fidencio Neri, Stephen C. J. Parker, Peter J. Sabo, Richard Sandstrom, Anthony Shafer, David Vetrie, Molly Weaver, Sarah Wilcox, Man Yu, Francis S. Collins, Job Dekker, Jason D. Lieb, Thomas D. Tullius, Gregory E. Crawford, Shamil Sunyaev, William S. Noble, Ian Dunham, France Denoeud, Alexandre Reymond, Philipp Kapranov, Joel Rozowsky, Deyou Zheng, Robert Castelo, Adam Frankish, Jennifer Harrow, Srinka Ghosh, Albin Sandelin, Ivo L. Hofacker, Robert Baertsch, Damian Keefe, Sujit Dike, Jill Cheng, Heather A. Hirsch, Edward A. Sekinger, Julien Lagarde, Josep F. Abril, Atif Shahab, Christoph Flamm, Claudia Fried, Jörg Hackermüller, Jana Hertel, Manja Lindemeyer, Kristin Missal, Andrea Tanzer, Stefan Washietl, Jan Korbel, Olof Emanuelsson, Jakob S. Pedersen, Nancy Holroyd, Ruth Taylor, David Swarbreck, Nicholas Matthews, Mark C. Dickson, Daryl J. Thomas, Matthew T. Weirauch, James Gilbert, Jorg Drenkow, Ian Bell, XiaoDong Zhao, K. G. Srinivasan, Wing-Kin Sung, Hong Sain Ooi, Kuo Ping Chiu, Sylvain Foissac, Tyler Alioto, Michael Brent, Lior Pachter, Michael L. Tress, Alfonso Valencia, Siew Woh Choo, Chiou Yu Choo, Catherine Ucla, Caroline Manzano, Carine Wyss, Evelyn Cheung, Taane G. Clark, James B. Brown, Madhavan Ganesh, Sandeep Patel, Hari Tammana, Jacqueline Chrast, Charlotte N. Henrichsen, Chikatoshi Kai, Jun Kawai, Ugrappa Nagalakshmi, Jiaqian Wu, Zheng Lian, Jin Lian, Peter Newburger, Xueqing Zhang, Peter Bickel, John S. Mattick, Piero Carninci, Yoshihide Hayashizaki, Sherman Weissman, Tim Hubbard, Richard M. Myers, Jane Rogers, Peter F. Stadler, Todd M. Lowe, Chia-Lin Wei, Yijun Ruan, Kevin Struhl, Mark Gerstein, Stylianos E. Antonarakis, Yutao Fu, Eric D. Green, Ulaş Karaöz, Adam Siepel, James Taylor, Laura A. Liefer, Kris A. Wetterstrand, Peter J. Good, Elise A. Feingold, Mark S. Guyer, Gregory M. Cooper, George Asimenos, Colin N. Dewey, Minmei Hou, Sergey Nikolaev, Juan I. Montoya-Burgos, Ari Löytynoja, Simon Whelan, Fabio Pardi, Tim Massingham, Haiyan Huang, Nancy R. Zhang, Ian Holmes, James C. Mullikin, Abel Ureta-Vidal, Benedict Paten, Michael Seringhaus, Deanna Church, Kate Rosenbloom, W. James Kent, Eric A. Stone, NISC Comparative Sequencing Program, Baylor College of Medicine Human Genome Sequencing Center, Washington University Genome Sequencing Center, Broad Institute, Children's Hospital Oakland Research Institute, Serafim Batzoglou, Nick Goldman, Ross C. Hardison, David Haussler, Webb Miller, Arend Sidow, Nathan D. Trinklein, Zhengdong D. Zhang, Leah Barrera, Rhona Stuart, David C. King, Adam Ameur, Stefan Enroth, Mark C. Bieda, Jonghwan Kim, Akshay A. Bhinge, Nan Jiang, Jun Liu, Fei Yao, Vinsensius B. Vega, Charlie W. H. Lee, Patrick Ng, Atif Shahab, Annie Yang, Zarmik Moqtaderi, Zhou Zhu, Xiaoqin Xu, Sharon Squazzo, Matthew J. Oberley, David Inman, Michael A. Singer, Todd A. Richmond, Kyle J. Munn, Alvaro Rada-Iglesias, Ola Wallerman, Jan Komorowski, Joanna C. Fowler, Phillippe Couttet, Alexander W. Bruce, Oliver M. Dovey, Peter D. Ellis, Cordelia F. Langford, David A. Nix, Ghia Euskirchen, Stephen Hartman, Alexander E. Urban, Peter Kraus, Sara Van Calcar, Nate Heintzman, Tae Hoon Kim, Kun Wang, Chunxu Qu, Gary Hon, Rosa Luna, Christopher K. Glass, M. Geoff Rosenfeld, Shelley Force Aldred, Sara J. Cooper, Anason Halees, Jane M. Lin, Hennady P. Shulha, Xiaoling Zhang, Mousheng Xu, Jaafar N. S. Haidar, Yong Yu, Yijun Ruan, Vishwanath R. Iyer, Roland D. Green, Claes Wadelius, Peggy J. Farnham, Bing Ren, Rachel A. Harte, Angie S. Hinrichs, Heather Trumbower, Hiram Clawson, Jennifer Hillman-Jackson, Ann S. Zweig, Kayla Smith, Archana Thakkapallayil, Galt Barber, Robert M. Kuhn, Donna Karolchik, Lluis Armengol, Christine P. Bird, Paul I. W. de Bakker, Andrew D. Kern, Nuria Lopez-Bigas, Joel D. Martin, Barbara E. Stranger, Abigail Woodroffe, Eugene Davydov, Antigone Dimas, Eduardo Eyras, Ingileif B. Hallgrímsdóttir, Julian Huppert, Michael C. Zody, Gonçalo R. Abecasis, Xavier Estivill, Gerard G. Bouffard, Xiaobin Guan, Nancy F. Hansen, Jacquelyn R. Idol, Valerie V. B. Maduro, Baishali Maskeri, Jennifer C. McDowell, Morgan Park, Pamela J. Thomas, Alice C. Young, Robert W. Blakesley, Donna M. Muzny, Erica Sodergren, David A. Wheeler, Kim C. Worley, Huaiyang Jiang, George M. Weinstock, Richard A. Gibbs, Tina Graves, Robert Fulton, Elaine R. Mardis, Richard K. Wilson, Michele Clamp, James Cuff, Sante Gnerre, David B. Jaffe, Jean L. Chang, Kerstin Lindblad-Toh, Eric S. Lander, Maxim Koriabine, Mikhail Nefedov, Kazutoyo Osoegawa, Yuko Yoshinaga, Baoli Zhu, Pieter J. de Jong. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007-06-14, 447 (7146): 799–816 [2019-02-12]. ISSN 1476-4687. PMC 2212820 . PMID 17571346. doi:10.1038/nature05874. (原始内容于2019-06-19). 
  5. ^ Roderic Guigó, Paul Flicek, Josep F. Abril, Alexandre Reymond, Julien Lagarde, France Denoeud, Stylianos Antonarakis, Michael Ashburner, Vladimir B. Bajic, Ewan Birney, Robert Castelo, Eduardo Eyras, Catherine Ucla, Thomas R. Gingeras, Jennifer Harrow, Tim Hubbard, Suzanna E. Lewis, Martin G. Reese. EGASP: the human ENCODE Genome Annotation Assessment Project. Genome Biology. 2006,. 7 Suppl 1: S2.1–31 [2019-02-12]. ISSN 1474-760X. doi:10.1186/gb-2006-7-s1-s2. (原始内容于2016-04-01). 
  6. ^ Genome.gov | ENCODE and modENCODE Projects. The ENCODE Project: ENCyclopedia Of DNA Elements. United States National Human Genome Research Institute. 2011-08-01 [2011-08-05]. (原始内容于2011-08-07). 
  7. ^ National Human Genome Research Institute - Organization. The NIH Almanac. United States National Institutes of Health. [2011-08-05]. (原始内容于2015-10-04). 
  8. ^ Genome.gov | ENCODE Participants and Projects. The ENCODE Project: ENCyclopedia Of DNA Elements. United States National Human Genome Research Institute. 2011-08-01 [2011-08-05]. (原始内容于2011-08-07). 
  9. ^ ENCODE project at UCSC. ENCODE Consortium. [2012-09-05]. (原始内容于2012-09-10). 
  10. ^ Walsh, Fergus. Detailed map of genome function. BBC News. 2012-09-05 [2012-09-06]. (原始内容存档于2012-09-06). 

外部链接

encode, dna元件百科全书, 英語, encyclopedia, elements, 简称为项目, 是一个由美国国家人类基因组研究所, nhgri, 在2003年9月发起的一项公共联合研究项目, 旨在找出人类基因组中所有功能组件, 内容相關信息研究中心斯坦福大学实验室聖塔克魯茲加利福尼亞大學, 2003, 2012, 斯坦福大学, 2007年至今, 創始人brian, raney, 发布日期2010年访问入口网站encodeproject, org工具其他这是既完成人类基因组计划后国家人类基因组研究所开始的. DNA元件百科全书 英語 Encyclopedia of DNA Elements 简称为ENCODE项目 是一个由美国国家人类基因组研究所 NHGRI 在2003年9月发起的一项公共联合研究项目 2 旨在找出人类基因组中所有功能组件 1 3 4 5 ENCODE内容相關信息研究中心斯坦福大学实验室聖塔克魯茲加利福尼亞大學 2003 2012 斯坦福大学 2007年至今 創始人Brian J Raney 1 发布日期2010年访问入口网站encodeproject wbr org工具其他这是既完成人类基因组计划后国家人类基因组研究所开始的最重要的项目之一 所有在该项目中产生的数据都会被迅速的在公共数据库中公开 目录 1 ENCOD项目 1 1 ENCODE一期项目 试验项目 1 2 ENCODE二期项目 生产阶段项目 1 2 1 生产阶段结果 2 参见 3 参考文献 4 外部链接ENCOD项目 编辑ENCODE分三个阶段实施 试验阶段 技术发展阶段 和生产阶段 ENCODE一期项目 试验项目 编辑 试验项目测试和比较现有方法进行严格分析一个所定义的人类基因组序列的一部分 ENCODE二期项目 生产阶段项目 编辑 ENCODE数据的图像 在UCSC Genome Browser 英语 UCSC Genome Browser This shows several tracks containing information on gene regulation The gene on the left ATP2B4 is transcribed in a wide variety of cells The gene on the right is only transcribed in a few types of cells including embryonic stem cells 2007年9月 国家人类基因组研究所 NHGRI 开始了ENCODE项目生产阶段的拨款 在这个阶段 目标是分析整个基因组 并进行 额外中试规模研究 6 作为试点项目 生产工作被组织作为一个开放的联盟 2007年10月 国家人类基因组研究所 NHGRI 在四年期间获拨款总额超过 8000万美元 7 生产阶段还包括一个数据协调中心 数据分析中心 和技术开发工作 8 当时该项目发展成为一个真正的全球性企业 涉及来自世界各地的32个实验室的440名科学家 生产阶段结果 编辑 2012年9月5日 该项目的初步结果被整理为30篇论文并同时发表于多个刊物 包括6篇论文在 自然 6篇论文在 基因组生物学 及18篇论文在 基因组研究 上 9 10 最引人注目的发现是 人类DNA有生物活性的分数大于以前估计中即使是最乐观的估计还要高得多 这些发表的论文显示人类基因组内的非编码DNA至少80 是有生物活性的 而非像之前认为的仅仅是 垃圾 这个结果非常重要 因为人类基因组中98 的DNA是非编码的 意味着它们并不直接编码任何蛋白质序列 参见 编辑SIMAP 人类基因组计划 千人基因组计划 国际人类基因组单体型图计划 简称HapMap计划 参考文献 编辑 1 0 1 1 Raney BJ Cline MS Rosenbloom KR Dreszer TR Learned K Barber GP Meyer LR Sloan CA Malladi VS Roskin KM Suh BB Hinrichs AS Clawson H Zweig AS Kirkup V Fujita PA Rhead B Smith KE Pohl A Kuhn RM Karolchik D Haussler D Kent WJ ENCODE whole genome data in the UCSC genome browser 2011 update Nucleic Acids Res January 2011 39 Database issue D871 5 PMC 3013645 PMID 21037257 doi 10 1093 nar gkq1017 Maher B ENCODE The human encyclopaedia Nature 2012 489 7414 46 48 doi 10 1038 489046a The ENCODE Project Consortium A User s Guide to the Encyclopedia of DNA Elements ENCODE PLOS Biology 2011 04 19 9 4 e1001046 2018 04 02 ISSN 1545 7885 doi 10 1371 journal pbio 1001046 原始内容存档于2018 03 28 英语 ENCODE Project Consortium Ewan Birney John A Stamatoyannopoulos Anindya Dutta Roderic Guigo Thomas R Gingeras Elliott H Margulies Zhiping Weng Michael Snyder Emmanouil T Dermitzakis Robert E Thurman Michael S Kuehn Christopher M Taylor Shane Neph Christoph M Koch Saurabh Asthana Ankit Malhotra Ivan Adzhubei Jason A Greenbaum Robert M Andrews Paul Flicek Patrick J Boyle Hua Cao Nigel P Carter Gayle K Clelland Sean Davis Nathan Day Pawandeep Dhami Shane C Dillon Michael O Dorschner Heike Fiegler Paul G Giresi Jeff Goldy Michael Hawrylycz Andrew Haydock Richard Humbert Keith D James Brett E Johnson Ericka M Johnson Tristan T Frum Elizabeth R Rosenzweig Neerja Karnani Kirsten Lee Gregory C Lefebvre Patrick A Navas Fidencio Neri Stephen C J Parker Peter J Sabo Richard Sandstrom Anthony Shafer David Vetrie Molly Weaver Sarah Wilcox Man Yu Francis S Collins Job Dekker Jason D Lieb Thomas D Tullius Gregory E Crawford Shamil Sunyaev William S Noble Ian Dunham France Denoeud Alexandre Reymond Philipp Kapranov Joel Rozowsky Deyou Zheng Robert Castelo Adam Frankish Jennifer Harrow Srinka Ghosh Albin Sandelin Ivo L Hofacker Robert Baertsch Damian Keefe Sujit Dike Jill Cheng Heather A Hirsch Edward A Sekinger Julien Lagarde Josep F Abril Atif Shahab Christoph Flamm Claudia Fried Jorg Hackermuller Jana Hertel Manja Lindemeyer Kristin Missal Andrea Tanzer Stefan Washietl Jan Korbel Olof Emanuelsson Jakob S Pedersen Nancy Holroyd Ruth Taylor David Swarbreck Nicholas Matthews Mark C Dickson Daryl J Thomas Matthew T Weirauch James Gilbert Jorg Drenkow Ian Bell XiaoDong Zhao K G Srinivasan Wing Kin Sung Hong Sain Ooi Kuo Ping Chiu Sylvain Foissac Tyler Alioto Michael Brent Lior Pachter Michael L Tress Alfonso Valencia Siew Woh Choo Chiou Yu Choo Catherine Ucla Caroline Manzano Carine Wyss Evelyn Cheung Taane G Clark James B Brown Madhavan Ganesh Sandeep Patel Hari Tammana Jacqueline Chrast Charlotte N Henrichsen Chikatoshi Kai Jun Kawai Ugrappa Nagalakshmi Jiaqian Wu Zheng Lian Jin Lian Peter Newburger Xueqing Zhang Peter Bickel John S Mattick Piero Carninci Yoshihide Hayashizaki Sherman Weissman Tim Hubbard Richard M Myers Jane Rogers Peter F Stadler Todd M Lowe Chia Lin Wei Yijun Ruan Kevin Struhl Mark Gerstein Stylianos E Antonarakis Yutao Fu Eric D Green Ulas Karaoz Adam Siepel James Taylor Laura A Liefer Kris A Wetterstrand Peter J Good Elise A Feingold Mark S Guyer Gregory M Cooper George Asimenos Colin N Dewey Minmei Hou Sergey Nikolaev Juan I Montoya Burgos Ari Loytynoja Simon Whelan Fabio Pardi Tim Massingham Haiyan Huang Nancy R Zhang Ian Holmes James C Mullikin Abel Ureta Vidal Benedict Paten Michael Seringhaus Deanna Church Kate Rosenbloom W James Kent Eric A Stone NISC Comparative Sequencing Program Baylor College of Medicine Human Genome Sequencing Center Washington University Genome Sequencing Center Broad Institute Children s Hospital Oakland Research Institute Serafim Batzoglou Nick Goldman Ross C Hardison David Haussler Webb Miller Arend Sidow Nathan D Trinklein Zhengdong D Zhang Leah Barrera Rhona Stuart David C King Adam Ameur Stefan Enroth Mark C Bieda Jonghwan Kim Akshay A Bhinge Nan Jiang Jun Liu Fei Yao Vinsensius B Vega Charlie W H Lee Patrick Ng Atif Shahab Annie Yang Zarmik Moqtaderi Zhou Zhu Xiaoqin Xu Sharon Squazzo Matthew J Oberley David Inman Michael A Singer Todd A Richmond Kyle J Munn Alvaro Rada Iglesias Ola Wallerman Jan Komorowski Joanna C Fowler Phillippe Couttet Alexander W Bruce Oliver M Dovey Peter D Ellis Cordelia F Langford David A Nix Ghia Euskirchen Stephen Hartman Alexander E Urban Peter Kraus Sara Van Calcar Nate Heintzman Tae Hoon Kim Kun Wang Chunxu Qu Gary Hon Rosa Luna Christopher K Glass M Geoff Rosenfeld Shelley Force Aldred Sara J Cooper Anason Halees Jane M Lin Hennady P Shulha Xiaoling Zhang Mousheng Xu Jaafar N S Haidar Yong Yu Yijun Ruan Vishwanath R Iyer Roland D Green Claes Wadelius Peggy J Farnham Bing Ren Rachel A Harte Angie S Hinrichs Heather Trumbower Hiram Clawson Jennifer Hillman Jackson Ann S Zweig Kayla Smith Archana Thakkapallayil Galt Barber Robert M Kuhn Donna Karolchik Lluis Armengol Christine P Bird Paul I W de Bakker Andrew D Kern Nuria Lopez Bigas Joel D Martin Barbara E Stranger Abigail Woodroffe Eugene Davydov Antigone Dimas Eduardo Eyras Ingileif B Hallgrimsdottir Julian Huppert Michael C Zody Goncalo R Abecasis Xavier Estivill Gerard G Bouffard Xiaobin Guan Nancy F Hansen Jacquelyn R Idol Valerie V B Maduro Baishali Maskeri Jennifer C McDowell Morgan Park Pamela J Thomas Alice C Young Robert W Blakesley Donna M Muzny Erica Sodergren David A Wheeler Kim C Worley Huaiyang Jiang George M Weinstock Richard A Gibbs Tina Graves Robert Fulton Elaine R Mardis Richard K Wilson Michele Clamp James Cuff Sante Gnerre David B Jaffe Jean L Chang Kerstin Lindblad Toh Eric S Lander Maxim Koriabine Mikhail Nefedov Kazutoyo Osoegawa Yuko Yoshinaga Baoli Zhu Pieter J de Jong Identification and analysis of functional elements in 1 of the human genome by the ENCODE pilot project Nature 2007 06 14 447 7146 799 816 2019 02 12 ISSN 1476 4687 PMC 2212820 PMID 17571346 doi 10 1038 nature05874 原始内容存档于2019 06 19 引文格式1维护 PMC格式 link Roderic Guigo Paul Flicek Josep F Abril Alexandre Reymond Julien Lagarde France Denoeud Stylianos Antonarakis Michael Ashburner Vladimir B Bajic Ewan Birney Robert Castelo Eduardo Eyras Catherine Ucla Thomas R Gingeras Jennifer Harrow Tim Hubbard Suzanna E Lewis Martin G Reese EGASP the human ENCODE Genome Annotation Assessment Project Genome Biology 2006 7 Suppl 1 S2 1 31 2019 02 12 ISSN 1474 760X doi 10 1186 gb 2006 7 s1 s2 原始内容存档于2016 04 01 Genome gov ENCODE and modENCODE Projects The ENCODE Project ENCyclopedia Of DNA Elements United States National Human Genome Research Institute 2011 08 01 2011 08 05 原始内容存档于2011 08 07 National Human Genome Research Institute Organization The NIH Almanac United States National Institutes of Health 2011 08 05 原始内容存档于2015 10 04 Genome gov ENCODE Participants and Projects The ENCODE Project ENCyclopedia Of DNA Elements United States National Human Genome Research Institute 2011 08 01 2011 08 05 原始内容存档于2011 08 07 ENCODE project at UCSC ENCODE Consortium 2012 09 05 原始内容存档于2012 09 10 Walsh Fergus Detailed map of genome function BBC News 2012 09 05 2012 09 06 原始内容存档于2012 09 06 外部链接 编辑官方网站 ENCODE Project at UCSC ENCODE project 页面存档备份 存于互联网档案馆 at the National Human Genome Research Institute ENCODE GENCODE project 页面存档备份 存于互联网档案馆 at the Wellcome Trust Sanger Institute ENCODE sponsored introductory tutorial FactorBook 页面存档备份 存于互联网档案馆 ENCODE threads Explorer 页面存档备份 存于互联网档案馆 at the Nature journal 取自 https zh wikipedia org w index php title ENCODE amp oldid 69448009, 维基百科,wiki,书籍,书籍,图书馆,

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