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十月 08, 2023
21號染色體, 人類的是23對染色體的其中之一, 正常狀況下每個細胞擁有兩條, 此染色體是所有人類染色體中最小的一個, 含有大約4700萬個鹼基對, 佔細胞內所有dna的1, 物種, homo, sapiens基因數量, 400的定序是在2000年宣布完成, 是人類基因組計畫中第二條定序完成的人類染色體, 此染色體內大約含有300到400個基因, 依預測方式而有所不同, 相關疾病, 编辑阿茲海默症第一型, 肌肉萎縮性側索硬化症, 漸凍人症, 第一型, 唐氏症候群, holocarboxylase, syntheta. 人類的21號染色體是23對染色體的其中之一 正常狀況下每個細胞擁有兩條 此染色體是所有人類染色體中最小的一個 含有大約4700萬個鹼基對 佔細胞內所有DNA的1 5 21號染色體物種 Homo sapiens基因數量 200 40021號染色體的定序是在2000年宣布完成 是人類基因組計畫中第二條定序完成的人類染色體 此染色體內大約含有300到400個基因 依預測方式而有所不同 相關疾病 编辑阿茲海默症第一型 肌肉萎縮性側索硬化症 漸凍人症 第一型 唐氏症候群 Holocarboxylase synthetase deficiency Homocystinuria Jervell and Lange Nielsen syndrome Leukocyte adhesion deficiency Nonsyndromic deafness Nonsyndromic deafness autosomal recessive Romano Ward syndrome参考文献 编辑Antonarakis SE Lyle R Dermitzakis ET Reymond A Deutsch S Chromosome 21 and down syndrome from genomics to pathophysiology Nat Rev Genet 2004 5 10 725 38 PMID 15510164 Antonarakis SE Lyle R Deutsch S Reymond A Chromosome 21 a small land of fascinating disorders with unknown pathophysiology Int J Dev Biol 2002 46 1 89 96 PMID 11902692 Antonarakis SE Chromosome 21 from sequence to applications Curr Opin Genet Dev 2001 11 3 241 6 PMID 11377958 Gardiner K Davisson M The sequence of human chromosome 21 and implications for research into Down syndrome Genome Biol 2000 1 2 REVIEWS0002 PMID 11178230 Gilbert F Disease genes and chromosomes disease maps of the human genome Chromosome 21 Genet Test 1997 1 4 301 6 PMID 10464663 Hattori M Fujiyama A Taylor TD Watanabe H Yada T Park HS Toyoda A Ishii K Totoki Y Choi DK Groner Y Soeda E Ohki M Takagi T Sakaki Y Taudien S Blechschmidt K Polley A Menzel U Delabar J Kumpf K Lehmann R Patterson D Reichwald K Rump A Schillhabel M Schudy A Zimmermann W Rosenthal A Kudoh J Schibuya K Kawasaki K Asakawa S Shintani A Sasaki T Nagamine K Mitsuyama S Antonarakis SE Minoshima S Shimizu N Nordsiek G Hornischer K Brant P Scharfe M Schon O Desario A Reichelt J Kauer G Blocker H Ramser J Beck A Klages S Hennig S Riesselmann L Dagand E Haaf T Wehrmeyer S Borzym K Gardiner K Nizetic D Francis F Lehrach H Reinhardt R Yaspo ML The DNA sequence of human chromosome 21 Nature 2000 405 6784 311 9 PMID 10830953 Sawinska M Ladon D Mechanism detection and clinical significance of the reciprocal translocation t 12 21 p12 q22 in the children suffering from acute lymphoblastic leukaemia Leuk Res 2004 28 1 35 42 PMID 14630078 Sleegers K Brouwers N Gijselinck I Theuns J Goossens D Wauters J Del Favero J Cruts M van Duijn CM Van Broeckhoven C APP duplication is sufficient to cause early onset Alzheimer s dementia with cerebral amyloid angiopathy Brain 2006 PMID 16921174 Rovelet Lecrux A Hannequin D Raux G Le Meur N Laquerriere A Vital A Dumanchin C Feuillette S Brice A Vercelletto M Dubas F Frebourg T Campion D APP locus duplication causes autosomal dominant early onset Alzheimer disease with cerebral amyloid angiopathy Nature Genetics 2005 PMID 16369530 取自 https zh wikipedia org w index php title 21號染色體 amp oldid 71711830, 维基百科，wiki，书籍，书籍，图书馆，
