4-羟基雌二醇

4-羟基雌二醇（英語：4-Hydroxyestradiol，缩写4-OHE2，或称为雌甾-1,3,5(10)-三烯-3,4,17β-三醇，estra-1,3,5(10)-triene-3,4,17β-triol）是一种内源性的天然儿茶酚雌激素和雌酮与雌二醇的次要代謝產物^[2]，带有一定的雌激素活性^[2][3]。

4-羟基雌二醇
IUPAC名 (8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol
别名	4-OHE2; Estra-1,3,5(10)-triene-3,4,17β-triol; 3,4,17β-Trihydroxyestra-1,3,5(10)-triene
识别
CAS号	5976-61-4
PubChem	5282360
ChemSpider	4445523
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4O)O
ChEBI	62845
KEGG	C14209
性质
化学式	C18H24O3
摩尔质量	288.38 g·mol^−1
熔点	252－253 °C（525－526 K）^[1]
若非注明，所有数据均出自一般条件（25 ℃，100 kPa）下。

参考资料

1. Hecker, Erich; Walk, Elisabeth. The chemistry of the p-quinols. III. o-Quinone diacetates and amino analogs of natural estrogens. Chemische Berichte, 1960. 93: 2928-2937. ISSN: 0009-2940.
2. Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 224, 232, 244–245, 249. ISBN 978-3-642-58616-3. 
3. Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. J. Soc. Gynecol. Investig. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6. 

外部链接

• Metabocard for 4-Hydroxyestradiol - Human Metabolome Database （页面存档备份，存于互联网档案馆）