CD4+ Foxp3+ CD25(high) regulatory T cells have been called "naturally occurring" regulatory T cells[4] to distinguish them from "suppressor" T cell populations that are generated in vitro. Additional regulatory T cell populations include Tr1, Th3, CD8+CD28-, and Qa-1 restricted T cells. The contribution of these populations to self-tolerance and immune homeostasis is less well defined. Foxp3 can be used as a good marker for mouse CD4+CD25+ T cells, although recent studies have also shown evidence for Foxp3 expression in CD4+CD25- T cells. In humans, Foxp3 is also expressed by recently activated conventional T-cells and thus does not specifically identify human Tregs.[5]
^Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. February 2003, 299 (5609): 1057–61. Bibcode:2003Sci...299.1057H. PMID 12522256. doi:10.1126/science.1079490.
^Singh B, Schwartz JA, Sandrock C, Bellemore SM, Nikoopour E. Modulation of autoimmune diseases by interleukin (IL)-17 producing regulatory T helper (Th17) cells. The Indian Journal of Medical Research. November 2013, 138 (5): 591–4. PMC 3928692. PMID 24434314.
^Shevach EM. Regulatory T cells in autoimmmunity*. Annual Review of Immunology. 2000, 18: 423–49. PMID 10837065. doi:10.1146/annurev.immunol.18.1.423.
^Schmetterer, Klaus G.; Neunkirchner, Alina; Pickl, Winfried F. Naturally occurring regulatory T cells: markers, mechanisms, and manipulation. The FASEB Journal. June 2012, 26 (6): 2253–2276. ISSN 0892-6638. PMID 22362896. doi:10.1096/fj.11-193672.
^Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annual Review of Immunology. 2004, 22: 531–62. PMID 15032588. doi:10.1146/annurev.immunol.21.120601.141122.
一月 30, 2023
调节t细胞, regulatory, cell, treg, 是一群具有负调节机体免疫反应的淋巴细胞, 通常起着维持自身耐受和避免免疫反应过度损伤机体的重要作用, 但也参与肿瘤细胞逃避机体免疫监视和慢性感染, 70年代曾命名为抑制t细胞, suppressor, cell, 因缺乏明确的表面标志, 研究长期处于尴尬和停顿的境地, 直到90年代研究出现转机并成为目前研究热点, 但现多称为, regulatory, cell, 調節性t細胞最重要的分子標記是一種轉錄因子foxp3, 在所有調節性t細胞中均可發現有多量表. 调节T细胞 regulatory T cell Treg 是一群具有负调节机体免疫反应的淋巴细胞 通常起着维持自身耐受和避免免疫反应过度损伤机体的重要作用 但也参与肿瘤细胞逃避机体免疫监视和慢性感染 70年代曾命名为抑制T细胞 suppressor T cell 因缺乏明确的表面标志 研究长期处于尴尬和停顿的境地 直到90年代研究出现转机并成为目前研究热点 但现多称为调节T细胞 regulatory T cell 調節性T細胞最重要的分子標記是一種轉錄因子Foxp3 在所有調節性T細胞中均可發現有多量表現 亚群 编辑调节T细胞是免疫系统的重要组成成分 可抑制其他免疫细胞的免疫反應 这是免疫系统之中重要的 自检 组分 可防止产生过激的免疫反應 调节T细胞有多种形式 但被了解的最透彻的是表达CD4 CD25及FOXP3调节T细胞 CD4 CD25 调节T细胞 调节T细胞与辅助T细胞不同 1 另一类调节T细胞亚群是Treg17细胞 2 调节T细胞参与到成功清除入侵生物后关闭免疫反應之中 同时也防止产生自身免疫反應 3 CD4 Foxp3 CD25 high regulatory T cells have been called naturally occurring regulatory T cells 4 to distinguish them from suppressor T cell populations that are generated in vitro Additional regulatory T cell populations include Tr1 Th3 CD8 CD28 and Qa 1 restricted T cells The contribution of these populations to self tolerance and immune homeostasis is less well defined Foxp3 can be used as a good marker for mouse CD4 CD25 T cells although recent studies have also shown evidence for Foxp3 expression in CD4 CD25 T cells In humans Foxp3 is also expressed by recently activated conventional T cells and thus does not specifically identify human Tregs 5 调节 抑制T细胞有很多种 可分為自然存在與誘導產生兩類 自然存在 CD4 CD25 T细胞 在维持机体对自身抗原的耐受中扮演重要角色 是目前研究最广泛深入的一种调节 抑制T细胞 誘導產生 TR1细胞 以分泌IL 10为特征 负调节免疫应答 TH3细胞 最早在口服免疫耐受性動物模型中發現 以分泌轉化生長因子 b TGF b 作為其功能性細胞激素 研究顯示可能與口服免疫耐受性 黏膜免疫機制有關 參見 编辑坂口志文参考资料 编辑 Hori S Nomura T Sakaguchi S Control of regulatory T cell development by the transcription factor Foxp3 Science February 2003 299 5609 1057 61 Bibcode 2003Sci 299 1057H PMID 12522256 doi 10 1126 science 1079490 Singh B Schwartz JA Sandrock C Bellemore SM Nikoopour E Modulation of autoimmune diseases by interleukin IL 17 producing regulatory T helper Th17 cells The Indian Journal of Medical Research November 2013 138 5 591 4 PMC 3928692 PMID 24434314 Shevach EM Regulatory T cells in autoimmmunity Annual Review of Immunology 2000 18 423 49 PMID 10837065 doi 10 1146 annurev immunol 18 1 423 Schmetterer Klaus G Neunkirchner Alina Pickl Winfried F Naturally occurring regulatory T cells markers mechanisms and manipulation The FASEB Journal June 2012 26 6 2253 2276 ISSN 0892 6638 PMID 22362896 doi 10 1096 fj 11 193672 Sakaguchi S Naturally arising CD4 regulatory t cells for immunologic self tolerance and negative control of immune responses Annual Review of Immunology 2004 22 531 62 PMID 15032588 doi 10 1146 annurev immunol 21 120601 141122 取自 https zh wikipedia org w index php title 调节T细胞 amp oldid 74243691, 维基百科，wiki，书籍，书籍，图书馆，
